Is the first to present the historic background and numerous case studies on Moebius topology in mathematics, astronomy, chemistry, molecular medicine, physics and nanomaterials, literature, arts, and architecture Covers research on Moebius strip topology-controlled nanodevices for use in chemistry, biology, physics, and material sciences, including aspects from modern computer simulations for molecular design and engineering Highlights case studies on Moebius topology from the 18th-19th century up to the present years, taking examples from Europe, America, Australia, and Asia Reports on how drug-delivery techniques can be revolutionized through the development of topologically protected ring-shaped nanoproteins, such as Moebius-type cyclotides; the structural stability of such bioengineered nanodevices allows for better drug transport across the blood-brain barrier Reports on the spectacular modern architecture of buildings and bridges inspired by Moebius strip topology in Berlin, Amsterdam, Beijing, and Changsha Is richly illustrated with excellent figures to accompany each chapter and section Is authored by internationally renowned researchers in the field of magnetic resonance spectroscopy on complex (bio)chemical systems

Understanding the major factors determining the specificity of transmembrane transfer processes in proteins is now a hot topic in molecular bio-science. Advanced electron paramagnetic resonance (EPR) at high magnetic fields is a powerful technique for characterizing the transient states of proteins in action. High-Field EPR Spectroscopy on Proteins and their Model Systems: characterization of Transient Paramagnetic States offers a comprehensive overview of experimental techniques in, and paradigmatic examples of, the application of high-field EPR spectroscopy in biology and chemistry. The book's focus is on the use of the technique in conjunction with site-specific mutation strategies and advanced quantum-chemical computation methods to reveal protein structure and dynamics. This yields new insights into biological processes at the atomic and molecular level. The theoretical and instrumental background of high-field EPR is described and examples of paradigmatic protein systems, such as photosynthetic reaction centres, are discussed in the light of recent investigations. Aspects of structure dynamics-function relations that are revealed by studying site-specific mutants are highlighted, thereby combining high-field EPR with genetic engineering techniques. The information obtained complements that obtained from protein crystallography, solid-state NMR, infrared and optical spectroscopy. The book documents both background knowledge and results of the latest research in the field. Unique features include comparisons of information content of EPR, ENDOR, Triple resonance, ESEEM and PELDOR taken at different microwave frequencies and magnetic fields. Coherent treatment of the subject by the leading Berlin high-field EPR laboratory covers the theoretical background as well as state-of-art research both in terms of instrumentation and application to biological systems. The book provides an outlook to future developments and references for further reading and is essential reading for postdoctoral scientists, professionals, academics and graduate students working in this field.