0
Your cart

Your cart is empty

Browse All Departments
  • All Departments
Price
  • R500 - R1,000 (1)
  • -
Status
Brand

Showing 1 - 1 of 1 matches in All Departments

Human Experimental Therapeutic Models in Opioid Dependence (Paperback, New): Mark Greenwald Human Experimental Therapeutic Models in Opioid Dependence (Paperback, New)
Mark Greenwald
R866 Discovery Miles 8 660 Ships in 12 - 19 working days

This book selectively discusses recent advances in human experimental models relating to the treatment of opioid dependence. The author critically reviewed three independent lines of research conducted during the past decade with heroin-dependent volunteers. One research strategy involves studying the -opioid receptor ( OR), which is the molecular target for the reinforcing and physical dependence producing effects of heroin-like drugs. This has been accomplished by varying medication dose conditions, measuring the availability of brain -receptors in vivo and plasma pharmacokinetics, then correlating these biological concentration measures with clinically relevant endpoints including opioid withdrawal symptoms, heroin craving, and blockade of the euphoric and respiratory depressant effects of -agonist challenges. These studies provide an initial benchmark for estimating OR occupancy or plasma concentration requirements for effective pharmacotherapy. A second research strategy determines the conditions under which -agonist medications function as reinforcers, and the ability of medication dose and the availability of non-drug alternative reinforcement to attenuate opioid choice. Taken together, these studies provide information relevant to the ability of the medication to stimulate adherence and reduce drug demand. A third research strategy seeks to determine whether non-opioid medications can attenuate the naloxone-precipitated (i.e. withdrawal related) discriminative stimulus, subjective and/or physiological effects in opioid-maintained individuals. These studies aim to identify compounds that may be safe and effective adjuncts during opioid detoxification and, potentially, anti-relapse agents. Evidence is also reviewed concerning individual differences identified in these models. Implications of these findings for clinical treatment are also discussed.

Free Delivery
Pinterest Twitter Facebook Google+
You may like...
Walking
Henry David Thoreau Hardcover R699 Discovery Miles 6 990
22 Walks Around Glen Nevis & Fort…
Brian Gordon Smailes Paperback R102 R93 Discovery Miles 930
The Politics Of Custom - Chiefship…
John L. Comaroff, Jean Comaroff Paperback R420 R388 Discovery Miles 3 880
Travels with a Donkey in the Cevennes
Robert Louis Stevenson Hardcover R712 Discovery Miles 7 120
Trail of Tears - An Enthralling Guide to…
Billy Wellman Hardcover R632 R570 Discovery Miles 5 700
Walk It Off - A South African on the…
Erns Grundling Paperback R380 R356 Discovery Miles 3 560
Indian Horrors, or, Massacres by the Red…
Henry Davenport 1836-1909 Northrop Hardcover R1,183 Discovery Miles 11 830
Native Peoples A to Z (Volume Five) - A…
Donald Ricky Hardcover R3,047 Discovery Miles 30 470
Taos Pueblo & Its Sacred Blue Lake
Marcia Keegan Hardcover R707 R599 Discovery Miles 5 990
Sport and Adventures Among the…
Charles Alston B 1841 Messiter Hardcover R1,038 Discovery Miles 10 380

 

Partners