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This volume explores the epigenetic alterations and their
association with various human cancers. Considering one of human
cancer as an example, individual chapters are focused on defining
the role of epigenetic regulators and underlying mechanisms in
cancer growth and progression. Epigenetic alteration including DNA
methylation, histone modification, nucleosome positioning and
non-coding RNAs expression are involved in a complex network of
regulating expression of oncogenes and tumor suppressor genes and
constitute an important event of the multistep process of
carcinogenesis. Recent advances in the understanding of the
epigenetic regulation and detailed information of these epigenetic
changes in various cancers provide new avenues of advancements in
diagnostics, prognostics, and therapies of this highly fatal
disease.
This volume explores the epigenetic alterations and their
association with various human cancers. Considering one of human
cancer as an example, individual chapters are focused on defining
the role of epigenetic regulators and underlying mechanisms in
cancer growth and progression. Epigenetic alteration including DNA
methylation, histone modification, nucleosome positioning and
non-coding RNAs expression are involved in a complex network of
regulating expression of oncogenes and tumor suppressor genes and
constitute an important event of the multistep process of
carcinogenesis. Recent advances in the understanding of the
epigenetic regulation and detailed information of these epigenetic
changes in various cancers provide new avenues of advancements in
diagnostics, prognostics, and therapies of this highly fatal
disease.
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