When Charles Miller Fisher was born in 1913 there was very little scientific knowledge about stroke. But thanks to him, our understanding of stroke and of other brain disorders are now well established in every neurology training program around the world. C. Miller Fisher is his story: his life, his method of study and of research, and his contributions. This work, reinforced with unequalled access to the CMF archives overseen by the Fisher estate and told in his own words (italicized in the text) from his memoirs, will shed light on one of the most important clinicians in North America and the world. He devoted his career and the great majority of every waking day to the study of stroke, both in the pathology laboratory and in people. Fisher's discoveries and contributions and those of the individuals that he trained changed the knowledge basis of stroke and vascular disease for everyone.

Primer on Cerebrovascular Diseases, Second Edition, is a handy reference source for scientists, students, and physicians needing reliable, up-to-date information on basic mechanisms, physiology, pathophysiology, and medical issues related to brain vasculature. The book consists of short, specific chapters written by international experts on cerebral vasculature, presenting the information in a comprehensive and easily accessible manner. Numerous changes have occurred in the field since the publication of the first edition in 1997, particularly our understanding of the genetic aspects of cerebrovascular disease. This updated edition reflects the advances made over the last two decades, not only demonstrating the promise for therapy, but also for a molecular understanding of cerebrovascular diseases. The new edition includes new and expanded topics, including carotid stenting, Iatrogenic causes of stroke, axonal transport and injury, RNAIs, proteomics, and more. 2018 BMA Medical Book Awards Highly Commended in Neurology.

Stroke is one of the most important and most feared conditions known to man. The threat of stroke is important to all people. What could be more devastating than to lose the ability to speak, move a limb, stand, talk, see, read, feel write or even think? This book brings together ideas, events and advances - the stories - before and during the 20th Century through the accounts of global experts in the field, many of them having been first-hand witnesses to progress. Focusing on selected stories of stroke, this book offers a readable summary of the most dramatic and extensive changes in knowledge about stroke and in caring for stroke patients. Of interest to anyone interested in neurosciences and for physicians caring for stroke patients, this book informs on moving forward, by looking to how we got to where we are.

The brain stem and cerebellum are structures that have fascinated and puzzled physicians, anatomists, and physio- logists for centuries. Relatively small in volume compared to the much larger and more majestic human cerebrum, and hidden away in relative obscurity in the back of the head under the protection of the bony posterior fossa and the firm dural envelope, the tentorium cerebelli, these critical neural structures defied precise study during life until very recently. Recent advances in brain and vascular imaging and improved understanding of brain-stem reflex and tract functions and their measurement by electrophysiological techniques have presented an opportunity for clinicians and researchers to better study, during life, patients with stroke and other conditions that involve the brain stem and cere- bellum. A congress was held at the Neurology Clinic of the University in Mainz, April 4-5, 1992, during which clinicians and researchers reported and discussed modern topical diagnosis of diseases of the brain stem and cere- bellum. This volume represents the edited proceedings of that congress. Early information about brain stem anatomy and func- tions came from anatomical studies by Ludwig Turk, Paul Flechsig, Rudolph von K6lliker, Karl Burdach, Vladimir Bekterew, and Benedikt Stilling, among others, all working in Germany during the middle years of the nineteenth century. Johann Reil, a German anatomist, in the begin- ning of the nineteenth century had described the structure and some functions of the cerebellum which he called the little brain ("Kleinhirn").

The topography of the brainstem is complex, and even experienced neurologists find it challenging to localize brainstem lesions and diagnose brainstem disorders. This richly illustrated book provides a comprehensive review of brainstem disorders and presents the clinical knowledge necessary for diagnosis. The opening sections document the brainstem neuroanatomy and discuss current diagnostic methods. The entire spectrum of clinical findings in brainstem disorders is then described, and topodiagnostic aspects of the neurological findings are explained in detail. The descriptions of brain stem disorders are consistently structured and are supported by many MR images and short case reports. In addition to primary brainstem lesions, such as vascular brainstem syndromes, other disorders are considered that do not exclusively show brainstem symptoms or signs, e.g., multiple sclerosis. This book will serve as an invaluable reference work for neurologists in clinical practice or further education.

This comprehensive review of vascular disease in the vertebrobasilar circulation is based on Dr Louis R. Caplan's extensive experience and observation of patients from the New England Medical Center posterior circulation stroke registry. It benefits from an organized, uniform, and coherent analysis of all types of vascular disease involving the posterior circulation, presented by a single author who is one of the world's leading authorities on this topic. This new edition is fully updated throughout, including a review of all the literature published on this topic since the previous edition in 1996. There are major rewrites for the chapters on diagnosis and therapy, inclusion of modern imaging techniques, and extensive illustrations. Essential reading for stroke physicians and neurologists, the book will also be an important source of reference for neurosurgeons, vascular surgeons and endovascular radiologists.

Strokes afflict thousands of people every year. Yet, for every fatal case, many more victims survive, often going on to live long, productive lives. Of course, none of it is simple-not preventing a "brain attack," nor survival, rehabilitation, or living with cerebrovascular disease. The key is education, for both the moment of crisis and the long term. Navigating the Complexities of Stroke provides a practical guide for the lay public and medical professionals. Dr. Louis R. Caplan, one of the world's leading experts, guides readers through the subject in a straightforward and accessible manner. He examines the anatomy of the brain, explaining the specialized functions of different regions, and describes the flow of blood from the heart. He turns to the mechanics of the stroke itself, clearly discussing the complexities of the two major kinds-the ischemic and hemorrhagic-and the resulting damage. Most helpfully, Caplan offers information and advice that readers will find immediately useful: the medical conditions and other factors that create risk, stroke symptoms, abnormalities that doctors look for, tests available to evaluate strokes, complications and disabilities that can result, and the paths of treatment and rehabilitation. He offers real-life cases of victims and their families that demonstrate successful recovery, but also reveal the sometimes troubling impact of strokes on survivors and their families, who can suffer frustration and demoralization that the medical profession often overlooks in its biological focus. Caplan also examines strokes in children and young adults, who are often neglected in literature that is largely aimed at seniors. Navigating the Complexities of Stroke empowers victims, families, and general medical providers. It puts in readers' hands the knowledge necessary to avoid strokes, address them quickly, and effectively recover, so they won't lose heart when it is needed most.

Neurologists learn from their patients, and this selection of 60 stroke cases will inform and challenge clinicians at all stages in their careers. Including both common and unusual cases, the aim is to reinforce diagnostic skills through careful analysis of individual presenting patterns, and to guide treatment decisions. Each case consists of a clinical history, examination findings and special investigations, usually involving imaging before a diagnosis is given. There then follows for each case a discussion of the clinical issues raised by the case, in which the main teaching points are emphasized. Selected references, frequently including the first description, are provided at the conclusion of each case. Drawing on the expertise of leading teachers and practitioners, and liberally illustrated, these case studies and the discussions that accompany them are an essential guide to learning the complexity of stroke diagnosis.

Stroke is the leading cause of permanent disability, including post-stroke dementia, pain, depression, and personality changes. While large clinical trials reflect information about large stroke populations, the presentation of each and every stroke patient is individual and special. More Case Studies in Stroke presents a new selection of stroke cases from seven countries prepared by practising stroke physicians. The book includes both common and unusual cases, as well as misleading cases of diseases mimicking stroke. The aim is to reinforce diagnostic skills through careful analysis of individual presenting patterns, and to guide treatment decisions. Each case consists of a clinical history, examination findings and special investigations, followed by diagnosis and discussion. The outline of the actual diagnostic process, including the use of modern diagnostic tools, decision making and course, challenge the reader at all stages of their career from medical students to neurologists and stroke physicians.