Due to changes made in 2018 to the Department of Health Standard Treatment Guidelines and Essential Medicines List, the Primary Clinical Care Manual has been substantially revised to meet the educational requirements of current nursing students. The 10th edition of Primary Clinical Care Manual has been updated with all the fundamental changes necessary for students to have up-to-date, relevant information needed for primary health care in South Africa. Such additions and changes include: 1. The 2018 edition of the Department of Health Primary Care Standard Treatment Guidelines (STGs) and Essential Medicines List (EML). It also includes information obtained from the Hospital Level STGs and EML. 2. Seven chapters have been extensively rewritten and/or updated: Hypertension, with a new section on postnatal patient management; HIV and AIDs patients; Contraception; Epilepsy; The Skin; Joints; Mental Health; 3. Numerous medicine and dosage changes have been made in accordance with Department of Health (DOH) recommendations. More clarity on referral criteria is provided in relevant chapters. While other versions of the Primary Clinical Care Manual will be discontinued, this revised edition will be available in March 2019.