This book presents regenerative strategies for the treatment of knee joint disabilities. The book is composed of four main sections totaling 19 chapters which review the current knowledge on the clinical management and preclinical regenerative strategies. It examines the role of different natural-based biomaterials as scaffolds and implants for addressing different tissue lesions in the knee joint. Section one provides an updated and comprehensive discussion on articular cartilage tissue regeneration. Section two focuses on the important contributions for bone and osteochondral tissue engineering. Section three overview the recent advances on meniscus repair/regeneration strategies. Finally, section four further discusses the current strategies for treatment of ligament lesions. Each chapter is prepared by world know expert on their fields, so we do firmly believe that the proposed book will be a reference in the area of biomaterials for regenerative medicine.

This book covers the most recent developments in the field of osteochondral tissue engineering (OCTE) and covers in detail the concepts and current challenges for bone and cartilage repair and regeneration. Specific topics include viscosupplementation, biologicals, tissue engineering approaches, in vitro and in vivo models, and technological advances with stem cells, bioreactors, and microfluidics. Osteochondral Tissue Engineering: Challenges, Current Strategies, and Technological Advances presents challenges and strategies in the field of osteochondral regeneration and serves as a core reference for biomedical engineering students and a wide range of established researchers and professionals working in orthopedics.

This book focuses on the emerging additive manufacturing technology and its applications beyond state-of-the-art, fibre-reinforced thermoplastics. It also discusses the development of a hybrid, integrated process that combines additive and subtractive operations in a single-step platform, allowing CAD-to-Part production with freeform shapes using long or continuous fibre-reinforced thermoplastics. The book covers the entire value chain of this next-generation technology, from part design and materials composition to transformation stages, product evaluation, and end-of-life studies. Moreover, it addresses the following engineering issues: * Design rules for hybrid additive manufacturing; * Thermoplastic compounds for high-temperature and -strength applications; * Advanced extrusion heads and process concepts; * Hybridisation strategies; * Software ecosystems for hAM design, pre-processing, process planning, emulating and multi-axis processing; * 3D path generators for hAM based on a multi-objective optimisation algorithm that matches the recent curved adaptive slicing method with a new transversal scheme; * hAM parameters, real-time monitoring and closed-loop control; * Multiparametric nondestructive testing (NDT) tools customised for FRTP AM parts; * Sustainable manufacturing processes validated by advanced LCA/LCC models.

This book reviews the most recent developments in the field of osteochondral tissue engineering (OCTE) and presents challenges and strategies being developed that face not only bone and cartilage regeneration, but also establish osteochondral interface formation in order to translate it into a clinical setting. Topics include nanotechnology approaches and biomaterials advances in osteochondral engineering, advanced processing methodology, as well as scaffolding and surface engineering strategies in OCTE. Hydrogel systems for osteochondral applications are also detailed thoroughly. Osteochondral Tissue Engineering: Nanotechnology, Scaffolding-Related Developments and Translation is an ideal book for biomedical engineering students and a wide range of established researchers and professionals working in the orthopedic field.

This book focuses on the emerging additive manufacturing technology and its applications beyond state-of-the-art, fibre-reinforced thermoplastics. It also discusses the development of a hybrid, integrated process that combines additive and subtractive operations in a single-step platform, allowing CAD-to-Part production with freeform shapes using long or continuous fibre-reinforced thermoplastics. The book covers the entire value chain of this next-generation technology, from part design and materials composition to transformation stages, product evaluation, and end-of-life studies. Moreover, it addresses the following engineering issues: * Design rules for hybrid additive manufacturing; * Thermoplastic compounds for high-temperature and -strength applications; * Advanced extrusion heads and process concepts; * Hybridisation strategies; * Software ecosystems for hAM design, pre-processing, process planning, emulating and multi-axis processing; * 3D path generators for hAM based on a multi-objective optimisation algorithm that matches the recent curved adaptive slicing method with a new transversal scheme; * hAM parameters, real-time monitoring and closed-loop control; * Multiparametric nondestructive testing (NDT) tools customised for FRTP AM parts; * Sustainable manufacturing processes validated by advanced LCA/LCC models.

This book reviews the most recent developments in the field of osteochondral tissue engineering (OCTE) and presents challenges and strategies being developed that face not only bone and cartilage regeneration, but also establish osteochondral interface formation in order to translate it into a clinical setting. Topics include nanotechnology approaches and biomaterials advances in osteochondral engineering, advanced processing methodology, as well as scaffolding and surface engineering strategies in OCTE. Hydrogel systems for osteochondral applications are also detailed thoroughly. Osteochondral Tissue Engineering: Nanotechnology, Scaffolding-Related Developments and Translation is an ideal book for biomedical engineering students and a wide range of established researchers and professionals working in the orthopedic field.

This book covers the most recent developments in the field of osteochondral tissue engineering (OCTE) and covers in detail the concepts and current challenges for bone and cartilage repair and regeneration. Specific topics include viscosupplementation, biologicals, tissue engineering approaches, in vitro and in vivo models, and technological advances with stem cells, bioreactors, and microfluidics. Osteochondral Tissue Engineering: Challenges, Current Strategies, and Technological Advances presents challenges and strategies in the field of osteochondral regeneration and serves as a core reference for biomedical engineering students and a wide range of established researchers and professionals working in orthopedics.

This book presents regenerative strategies for the treatment of knee joint disabilities. The book is composed of four main sections totaling 19 chapters which review the current knowledge on the clinical management and preclinical regenerative strategies. It examines the role of different natural-based biomaterials as scaffolds and implants for addressing different tissue lesions in the knee joint. Section one provides an updated and comprehensive discussion on articular cartilage tissue regeneration. Section two focuses on the important contributions for bone and osteochondral tissue engineering. Section three overview the recent advances on meniscus repair/regeneration strategies. Finally, section four further discusses the current strategies for treatment of ligament lesions. Each chapter is prepared by world know expert on their fields, so we do firmly believe that the proposed book will be a reference in the area of biomaterials for regenerative medicine.

Multiscale Cell-Biomaterials Interplay in Musculoskeletal Tissue Engineering and Regenerative Medicine addresses the key concepts involved in the interactions between cells and biomaterials in the musculoskeletal tissue engineering and regenerative medicine field. The updated developments and challenges of the mechanisms/mechanobiology and structure-function properties of those interactions, as well as emerging technologies underlying tissue-engineered scaffolding, are carefully discussed. Lastly, cell engineering and cell-based therapies, growth factors/drugs properties, vascularization, immunomodulation are also outlined. Given the large number of musculoskeletal disorders and related injuries that can affect muscles, bones and joints and lead to severe complications of the neuromuscular system, it is imperative to develop new treatment strategies to delay or repair associated diseases and to promote optimal long-term health.

Hydrogels for Tissue Engineering and Regenerative Medicine: From Fundaments to Applications provides the reader with a comprehensive, concise and thoroughly up-to-date resource on the different types of hydrogels in tissue engineering and regenerative medicine. The book is divided into three main sections that describe biological activities and the structural and physicochemical properties of hydrogels, along with a wide range of applications, including their combination with emerging technologies. Written by a diverse range of international academics for professionals, researchers, undergraduate and graduate students, this groundbreaking publication fills a gap in literature needed in the tissue engineering and regenerative medicine field.

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This book offers a comprehensive overview of current knowledge on the health problems and injuries associated with football and their clinical management. After an opening section on technical aspects and fundamental principles, all areas of football traumatology are addressed. The coverage includes muscle, tendon, and stress injuries of the lower limbs and injuries to the ankle and foot, knee, hip and groin, spine and head, and upper limbs. An individual section is also devoted to the most significant heart and other health conditions that may be encountered in players of all ages and standards. Follow-up, rehabilitation, and return to activity are discussed, and the role of performance enhancement strategies is carefully examined, with description of nutritional guidelines and the evidence on use of dietary supplements. A concluding section highlights the potential of the next generation of biologics to improve the regeneration and biofunctionality of damaged tissues. This book is written by world-renowned experts and has been produced in cooperation with ISAKOS. It will serve as a reference in the field of orthopaedics.