During the 10 years since the last edition of Histopathology of Non-Hodgkin's Lymphomas, based on the updated Kiel classification, our knowledge on malignant lymphomas, especially on extranodal lymphomas, has increased. This volume - Histopathology of Nodal and Extranodal Non-Hodgkin's Lymphomas - is an expanded and completely revised edition, now based on the WHO classification. The parallels to the updated Kiel classification and the REAL classification are indicated. The information is organized in organ-specific chapters, comprising the well-known nodal lymphoma entities as well as all known extranodal lymphomas and the different organ-specific clinico-pathological entities: lymphomas of the spleen, the gastrointestinal tract, the skin, etc. In addition to the morphology, the major immunohistochemical, molecular genetic, and clinical data are included in each chapter.

Kurz nach Erscheinen unseres Handbuchs iiber die Non-Hodgkin-Lymphome wurden Stimmen laut, die nach einem klein en handlichen AbriB der Lymphom- diagnostik riefen. Auch die Mitglieder des Europiiischen Lymphom-Clubs (1. DIEBOLD, Paris, R. GERARD-MARCHANT, Villejuif, Y. KAPANCI, Genf, G. KE- LENYI, Pecs, H. NOEL, Briissel, F. RILKE, Mailand, A.G. STANSFELD, London, und J.A.M. VAN UNNIK, Utrecht) bestiirkten mich darin, einen solchen Ratgeber fUr den diagnostischen Alltag zu schreiben. Ja sie identifizierten sich mit diesem Plan und stell ten sich fUr die Obersetzung in mehrere Sprachen zur VerfUgung. So habe ich J. DIEBOLD, R. GERARD-MARCHANT, F. RILKE und A.G. STANSFELD fUr die prompte Obertragung ins Franzosische, Italienische und Englische zu danken. F. RILKE iibernahm die Initiative, einen Beitrag zur "Working Formula- tion for Clinical Usage" zu verfassen. Obersetzungen in weitere Fremdsprachen wurden von ehemaligen Mitarbeitern und befreundeten Kollegen bereitwillig durchgefUhrt, so von A. LLOMBART BOSCH ins Spanische, von IRENE LORAND und J.M. MACHADO ins Portugiesische und von N. MOHRI ins Japanische. Das Erscheinen in verschiedenen Sprachen einschlief3lich meiner Muttersprache sollte den Gebrauch des Abrisses im Alltag we iter erleichtern.

The 1st Edition of Histopathology of Non-Hodgkin's Lymphomas, written in col laboration with Professor H. STEIN and published in 1981, was received well and is now out of print. In the meantime, there has been an explosion of data that not only have made the definitions of various entities more precise but, above all, have confirmed the main entities originally delineated in the Kiel classification. The development of monoclonal antibodies and molecular cytogenetics has also made it possible to identify T-cell lymphomas more accurately. For example, many of the malignant lymphomas that were previously considered to be unclas sifiable can now be included in a classification scheme that places the T-cell lymphomas alongside of the list of B-cell lymphomas. In 1988 the European Lymphoma Club published an "updated Kiel classification" (STANSFELD et al. 1988) based on this new knowledge. It includes a number of previously undefined types of T-cell lymphoma. Studies done in Japan (T. SUCH! et al.) and China (L. Y Tu) have contributed to the understanding of these lymphoma types.