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Among neuromodulation procedures, electrical stimulation of
peripheral nerves (PNS) is probably the most underappreciated
modality. Although PNS is used for all kinds of medical conditions,
ranging from chronic neuropathic pain and headache to epilepsy,
depression, hypertension and heart failure, its importance is
frequently overshadowed by spinal cord stimulation and deep brain
stimulation. While the earlier version of this book dealt
exclusively with various pain syndromes, this new volume covers the
entire spectrum of PNS applications. Written by recognized
authorities in their respective fields, the chapters of this title
describe the use of PNS in the management of neurological,
psychiatric, otorhinolaryngological, cardiovascular, pulmonary,
colorectal and genitourinary disorders. To reflect the complexity
of the regulatory process, the book ends with a special chapter
dedicated to the current state of approval of different PNS
devices. This book will be of great value to all those who deal
with neuromodulation, including clinicians who select PNS
candidates, surgeons and other specialists who implant PNS devices,
and researchers and engineers who work on making the stimulators
safer and more effective.
At present most intracranial gliomas are considered incurable with
current treatment strategies, and the search for new modalities
that may effectively control tumor growth continues. The chapters
in this volume describe basic principles and therapeutic
possibilities of several innovative techniques, including
photodynamic therapy, laser-induced interstitial thermotherapy,
stereotactic cryodestruction, high-intensity focused ultrasound
ablation, boron neutron capture therapy, proton and carbon ion
irradiation, targeted therapy, immunotherapy, gene therapy, local
chemotherapy, and alternating electric fields therapy. Potential
applications of extracellular vesicles and nanotechnology for
management of gliomas are highlighted as well. Many of these
methods have already demonstrated antitumor efficacy in clinical
testing, whereas others are still under development. The materials
presented in this book are mainly directed at clinicians treating
patients with brain tumors, as well as clinical and basic
researchers working in the field of neuro-oncology.
Treatment of patients with intracranial gliomas, especially
high-grade neoplasms, usually requires postoperative adjuvant
therapy. Significant progress in the understanding of tumor
biology, technological advances in irradiation delivery, and
development of novel antitumor drugs have led to an expansion of
the therapeutic arsenal in neuro-oncology. This publication
provides a unique review of the various options for adjuvant
therapy. Special emphasis is on current evidence-based treatment
standards and guidelines, and on perspectives of further
improvement in long-term outcomes. Chapters review the
histopathological and molecular features of gliomas and describe
basic principles and clinical results of fractionated radiotherapy,
stereotactic radiosurgery, brachytherapy, use of radiosensitizers,
systemic chemotherapy and antiangiogenic therapy. Particular
attention is paid to treatment of pediatric patients and to
physical and psychological rehabilitation and supportive care at
the end of life. This book and its accompanying volumes are mainly
directed at neuro-oncologists, radiation oncologists, and other
clinicians treating patients with brain tumors.
This book summarizes the current state of movement disorder
management and the role of surgical therapies as an alternative to
medication. Following a chapter on the history of movement disorder
surgery, leaders in their fields describe the pathophysiology,
functional neuroanatomy, clinical presentation, and medical
management of Parkinson's disease, dystonia, and essential tremor.
This is followed by chapters on the spectrum of movement disorder
surgery itself, from the lesioning procedures of radiofrequency
ablation, stereotactic radiosurgery, and high-frequency ultrasound
to the modulatory procedures of "asleep", image-guided deep brain
stimulation (DBS) and "awake", microelectrode-guided DBS. The final
chapters focus on closed-loop DBS, drug-delivery, gene therapy, and
other emerging neurosurgical therapies, highlighting long-standing
experimental strategies that are reaching exciting phases of
clinical translation. This volume is a valuable tool for accessing
the wide spectrum of concepts that currently define this dynamic
field.
This second edition is written by renowned experts in neurosurgery,
neurology, physics, and radiation oncology, many of whom are
pioneers of radiosurgery. Throughout more than 30 detailed
chapters, the authors share their vast expertise on this highly
precise, minimally invasive form of radiation therapy. The first
few chapters lay a foundation for understanding the
differentiations in types of SRS technology: Leksell Gamma Knife,
Novalis, Linac and Proton Beam Radiosurgery, and Cyberknife,
followed by an explanation on the physics and radiobiology of SRS.
The remaining chapters provide a detailed discussion of all
pathologies and disorders currently treated. Highlights:
Radiosurgical procedures for a wide range of intracranial
conditions/diseases including arteriovenous malformations,
meningiomas, pituitary adenomas, trigeminal neuralgia,
obsessive-compulsive disorder, epilepsy, ocular disorders,
pediatric brain tumors, and gliomas. Important updates on skull
base tumors, functional disorders, and brain metastases.
Evidence-based findings covering indications, patient selection,
benefits, limitations, outcomes, potential complications, and
alternative treatment modalities. This updated reference tool is an
invaluable, comprehensive guide to current concepts in SRS. It is a
must-have resource for neurosurgeons, radiation oncologists,
neuro-radiologists, and medical physicists, from residents to
advanced clinicians.
Since its introduction 52 years ago, Leksell radiosurgery has
become a widely applied technique for the management of a diverse
group of vascular, neoplastic, and functional disorders. This
publication presents an update on state-of-the-art radiosurgery
technology, including outcomes, by the pioneers in the field.
Experts have contributed chapters on various topics. They provide a
history of the development of Leksell Gamma Knife and its evolution
from frame-based to the inclusion of mask-based radiosurgery in the
latest Gamma Knife model. For beginners, there is valuable
information related to imaging, quality assurance, patient care,
anesthesia, and regulatory requirements. Advance users will
appreciate the summary of the long-term outcome of important
indications. Additional chapters on cavernous malformation,
orbital, uveal, and ocular disorders clarify the role of
radiosurgery. This book is a concise overview for physicians
interested in radiosurgery. It will be of great value to
neurosurgeons, radiation oncologists, and medical physicists
concerned with learning about the indications of radiosurgery.
Stereotactic radiosurgery is the least invasive of modern treatment
modalities and has recently become the basic management tool in
neurosurgery. Arteriovenous malformations, benign brain tumors and
brain metastases are the most common indications for its use. Also,
gamma knife radiosurgery is increasingly being applied to
extracranial pathologies, e.g. tumors of the spine and cancers of
the lung, liver, pancreas and prostate. Approximately one quarter
of patients undergoing gamma knife radiosurgery worldwide are
treated in Japan. This publication provides an excellent overview
of Japan's 20-year experience with stereotactic radiosurgery using
the Leksell Gamma Knife. Leading experts discuss their long-term
results with gamma knife radiosurgery. Studies focusing on dose
selection for optimal treatment results and avoidance of
complications are also presented. In addition, gamma knife
treatments of extracranial pathologies are reviewed. Neurosurgeons,
neurologists, oncologists and workers in radiology and cardiology
will find accurate knowledge on gamma knife radiosurgery which will
be helpful with patient selection, treatment planning and delivery,
and postoperative management.
As in any multiauthored textbook penned by When I was first
approached by the publisher of this volume, Martinus Nijhoff,
Boston, I writers of diverse backgrounds and interests, explored
the possibility of writing a personal Modern Stereotactic
Neurosurgery to some monograph on contemporary stereotactic extent
suffers from incompleteness. Future surgery. After a review of
available literature, volumes no doubt will include many additions
several aspects became apparent. First, no cur from other authors
who also are important rent, readily accessible, multiauthored text
de specialists in the field. Because not all authors signed to
survey the field was available. Those write in the same style (or
even language), we books that were available tended to heavily have
attempted to achieve a more cohesive text emphasize theory,
physiology, and anatomy. in the editorial process. Each chapter has
been Second, stereotactic surgeons were considered subdivided into
pertinent headings for easier abstruse and for too long were
relegated to a reference. Because of my own background, status
outside of the mainstream of neuro some readers will note an
Americanization (as surgery. This attitude probably reflected the
opposed to anglicization) of the chapters. insufficient explanation
of the practical uses While many chapters comprise primarily sum
and advantages of stereotactic technique. maries of the authors'
work within the field, Third, in recent years, the field has
expanded each author was encouraged to review the liter so rapidly
that it has become a major compo ature in that discipline if
appropriate."
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