Neurobiology of the Placebo Effect, Part II, Volume 139, the latest release in the International Review of Neurobiology series, is the second part of a two-volume set that provides the latest placebo studies in clinically relevant models. Specific chapters cover the History of placebo effects in medicine, Lumping or Splitting: Towards a taxonomy of placebo and related effects, Theories and brain mechanisms of placebo analgesia, Pain Modulation: From CPM to placebo and nocebo effects in experimental and clinical pain, Modulation of the motor system by placebo and nocebo effects, and the role of sleep in learning placebo effects, amongst other topics.

Neurobiology of the Placebo Effect, Part I, Volume 138 in the International Review of Neurobiology series, is the first of two volumes that provide the latest placebo studies in clinically relevant models. Placebo responses effects are not merely a psychological, but a complex psycho-neuro-biological process that requires activation of distinct brain areas. This book discusses current research and projects on the involved brain circuitry and neurotransmitter systems. Specific chapters cover such topics as pharmacological conditioning of the endocrine and immune system, expectancy modulation of opioid neurotransmission, nocebo effects in visceral pain, and conditioning as a higher-order cognitive phenomenon, amongst other topics.

The placebo effect continues to fascinate scientists, scholars, and clinicians, resulting in an impressive amount of research, mainly in the field of pain. While recent experimental and clinical studies have unraveled salient aspects of the neurobiological substrates and clinical relevance of pain and placebo analgesia, an authoritative source remained lacking until now. By presenting and integrating a broad range of research, "Placebo and Pain" enhances readers knowledge about placebo and nocebo effects, reexamines the methodology of clinical trials, and improves the therapeutic approaches for patients suffering from pain.

Review for "Placebo and Pain: " " This ambitious book is the first comprehensive and unified presentation of the placebo and nocebo phenomena in the area of pain. Written by the international leading experts in the field, the book provides an accurate up-to-date work] on placebo and pain dealing with current perspectives and future challenging issues. --Ted Kaptchuk, " Associate Professor of Medicine, Harvard Medical School
Contains historical aspects of the placebo effectDiscusses biological and psychological mechanisms of placebo analgesic responsesReviews implications of the placebo effect for clinical research and pain managementIncludes methodological and ethical aspects of the placebo effect"

Placebo Effects Through the Lens of Translational Research is an Open Access book integrating current knowledge on placebo research in healthcare to develop comprehensive and adequate strategies for better symptom management and treatment responses. This edited collection features the work of experts in placebo studies, including women, people of color, and international scholars, helping to diversify the existing scholarship in the field. It presents the latest research findings while also considers theoretical aspects of placebo. Together, the chapters in this volume help bridge the gulf between research and ideas in placebo studies and their day-to-day application in clinical practice in order to improve healthcare and health outcomes. Responses to placebos can be as significant as the observed results of active treatments in Phase II/III randomized clinical trials. These results have led to a stagnant era in new drug development since the effect of these potential therapeutics have similar, measured effects as the placebos used in the same trials. This book sheds light on translational aspects related to placebo and drug treatment methods. It also evaluates the clinical implications of a much-needed integration of pharmacological and nonpharmacological treatments in healthcare. Placebo Effects Through the Lens of Translational Research concludes with a discussion of the most innovative developments in placebo research, which will be of interest to a wide readership, including clinicians, senior scientists, trainees, and patients. In a single volume, Placebo Effects Through the Lens of Translational Research provides readers with an overview of current perspectives on placebo research and translational applications.