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The book gathers lecture notes of courses given at the 2014 summer
school on integrated biology in Les Houches, France, Session CII.
It addresses an emerging field ranging from molecules to cells and
to organisms. Through examples it presents a new way of thinking
using a combination of interdisciplinary and cutting-edge methods,
bridging physics and biology beyond current biophysics. Important
novel developments are expected in the coming years that may well
introduce paradigm shifts in biological science. The school had the
ambition to prepare participants to become major actors in these
breakthroughs. The power of integrated approaches is illustrated
through two cases: interactions between viruses and host cells, and
flower development. The role of forces in biology, as well as their
mathematical modeling, is illustrated in both processes: how they
allow flower organs to emerge or how they control membrane fusion
during virus budding. The book also underlines the importance of
conformational changes and dynamics of proteins particularly during
membrane processes. It explains how membrane proteins can be
handled and studied by molecular simulations. Finally, the book
also contains concepts in cell biology, in thermodynamics and
several novel approaches such as in-cell NMR. Altogether, the
chapters show how examining a biological system from different
viewpoints based on multidisciplinary aspects often leads to
enriching controversial arguments.
This book collects lecture courses and seminars given at the Les
Houches Summer School 2010 on "Quantum Theory: From Small to Large
Scales." Fundamental quantum phenomena appear on all scales, from
microscopic to macroscopic. Some of the pertinent questions include
the onset of decoherence, the dynamics of collective modes, the
influence of external randomness and the emergence of dissipative
behaviour. Our understanding of such phenomena has been advanced by
the study of model systems and by the derivation and analysis of
effective dynamics for large systems and over long times. In this
field, research in mathematical physics has regularly contributed
results that were recognized as essential in the physics community.
During the last few years, the key questions have been sharpened
and progress on answering them has been particularly strong. This
book reviews the state-of-the-art developments in this field and
provides the necessary background for future studies. All chapters
are written from a pedagogical perspective, making the book
accessible to master and PhD students and researchers willing to
enter this field.
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Paperback
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R398
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Discovery Miles 3 300
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