The enormous importance of the diseases of the locomotor system in all populations and the large component of general clinical practice which they represent have not, in the past, been matched by an appropriate pathological effort. Increasing expectation of an active and long life has resulted in a great increase in specialisation in Rheumatology and rehabilitation of those with crippling diseases. This volume presents many of the pathological advances that have followed this clini cal interest, beginning with reviews of changes in biological materials obtained by in vasive investigation of joints, continuing with an account of therapy Goint replace ment) and also describing a "new" hazard - hyperbaric injury. Experimental models of joint disease are also described as are other entities such as crystal deposition dis ease. A detailed consideration of the electron microscopy of bone tumours is included since this data is not widely available in current texts. Finally, the role of the HLA system in rheumatic disease is included, indicating the value of close co-operation between clinician and pathologist in defining and link ing the various rheumatic syndromes. London Contents Examination of Synovial Fluid. With 9 Figures P.A. Revell ........................................... . The Synovial Biopsy. With 20 Figures F. Eulderink. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 25 Tissue Reactions to Joint Prostheses and the Products of Wear and Corrosion. With 20 Figures P.A. Revell. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 73 Bone and Joint Diseases in Workers Exposed to Hyperbaric Conditions."

New methods for the construction of condensed five-membered ring systems continue to be developed at an accelerated pace. The challenges underlying this tremendous current upsurge of interest arise from several directions. One stems from the desire to elucidate and resolve those special problems associated with the incorporation of added strain not present when six-membered rings are mutually fused. The many structurally interesting polyquinane natural products isolated and characterized in recent years have provided a particularly delightful forum for application of various new synthetic protocols, many of which must equally well accommodate the particular stereochemical demands of each indi vidual target. Synthetic elaboration of a marvellous array of new unnatural molecules also holds continued fascination. In the past, we have attempted to keep others abreast of developments in this rapidly burgeoning area by authoring a pair of comprehensive reviews in Topics in Current Chemistry that appeared in 1979 [1] and 1984 [2]. During this period, others have also surveyed the developments in cyclopentannulation [3] and the cyclopentanoid field in general [4]. In the last couple of years, the pace at which new synthetic facets have been reported has become more frenetic than ever before. Accordingly, a suitable updating of the exciting newer findings was deemed appropriate and the present overview, which extends approximately to mid - 1986, was written. Once again, our hope is that compilations of this type will serve to stimulate imaginative new scientific ventures that will propel the field forward to still greater maturity.

Complications in Surgery, Second Edition offers authoritative recommendations for preventing and managing complications in all current general surgery procedures. The opening sections discuss institutional risk management issues and risks common to all operations, such as wound healing problems, infection, shock, and complications in immunosuppressed patients. Subsequent sections focus on complications of specific procedures in thoracic, vascular, gastric, endocrine, breast, and oncologic surgery, as well as organ transplantation and pediatric surgery. This edition includes new information on surgical quality assessment and patient safety and updated information in the organ-specific chapters.

Annual Reports in Medicinal Chemistry continues to focus on providing timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.
Sections I-IV are disease orientated and generally report on specific medicinal agents.
Sections V and VI continue to emphasize important topics in medicinal chemistry, biology, and drug design.
* Annual comprehensive reviews of the past year literature in many topics of interest to medicinal chemists
* Includes a comprehensive set of indices to easily locate topics in Volumes 1-38 of this series
* Provides critical review on hot topics in medicinal chemistry

Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences which are expected to provide the basis for entirely new future therapies.