This volume constitutes the refereed proceedings of the 6th Workshop on Engineering Applications, WEA 2019, held in Santa Marta, Colombia, in October 2019. The 62 revised full papers and 2 short papers presented in this volume were carefully reviewed and selected from 178 submissions. The papers are organized in the following topical sections: computer science; computational intelligence; bioengineering; Internet of things; power applications; simulation systems; optimization.