Ion channels generate bioelectricity. Recent findings have documented the biophysical properties, the structure, assembly and regulation, and function and dysfunction of nonclassical nervous system ion channels. This book reviews nonclassical ion channel research, ranging from the basic biology, structure, regulations to their functions not only in normal physiology but also neurological disorders, using a variety of cutting-edge techniques and novel animal models.

Ion channels generate bioelectricity. Recent findings have documented the biophysical properties, the structure, assembly and regulation, and function and dysfunction of nonclassical nervous system ion channels. This book reviews nonclassical ion channel research, ranging from the basic biology, structure, regulations to their functions not only in normal physiology but also neurological disorders, using a variety of cutting-edge techniques and novel animal models.

This book constitutes the refereed post-conference proceedings of the 13th EAI International Conference on Broadband Communications, Networks, and Systems, Broadnets 2022, which took place in March 2023. Due to COVID-19 pandemic the conference was held virtually. The 9 full papers presented were carefully reviewed and selected from 23 submissions. The papers are thematically grouped as follows: Mobile Communication Networks; Mobile Software Security; and Algorithm, Model and Application. The scope of this conference is the 5G-enabled digital society.

This book proposes the concept of a multi-layer pavement system to fulfill the blast resistance requirement for pavement design. It also presents a damage pattern chart for multi-layer pavement design and rapid repair after blast load. Such a multi-layer system consists of three layers including asphalt concrete (AC) reinforced with Geogrid (GST) at the top, a high-strength concrete (HSC) layer in the middle, and engineered cementitious composites (ECC) at the bottom. A series of large-scale laboratory impact tests were carried out to prove the usefulness of this concept and show its advantages over other conventional pavement system. Furthermore, field blast tests were conducted to show the actual behavior of this multi-layer pavement system subjected to blast load under real-world conditions.

Although the particle swarm optimisation (PSO) algorithm requires relatively few parameters and is computationally simple and easy to implement, it is not a globally convergent algorithm. In Particle Swarm Optimisation: Classical and Quantum Perspectives, the authors introduce their concept of quantum-behaved particles inspired by quantum mechanics, which leads to the quantum-behaved particle swarm optimisation (QPSO) algorithm. This globally convergent algorithm has fewer parameters, a faster convergence rate, and stronger searchability for complex problems. The book presents the concepts of optimisation problems as well as random search methods for optimisation before discussing the principles of the PSO algorithm. Examples illustrate how the PSO algorithm solves optimisation problems. The authors also analyse the reasons behind the shortcomings of the PSO algorithm. Moving on to the QPSO algorithm, the authors give a thorough overview of the literature on QPSO, describe the fundamental model for the QPSO algorithm, and explore applications of the algorithm to solve typical optimisation problems. They also discuss some advanced theoretical topics, including the behaviour of individual particles, global convergence, computational complexity, convergence rate, and parameter selection. The text closes with coverage of several real-world applications, including inverse problems, optimal design of digital filters, economic dispatch problems, biological multiple sequence alignment, and image processing. MATLAB (R), Fortran, and C++ source codes for the main algorithms are provided on an accompanying downloadable resources. Helping you numerically solve optimisation problems, this book focuses on the fundamental principles and applications of PSO and QPSO algorithms. It not only explains how to use the algorithms, but also covers advanced topics that establish the groundwork for understanding.

This volume presents a collection of protocols that describe methodologies to study thermogenic fat biology from various angles. This book is divided into 2 parts. Part 1 focuses on establishing in vitro culture systems. The chapters in this section introduce techniques on how to isolate, culture, and differentiate primary fat cells from both laboratory mice and humans. This part also presents flow cytometry methods to isolate various subpopulations of precursors within the stromal vascular fraction of the adipose tissue, which contains both preadipocytes and immune cells. Part 2 introduces multiple means to genetically manipulate and evaluate brown and beige fat in vivo. The chapters in this section explore methods on bioenergetics analyses both in vitro and in vivo. They also cover how to evaluate thermogenic fat contents and activity in humans, how to culture these cells though interdisciplinary approaches, and how to use thermogenic fat cell lines to carry out drug screens. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and cutting-edge, Thermogenic Fat: Methods and Protocols is a valuable resource for both experts and novices who are interested in learning assays and investigating brown and beige fat functions.

This book proposes the concept of a multi-layer pavement system to fulfill the blast resistance requirement for pavement design. It also presents a damage pattern chart for multi-layer pavement design and rapid repair after blast load. Such a multi-layer system consists of three layers including asphalt concrete (AC) reinforced with Geogrid (GST) at the top, a high-strength concrete (HSC) layer in the middle, and engineered cementitious composites (ECC) at the bottom. A series of large-scale laboratory impact tests were carried out to prove the usefulness of this concept and show its advantages over other conventional pavement system. Furthermore, field blast tests were conducted to show the actual behavior of this multi-layer pavement system subjected to blast load under real-world conditions.

This volume presents a collection of protocols that describe methodologies to study thermogenic fat biology from various angles. This book is divided into 2 parts. Part 1 focuses on establishing in vitro culture systems. The chapters in this section introduce techniques on how to isolate, culture, and differentiate primary fat cells from both laboratory mice and humans. This part also presents flow cytometry methods to isolate various subpopulations of precursors within the stromal vascular fraction of the adipose tissue, which contains both preadipocytes and immune cells. Part 2 introduces multiple means to genetically manipulate and evaluate brown and beige fat in vivo. The chapters in this section explore methods on bioenergetics analyses both in vitro and in vivo. They also cover how to evaluate thermogenic fat contents and activity in humans, how to culture these cells though interdisciplinary approaches, and how to use thermogenic fat cell lines to carry out drug screens. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and cutting-edge, Thermogenic Fat: Methods and Protocols is a valuable resource for both experts and novices who are interested in learning assays and investigating brown and beige fat functions.

This book presents the latest research on the software crowdsourcing approach to develop large and complex software in a cloud-based platform. It develops the fundamental principles, management organization and processes, and a cloud-based infrastructure to support this new software development approach. The book examines a variety of issues in software crowdsourcing processes, including software quality, costs, diversity of solutions, and the competitive nature of crowdsourcing processes. Furthermore, the book outlines a research roadmap of this emerging field, including all the key technology and management issues for the foreseeable future. Crowdsourcing, as demonstrated by Wikipedia and Facebook for online web applications, has shown promising results for a variety of applications, including healthcare, business, gold mining exploration, education, and software development. Software crowdsourcing is emerging as a promising solution to designing, developing and maintaining software. Preliminary software crowdsourcing practices and platforms, including Apple's App Store and TopCoder, demonstrate the advantages of crowdsourcing in terms of software ecosystem expansion and product quality improvement.

The Beauty of Mathematics in Computer Science explains the mathematical fundamentals of information technology products and services we use every day, from Google Web Search to GPS Navigation, and from speech recognition to CDMA mobile services. The book was published in Chinese in 2011 and has sold more than 600,000 copies. Readers were surprised to find that many daily-used IT technologies were so tightly tied to mathematical principles. For example, the automatic classification of news articles uses the cosine law taught in high school. The book covers many topics related to computer applications and applied mathematics including: Natural language processing Speech recognition and machine translation Statistical language modeling Quantitive measurement of information Graph theory and web crawler Pagerank for web search Matrix operation and document classification Mathematical background of big data Neural networks and Google's deep learning Jun Wu was a staff research scientist in Google who invented Google's Chinese, Japanese, and Korean Web Search Algorithms and was responsible for many Google machine learning projects. He wrote official blogs introducing Google technologies behind its products in very simple languages for Chinese Internet users from 2006-2010. The blogs had more than 2 million followers. Wu received PhD in computer science from Johns Hopkins University and has been working on speech recognition and natural language processing for more than 20 years. He was one of the earliest engineers of Google, managed many products of the company, and was awarded 19 US patents during his 10-year tenure there. Wu became a full-time VC investor and co-founded Amino Capital in Palo Alto in 2014 and is the author of eight books.

Although the particle swarm optimisation (PSO) algorithm requires relatively few parameters and is computationally simple and easy to implement, it is not a globally convergent algorithm. In Particle Swarm Optimisation: Classical and Quantum Perspectives, the authors introduce their concept of quantum-behaved particles inspired by quantum mechanics, which leads to the quantum-behaved particle swarm optimisation (QPSO) algorithm. This globally convergent algorithm has fewer parameters, a faster convergence rate, and stronger searchability for complex problems. The book presents the concepts of optimisation problems as well as random search methods for optimisation before discussing the principles of the PSO algorithm. Examples illustrate how the PSO algorithm solves optimisation problems. The authors also analyse the reasons behind the shortcomings of the PSO algorithm. Moving on to the QPSO algorithm, the authors give a thorough overview of the literature on QPSO, describe the fundamental model for the QPSO algorithm, and explore applications of the algorithm to solve typical optimisation problems. They also discuss some advanced theoretical topics, including the behaviour of individual particles, global convergence, computational complexity, convergence rate, and parameter selection. The text closes with coverage of several real-world applications, including inverse problems, optimal design of digital filters, economic dispatch problems, biological multiple sequence alignment, and image processing. MATLAB (R), Fortran, and C++ source codes for the main algorithms are provided on an accompanying downloadable resources. Helping you numerically solve optimisation problems, this book focuses on the fundamental principles and applications of PSO and QPSO algorithms. It not only explains how to use the algorithms, but also covers advanced topics that establish the groundwork for understanding.

This proceedings constitutes the refereed proceedings of the 17th International Conference on Communications and Networking, ChinaCom 2022, held in November 19-20, 2022. Due to COVID-19 pandemic the conference was held virtually. The 31 full papers presented were carefully selected from 83 submissions. The papers are organized in topical sections on Signal Processing and Communication Optimization; Scheduling and Transmission Optimization; Network Communication Performance Enhancement; Deep Learning Applications and Optimization; Deep Learning and Network Performance Optimization; Edge Computing and Artificial Intelligence Applications.

The Beauty of Mathematics in Computer Science explains the mathematical fundamentals of information technology products and services we use every day, from Google Web Search to GPS Navigation, and from speech recognition to CDMA mobile services. The book was published in Chinese in 2011 and has sold more than 600,000 copies. Readers were surprised to find that many daily-used IT technologies were so tightly tied to mathematical principles. For example, the automatic classification of news articles uses the cosine law taught in high school. The book covers many topics related to computer applications and applied mathematics including: Natural language processing Speech recognition and machine translation Statistical language modeling Quantitive measurement of information Graph theory and web crawler Pagerank for web search Matrix operation and document classification Mathematical background of big data Neural networks and Google's deep learning Jun Wu was a staff research scientist in Google who invented Google's Chinese, Japanese, and Korean Web Search Algorithms and was responsible for many Google machine learning projects. He wrote official blogs introducing Google technologies behind its products in very simple languages for Chinese Internet users from 2006-2010. The blogs had more than 2 million followers. Wu received PhD in computer science from Johns Hopkins University and has been working on speech recognition and natural language processing for more than 20 years. He was one of the earliest engineers of Google, managed many products of the company, and was awarded 19 US patents during his 10-year tenure there. Wu became a full-time VC investor and co-founded Amino Capital in Palo Alto in 2014 and is the author of eight books.

This two volume set constitutes the refereed proceedings of the 14th EAI International Conference on Communications and Networking, ChinaCom 2019, held in November/December 2019 in Shanghai, China. The 81 papers presented were carefully selected from 162 submissions. The papers are organized in topical sections on Internet of Things (IoT), antenna, microwave and cellular communication, wireless communications and networking, network and information security, communication QoS, reliability and modeling, pattern recognition and image signal processing, and information processing.

This two volume set constitutes the refereed proceedings of the 14th EAI International Conference on Communications and Networking, ChinaCom 2019, held in November/December 2019 in Shanghai, China. The 81 papers presented were carefully selected from 162 submissions. The papers are organized in topical sections on Internet of Things (IoT), antenna, microwave and cellular communication, wireless communications and networking, network and information security, communication QoS, reliability and modeling, pattern recognition and image signal processing, and information processing.

This book presents the latest research on the software crowdsourcing approach to develop large and complex software in a cloud-based platform. It develops the fundamental principles, management organization and processes, and a cloud-based infrastructure to support this new software development approach. The book examines a variety of issues in software crowdsourcing processes, including software quality, costs, diversity of solutions, and the competitive nature of crowdsourcing processes. Furthermore, the book outlines a research roadmap of this emerging field, including all the key technology and management issues for the foreseeable future. Crowdsourcing, as demonstrated by Wikipedia and Facebook for online web applications, has shown promising results for a variety of applications, including healthcare, business, gold mining exploration, education, and software development. Software crowdsourcing is emerging as a promising solution to designing, developing and maintaining software. Preliminary software crowdsourcing practices and platforms, including Apple's App Store and TopCoder, demonstrate the advantages of crowdsourcing in terms of software ecosystem expansion and product quality improvement.