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Ureases: Foundations, Classes, and Applications provides a
thorough, practical analysis of ureases—enzymes of growing
relevance across a range of biotechnological applications and drug
discovery. Unique in many aspects, ureases are one of the few
enzymes to have nickel in their active sites. Ureases covers all
aspects of this enzymatic class. Starting with foundational
overview, the book discusses historical urease research and the
current state, from basic biochemistry to the use of ureases as
hallmarks in enzymology, crystallography, and bioinorganic
chemistry. The different classes of ureases, structurally diverse
but chemically equivalent, are individually discussed. The
multi-protein, multi-step activation of ureases (with chemical
modification of residues, transport, and transfer of nickel ions)
are examined in-depth, along with the catalytic mechanisms of
ureolysis and its inhibitors. The final two sections of the book
address multiple applications of ureases in health and
biotechnology, respectively, going from gastric ulcer treatment to
architectural uses in buildings and engineering. Future
applications and next steps in research are also considered.
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