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Cutting-edge investigators review the current status of the entire
field, from the biology of MMPs through the current clinical
studies. The authors include many leading scientists from
pharmaceutical companies who present all the latest concepts and
results on the preferred design strategies for MMP inhibitors,
their molecular mechanisms, and their substrates. In addition, they
fully describe their personal research on specific MMP inhibitors,
detailing vanguard design strategies, their in vitro activity, the
outcome of animal model studies and, where available, their
toxicology, safety, efficacy in human clinical trials.
Comprehensive and state-of-the-art, Matrix Metalloproteinase
Inhibitors in Cancer Therapy offers basic and clinical
investigators alike a richly informative summary of all the latest
research on these powerful new drugs, and their high promise as
emerging cancer therapeutics.
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