World-renowned experts share the latest updates in translational research as well as surgical and nonsurgical strategies for treating spinal cord injury Spinal cord injury (SCI) is a devastating, clinically challenging injury, leading to varying degrees of neurological function impairment and paralysis. Underlying biological mechanisms either inhibit or promote new growth in the spinal cord. Researchers have been making important discoveries about how neurons and their axons grow in the central nervous system and why they fail to regenerate after SCI. Although progress has been steady, there remains an urgent need to address issues in acute management such as early decompression and the use of biologics, as well as potential solutions for regeneration. Written by renowned experts in the ever-evolving field of SCI research and clinical practice, the 7th volume in the AOSpine Masters series is a state-of-the-art compendium on the latest in SCI diagnosis, spine surgery interventions, and long-term management. Each chapter contains pearls from leading spine specialists gleaned from the research laboratory and years of hands-on experience treating SCI patients in the emergency setting and long term. Key Features: Pathobiology, assessment, and diagnostic considerations The use of biomarkers as predictors of functional recovery Surgical and nonsurgical interventions for traumatic SCI The role of neural stem cells and biologics in spinal cord repair Functional and epidural stimulation and brain-computer interfaces The AOSpine Masters series, a copublication of Thieme and the AOSpine Foundation, addresses current clinical issues featuring international masters sharing their expertise in the core areas in the field. The goal of the series is to contribute to an evolving, dynamic model of evidence-based approach to spine care. This essential textbook delivers invaluable insights to spine surgeons, spinal cord injury clinicians and researchers and trainees, from translational researchers to experienced researchers and clinicians experienced in the operative and non-operative management of spinal cord injury.

Renowned spine experts share recent advances on the management of spinal infections AOSpine Masters Series, Volume 10: Spinal Infections is a concise, state-of-the-art review covering all aspects of spinal infections – from basic science and epidemiology to fundamental surgical and nonsurgical approaches. Internationally renowned spine surgeons Luis Roberto Vialle, S. Rajasekaran, Rishi Kanna, Giuseppe Barbagallo, and many experts across the world, provide clinical pearls and insights gleaned from years of hands-on expertise. This book provides discussion of underlying pathologies, imaging and diagnosis, and surgical techniques, with a focus on issues specific to children, co-infection with HIV, postoperative problems, geriatric patients, and pseudoarthrosis. Key Highlights Overviews on the epidemiology, microbiology, and pathology of spinal infections Detailed review of imaging, and other investigations Treatment planning and surgical techniques Risk stratification and prevention of post-operative infection Pathogenesis, clinical features, diagnosis, and treatment of pyogenic spondylodiscitis in various regions of the spine Clinical pearls on the management of spinal tuberculosis, including drug therapy and surgery The AOSpine Masters series, a co-publication of Thieme and the AOSpine Foundation, addresses current clinical issues featuring international masters sharing their expertise in the core areas in the field. The goal of the series is to contribute to an evidence-based approach to spine care. This textbook is essential reading for all spine surgeons. Orthopaedic and neurosurgery residents, as well as veteran surgeons will find this a useful tool for daily practice.

An estimated 9 million children every year are affected by pediatric spinal deformities, encompassing a broad spectrum of pathologies. New classification systems, innovative imaging modalities, and advances in surgical techniques have contributed to a continually evolving, evidence-based treatment paradigm. Patient variables such as the age of onset, severity, course of deformity progression, as well as the availability of technology pose individualized challenges. AOSpine Masters Series, Volume 9: Pediatric Spinal Deformity is a concise yet comprehensive review of fundamental surgical and nonsurgical approaches, contemporary issues, and treatment obstacles. Internationally renowned spine surgeons Luis Roberto Vialle, Marinus de Kleuver, and Sigurd Berven and a cadre of esteemed contributors deliver a state-of-the-art reference on deformities of the pediatric spine. From early childhood to adolescent spine disorders, 17 richly illustrated chapters cover diagnosis, preoperative evaluation, imaging, spine surgery interventions, non-fusion procedures, and long-term management. Key Highlights Overviews on the classification and natural history of early onset scoliosis and adolescent idiopathic scoliosis, with subsequent chapters covering non-operative management and contemporary surgical techniques Evidence-based discussion of long-term surgical care outcomes, indications for revision surgery, and strategies for achieving optimal results Management of congenital and developmental kyphosis, lordosis, syndromic conditions, and low and high grade spondylolisthesis Clinical pearls on spine surgery in the developing world, safety issues and complications, and the importance of developing outcome metrics The AOSpine Masters series, a copublication of Thieme and the AOSpine Foundation, addresses current clinical issues featuring international masters sharing their expertise in the core areas in the field. The goal of the series is to contribute to an evolving, dynamic model of evidence-based approach to spine care. This outstanding textbook is a must have for spine surgeons, in particular those who specialize in treating childhood spine disorders. Orthopaedic and neurosurgery residents, as well as veteran surgeons with extensive knowledge will find this an indispensable tool for daily practice.

An evidence-based guide to managing primary tumors of the spine" This second volume in the AOSpine Masters Series balances critical appraisal of current evidence in spine oncology with the opinions of experienced spine surgeons to create a unique clinical reference for spine oncology surgeons. The book provides expert guidance to help clinicians make the right treatment decisions and provide the best care for their patients. The chapters have been written and researched by key leaders in spine oncology and range from general evaluation, staging, and decision making principles to histology-specific oncologic patient management. Key Features: Editors are internationally-recognized authorities on the treatment of primary spine tumors Synthesizes the best available evidence and consensus expert advice on primary spine tumors, leading to optimal clinical recommendations Each chapter includes clinical pearls, tips on complication avoidance, and "top 5 must-read references" The AOSpine Masters Series, a co-publication of Thieme and the AOSpine Foundation, addresses current clinical issues whereby international masters of spine share their expertise and recommendations on a particular topic. The goal of the series is to contribute to an evolving, dynamic model of an evidence-based medicine approach to spine care. All neurosurgeons, orthopedic surgeons, neuro-oncologists, and orthopedic oncologists specializing in spine, along with residents and fellows in these areas, will find this book to be an excellent resource that they will often refer to in their treatment of patients with primary tumors of the spine.

A focused guide from the world's experts on metastatic spine tumors" This first volume in the AOSpine Masters Series integrates the expertise of oncologists and radiology interventionalists with that of master spine surgeons, all of whom are actively involved in the care of patients with metastatic spine tumors. The book provides expert guidance to help clinicians make the right treatment decisions and provide the best care for their patients. Chapter topics range from evaluation and decision-making principles to a spectrum of non-operative and operative treatment options that have been rapidly evolving over the past decade. Key Features: Editors are internationally-recognized authorities on metastatic spine tumors Includes contributions from key opinion leaders working in spine oncology Synthesizes the best available evidence and consensus expert advice on metastatic spine tumors, leading to optimal clinical recommendations Each chapter includes clinical pearls, tips on complication avoidance, and "top 5 must-read references" The AOSpine Masters Series, a co-publication of Thieme and the AOSpine Foundation, addresses current clinical issues whereby international masters of spine share their expertise and recommendations on a particular topic. The goal of the series is to contribute to an evolving, dynamic model of an evidence-based medicine approach to spine care. All neurosurgeons, orthopedic surgeons, neuro-oncologists, and orthopedic oncologists specializing in spine, along with residents and fellows in these areas, will find this book to be an excellent guide that they will consult often in their treatment of patients with metastatic spine tumors.