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This book is based on the papers presented at the conference on
"Mecha nisms of DNA Damage and Repair: Implications for
Carcinogenesis and Risk Assessment," held at the National Bureau of
Standards on June 2-7, 1985, This volume deals with mechanisms of
DNA damage and repair at the molecular level; consequences of
unrepaired or misrepaired damage, with major emphasis on
carcinogenesis; drugs which bind selectively to altered and
potentially damaging DNA sequences; and potential utilization of
DNA damage as an endpoint for assessing risks of UV light, ionizing
radiations, chemicals, drugs, and hazardous agents in foods.
Because the induction of mutations by radiation and genotoxic
chemicals has been observed to follow one-hit kinetics in some
instances, it is generally assumed that any level of exposure to a
DNA-damaging agent may increase the risk of genetic disease or
cancer in an exposed population. At the same time, however, there
is evidence that although the DNA of living cells is continually
damaged by natural background radiation, free radicals, and other
naturally occurring processes, most of the damage is normally
repaired.
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