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Cancer is a complex disease. Only 5-10% of human cancers are
hereditary in nature. Many of us think of environmental agents when
we think of carcinogens. The environment includes all that
surrounds us, and environmental influences include not only
chemical, physical and biological toxicants, but also diet and
lifestyle. In this broadest sense, the environment contributes
substantially in the development of human cancer. This book will
describe how environment contributes to malignant transformation
leading to profound changes in the genetic and signaling networks
that control the functioning of the cell. It will critically
discuss the understanding of the effects of environment on the
development, progression and metastasis of cancer with current
knowledge of the signaling networks that support functioning of
transformed human cells. Genes and environmental factors that
influence the origins of cancer are not necessarily the same as
those that contribute to its progression and metastasis.
Susceptibility gene variants for each specific cancer are being
identified with emerging evidence of gene environment interaction.
Gene-environment interactions will be discussed through each
specific cancer-based approach to address the question of how
genetic variations can influence susceptibility to the individual
type of cancer. It will also highlight and summarize epigenetic
changes that increase the risk for susceptibility to a particular
type of cancer, particularly in the presence of specific
environmental factors. Thus, this book will contain chapters from
the world s experts focused on the current evidences that support
the role of environment in the cancer etiology and in the growth of
malignant lesions, and discuss who may be susceptible to
environmental influences."
Cancer is a complex disease. Only 5-10% of human cancers are
hereditary in nature. Many of us think of environmental agents when
we think of carcinogens. The environment includes all that
surrounds us, and environmental influences include not only
chemical, physical and biological toxicants, but also diet and
lifestyle. In this broadest sense, the environment contributes
substantially in the development of human cancer. This book will
describe how environment contributes to malignant transformation
leading to profound changes in the genetic and signaling networks
that control the functioning of the cell. It will critically
discuss the understanding of the effects of environment on the
development, progression and metastasis of cancer with current
knowledge of the signaling networks that support functioning of
transformed human cells. Genes and environmental factors that
influence the origins of cancer are not necessarily the same as
those that contribute to its progression and metastasis.
Susceptibility gene variants for each specific cancer are being
identified with emerging evidence of gene-environment interaction.
Gene-environment interactions will be discussed through each
specific cancer-based approach to address the question of how
genetic variations can influence susceptibility to the individual
type of cancer. It will also highlight and summarize epigenetic
changes that increase the risk for susceptibility to a particular
type of cancer, particularly in the presence of specific
environmental factors. Thus, this book will contain chapters from
the world's experts focused on the current evidences that support
the role of environment in the cancer etiology and in the growth of
malignant lesions, and discuss who may be susceptible to
environmental influences.
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