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The basic science of the cellular and molecular responses of the
brain to injury is a rapidly expanding area of research that
provides evidence of growing opportunities for pharmacological
intervention in the clinic. CNS Injuries: Cellular Responses and
Pharmacological Strategies is an up-to-date examination of new
developments in our understanding of the cellular and trophic
responses to CNS injuries and the potential treatment. This text
collates reviews of the most important areas of study regarding
injury response including
inflammatory and immune reactions
scarring
neuron death
demyelination and remyelination
axonal regeneration
re-establishment of neuronal connectivity
Providing a record of recent advances that will help point the way
to future developments, this enlightening reference is sure to
benefit researchers and practitioners in a broad range of
disciplines, including: neurology, pharmacology, pathology,
toxicology, immunology, and many others.
This book is based on the NATO Advanced Research Workshop on
"Mesenchymal-Epithelial Interactions in Neural Development" which
was held in Berlin during March 1986. The idea that it may be the
time for this workshop arose from a discussion among the organizers
who met at a conference in Innsbruck. During the twenties, Spemann
demonstrated that, in vertebrates, the formation of neuroepithelium
depends on the induction by specific mesodermal derivatives. This
was about the first time that mesenchymal-epithelial interactions
had been recognized as an important mechanism in the development of
an epithelial organ. Since then two things had become clear: 1) The
identity and role of molecules, elaborated at
mesenchymal-neuroepithelial interfaces had been partially
elucidated in spinal cord and peripheral nerve ontogeny but, until
recently, had been ignored in studies on the development of the
brain. 2) In many-non-neural epithelia, the surrounding mesenchyme
regulates such fundamental developmental steps as, for example,
cell proliferation, morphogenesis and cell differentia tion, and
there is no reason to exclude similar influences and interactions
from brain development. It seemed to us that the importance and
implications of many of these findings had not been appreciated by
many developmental neurobiologists and that an attempt should be
made to initiate discussions and exchange of ideas among different
groups of scientists involved in extracellular matrix (ECM)
research. This turned out to be a formidable task because of the
great diversity of disciplines contributing findings to this active
field."
Melina and her friend Lisa cannot understand why they have
developed magical powers - until they are whisked away from their
homes in the middle of the night by the Gamlyns, a race of small,
green people from another world and another time. The Gamlyns
derive special powers from an extraordinary sapphire crystal hidden
deep inside a cave. It seems that one of their race has learned to
use its powers for her own wicked purposes, and her quest for power
is threatening both the Gamlyns' world and our own. Melina and Lisa
learn that they have a vital - and dangerous - part to play in
helping the Gamlyns to save both worlds from destruction. An
enthralling, magical fantasy story for 9-12 year olds.
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