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New methods for the construction of condensed five-membered ring
systems continue to be developed at an accelerated pace. The
challenges underlying this tremendous current upsurge of interest
arise from several directions. One stems from the desire to
elucidate and resolve those special problems associated with the
incorporation of added strain not present when six-membered rings
are mutually fused. The many structurally interesting polyquinane
natural products isolated and characterized in recent years have
provided a particularly delightful forum for application of various
new synthetic protocols, many of which must equally well
accommodate the particular stereochemical demands of each indi
vidual target. Synthetic elaboration of a marvellous array of new
unnatural molecules also holds continued fascination. In the past,
we have attempted to keep others abreast of developments in this
rapidly burgeoning area by authoring a pair of comprehensive
reviews in Topics in Current Chemistry that appeared in 1979 [1]
and 1984 [2]. During this period, others have also surveyed the
developments in cyclopentannulation [3] and the cyclopentanoid
field in general [4]. In the last couple of years, the pace at
which new synthetic facets have been reported has become more
frenetic than ever before. Accordingly, a suitable updating of the
exciting newer findings was deemed appropriate and the present
overview, which extends approximately to mid - 1986, was written.
Once again, our hope is that compilations of this type will serve
to stimulate imaginative new scientific ventures that will propel
the field forward to still greater maturity.
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