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CNRS International Colloquium, Held in Paris on June 22-24, 1977
We have studied 24 cases of secondarily leukemic (stage V)
lymphosarcoma (LS), 31 cases of "d'emblee" leukemic LS, and ten
cases of lymphoid leukemic neoplasias transitional between
"d'emblee" leukemic LS and chronic lymphocytic leukemia (eLL).
These cases only concern the common types ofthe WHO classification
ofLS, i.e., the prolymphocytic, the lymphoblastic, and the
immunoblastic. Some cases have also been classified by cell surface
markers. The secondarily leukemic conversion occurred in 40% of the
lymphoblastic types, in 14% of the prolymphocytic types, and in 17%
of the immunoblastic types. It never occurred at stage I but could
occur after any other stage. The mediastinal involvement was
observed in three types, but most often in the lymphoblastic type.
The prognosis after an acute lymphoid leukemia (ALL) treatment
comprising active immunotherapy following chemo(radio)therapy is
better for the leukemic prolymphocytic and lymphoblastic LS than
for the immunoblastic type. Two patients (one of the lymphoblastic
type) are in complete remission after 8 and 5 years, respectively.
We have described ten cases of "d'emblee" leukemic LS with either
large lymphoid or extra lymphoid masses, bone marrow leukemic cell
involvement, and LS aspects of neoplastic cells. Mediastinal,
abdominal, or other tumor masses are frequent."
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