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To start with, we feel that we should explain why the book has been
entitled Cholera Toxins. In fact, the enterotoxin secreted by
Vibrio cholerae, which is p- marily responsible for causation of
the disease, is conventionally known as or referred to as cholera
toxin, or CT. By using the word "toxins" (in its plural form), we
wanted to cover all of the different types of toxins-and not just
CT-produced by V. cholerae. We could have used the title Toxins of
Vibrio cholerae, but we believe that Cholera Toxins is simpler and
equally as expressive. However, due to its relative importance, the
story of CT covers most of this book. Also, compared to all other
toxins of V. cholerae, CT has been investigated more extensively.
This book was jointly written by us. It is not a multiauthor book
in which each expert writes one chapter. In that respect our task
is harder. On the other hand, it has given us the unique
opportunity to present the entire subject in the way that we
conceived it. Besides, our objective is to cater to the needs of
not only active research scientists but also students from
different disciplines-microbiology, molecular physiology and
pharmacology, basic medicines, etc. -and as such, we have attempted
to present the subject in a way that will be appreciated by general
readers. Further, we have provided some information that students
and predoctoral researchers may find useful at the end of the book.
This book provides a detailed account of the physico-chemical
properties and biological functions of the outer membrane vesicles
(OMVs) of different pathogenic and non-pathogenic Gram-negative
bacteria. It also includes an authentic record of the first
systematic study that discovered the mechanism of OMV formation by
a pathogen, "Vibrio cholerae," and proposed that the process
represented a novel secretory activity of bacteria. Furthermore,
the authors present clinical and laboratory data on the use of OMVs
as immunogens, as effective and licensed vaccines against
"Neisseria meningitidis" serogroup B infections and on the
development of more effective vaccines against other human and
animal pathogens including "Vibrio cholerae. "This volume thus
bears witness to the emerging revolution in the field of vaccines
against pathogens and closes with a discussion of open questions
and future research on OMVs.
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