The story of a life. The story of the summer. 'Lessons shows [McEwan] at the very peak of his powers. He has written his masterpiece' Daily Telegraph When the world is still counting the cost of the Second World War and the Iron Curtain has descended, young Roland Baines's life is turned upside down. Stranded at boarding school, his vulnerability attracts his piano teacher, Miriam Cornell, leaving scars as well as a memory of love that will never fade. Twenty-five years later Roland's wife mysteriously vanishes, and he is left alone with their baby son. Her disappearance sparks of journey of discovery that will continue for decades, as Roland confronts the reality of his rootless existence and attempts to embrace the uncertainty - and freedom - of his future. 'Ian McEwan is a masterful storyteller' Elif Shafak 'A beautiful book about love, loss and regret' Observer 'Luminous, beautifully written... about lives imperfectly lived' Vogue 'A whole, unruly life between the covers of a single book: a literary feat' Spectator 'A tour de force... A single life is silhouetted against global happenings' Sunday Times * A Book of the Year for The Times, Sunday Times, Financial Times, Spectator, New Statesman, Washington Post, Vogue and New Yorker *

There are two kinds of people in this world. Those who insist that football is just a game, and those who know better. Take the April 1967 clash between England and Scotland.  Wounded by their biggest rivals winning the World Cup just nine months earlier, Bobby Brown's Scots travelled to Wembley on the mother of all missions. Win and they would take a huge step towards qualifying for the 1968 European Championship, end England’s formidable 19-game unbeaten streak, and, best of all, put Sir Alf Ramsey’s men firmly back in their box.  Lose? Well, that was just unthinkable.   Meanwhile, off the pitch, the winds of change were billowing through Scotland. Nationalism, long confined to the margins of British politics, was starting to penetrate the mainstream, gaining both traction and influence. Was England’s World Cup victory a defining moment in the Scottish independence movement? Or did it consign Scotland to successive generations of myopic underachievement?  Michael McEwan, author of The Ghosts of Cathkin Park, returns to 1967 to explore a crucial ninety minutes in the rebirth of a nation. 

Britain has lost the Falklands war, Margaret Thatcher battles Tony Benn for power and Alan Turing achieves a breakthrough in artificial intelligence. In a world not quite like this one, two lovers will be tested beyond their understanding. Machines Like Me occurs in an alternative 1980s London. Charlie, drifting through life and dodging full-time employment, is in love with Miranda, a bright student who lives with a terrible secret. When Charlie comes into money, he buys Adam, one of the first batch of synthetic humans. With Miranda's assistance, he co-designs Adam's personality. This near-perfect human is beautiful, strong and clever - a love triangle soon forms. These three beings will confront a profound moral dilemma. Ian McEwan's subversive and entertaining new novel poses fundamental questions: what makes us human? Our outward deeds or our inner lives? Could a machine understand the human heart? This provocative and thrilling tale warns of the power to invent things beyond our control.

A tree and its impact on the inhabitants of a nearby cottage and manor house over the last century or so is the theme of this compelling tale. We enter a world where humans and spirits mingle with sometimes surprising results. The setting is the remote but beautiful wilds of the Yorkshire moors. You will come to understand the harshness of the winters and the tragedy the cottage and manor house has seen through the years; the pain and anguish of the residents is firmly lodged in the walls of thee buildings. What sights they have seen, what memories they hold, what a fertile breeding ground for the host of spirits and souls that burst from the pages of this surprising and original story. We discover a host of beings, and have the opportunity to enter the lives of a multitude of compelling characters as we journey from a time when living was usually simple and unsophisticated into the end of the last century where the focus of all our lives changed dramatically.

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This updated edition features a new introduction, and an exclusive interview with long-distance runner Paula Radcliffe. It is the world's most iconic road race. It is twenty-six-point-two miles of iconic landmarks, cheers, tears, sweat, pain, courage, determination and inspiration. It is triumph over adversity on a colossal scale. It is the London Marathon - and it's an event unlike any other. Running The Smoke tells the story of what it's like to take part in this race in the most enlightening and enriching way possible: from the perspectives of twenty-six different people who have participated in it since its inception in 1981. Candid and inspiring if you are preparing for your first marathon or your 100th, Running The Smoke will give you the encouragement, insight and belief you need to cross that line.

Nothing stays buried foreverLifeboat volunteer DI Shona Oliver receives a Mayday call coming from Kilcatrin Island. Upon the beach is the badly burned body of a man, and a boy lies gravely injured nearby. Strewn around them are scores of Second World War incendiary bombs, presumably washed up by the tide from Beaufort's Dyke, an offshore arms dump deep in the Irish Sea. The dead man is a local fisherman - his son the other victim - and it rocks the tight-knit community on the shores of the Solway Firth. As lead detective, Shona has to maintain a professional distance. But she can't ignore the hardship that her neighbours who make a living at sea are experiencing. Anger is directed at the Ministry of Defence when the fallout threatens tourism, and livelihoods including Shona's own family B&B business are at risk. Suspicious behaviour seems to be found at every turn. It's impossible for Shona to get to the truth unless she can gain the trust of those who know more than they've been willing to reveal. But blind loyalty may mean she's too late to save those still in danger - including herself. The second instalment in an exciting new Scottish crime series featuring a detective with nerves of steel. Perfect for fans of Neil Lancaster, G. R. Halliday and Ann Cleeves. Praise for Dead Man Deep 'A real cracker of a book. Combining police procedural with the perils of volunteer lifeboat crew and some dodgy MOD arms dumping thrown in for good measure...' Reader Review 'I absolutely loved this book. So much so I read it in one sitting. The twists kept the pages turning and left me shocked at the end. I definitely recommend this series to all crime fiction fans!' Reader Review 'Fun page turner, this one will have you pining for the Scottish coast!' Reader Review 'A very well-written and likeable character... this had the makings of a cracking series.' Reader Review 'Shona Oliver is flawed but hard working and always with good intentions. Lynne McEwan has created a captivating character and I hope more books follow!' Reader Review 'Excellent storyline and characters, so what more do you need? The next title can't come quickly enough.' Reader Review 'A riveting Scottish police procedural.' Reader Review

Nyla Ali Khan's subject, Akbar Jehan, was a political activist and the wife of Sheikh Mohammad Abdullah, Kashmiri nationalist and first Muslim Prime Minister of the disputed state of Jammu and Kashmir. The author employs oral testimonies and relies on written resources to add layers of understanding to the events that shaped the history of Kashmir. In this hybrid of memoir and auto/ biography, the author has also interspersed her memories with descriptions of historical and political events in which Akbar Jehan and her husband were principal political players.

This practical collection examines methodologies originating from the benefits of genome-wide approaches to studying epigenetics, which has opened the emerging field of epigenomics. Focusing on the areas of cancer, inflammatory and autoimmune disorders, chapters discuss three main components of the epigenome and their role in the regulation of gene expression and present a detailed method section specific to studying each component, including data analyses, troubleshooting, and feasibility in different experimental settings. The main topics are high-throughput and targeted methods for DNA methylation analysis, nucleosome position mapping, studying epigenetic effects of gut microbiota, optical imaging for detection of epigenetic aberrations in living cells, methods for microRNA, and histone code profiling. Written for the Methods in Pharmacology and Toxicology series, the book includes the kind of detail and implementation advice to encourage success in the lab. Authoritative and easily applicable, Epigenetics and Gene Expression in Cancer, Inflammatory and Immune Diseases aims to provide pharmacologists, molecular biologists, bioinformaticians, and toxicologists with a vital background on epigenetics and state-of-the-art techniques in epigenomics.

For both teachers and the public, school discipline and classroom management are acute problems in contemporary schools, often taking precedence over issues of curriculum and pedagogy. Yet, surprisingly, discipline and management have escaped sustained critical analysis. This book is a unique, heuristic effort to break the silence regarding modes of classroom control, explicitly bringing democratic, moral, and political perspectives to bear on the issues. It analyzes classroom relationships in terms of ethical and political considerations, arguing that current behaviorist and "teacher-tricks" approaches to classroom control fundamentally contradict expectations of moral development and democratic ends.

Classroom Discipline in American Schools rekindles a debate that has atrophied in the last several decades. It invites teachers and scholars in many fields to examine the moral stances and politics that are enacted daily through the implicit curriculum of mainstream modes of control, and to create new frameworks more consonant with the aspirations and ideals of democratic life.

This book offers a detailed examination of the living arrangements and material circumstances of the poor betweeen 1650 and 1850. Chapters investigate poor households in urban, rural and metropolitan contexts, and contribute to wider investigations into British economic and social conditions in the long Eighteenth century.

Nuclear Receptors focuses on the structural analysis of nuclear receptors from the initial work using isolated protein domains to the more recent exciting developments investigating the conformational shape of full-length receptor complexes. The book also reviews the structure of key nuclear receptor co-regulatory proteins. It brings together, for the first time, a comprehensive review of nuclear receptor structure and the importance of receptor conformation underpinning allosteric regulation by different ligands (hormone, drugs, DNA response elements, protein-protein interactions) and receptor activity. The nuclear receptor superfamily, including receptors for steroid hormones and non-steroid ligands, are pivotal to normal physiology, regulating processes as diverse as reproduction, metabolism, the immune system and brain development. The first members of the family were cloned over 25 years ago, which heralded in the idea of a superfamily of intracellular receptor proteins that bound small molecule ligands: classical steroid hormones, vitamins, fatty acids and other products of metabolism. These signals are then transmitted through multiprotein receptor-DNA complexes, leading to the regulation of target genes, often in a cell-selective manner. The cloning of the receptor cDNAs also ushered in an era of unparalleled analysis of the mechanisms of action of these ligand-activated transcription factors.