This book intends to bring together researchers and developers from industry, the education field, and the academic world to report on the latest scientific research, technical advances, and methodologies. The 10th International Conference in Methodologies and Intelligent Systems for Technology Enhanced Learning is hosted by the University of L'Aquila and is going to be held in L'Aquila (Italy). Initially planned on the 17th to the 19th of June 2020, it was postponed to the 7th to the 9th of October 2020, due to the COVID-19 outbreak. The 10th edition of this conference and its related workshops expand the topics of the evidence-based TEL workshops series in order to provide an open forum for discussing intelligent systems for TEL, their roots in novel learning theories, empirical methodologies for their design or evaluation, stand-alone solutions, or web-based ones. This bridge has been realized also thanks to the sponsor of this edition of MIS4TEL: the Armundia Group https://www.armundia.com, the support from national associations (AEPIA, APPIA, CINI, and EurAI), and organizers (UNIVAQ, UNIROMA1, UNIBZ, UCV, UFSC, USAL, AIR institute, UNC, and UNIBA)