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For over thirty years the benzodiazepines monopolised not only the
anxiolytic market but also clinical and animal research in anxiety.
Indeed many animal tests developed since the 1960s have been
optimised for the benzodiazepines and some programmes have even
screened candidates as potential anxiolytics on their
benzodiazepine-like side-effects rather than their anxiolytic
activity. With the realisation of the drawbacks of the
benzodiazepines, namely their potential for tolerance and
dependency, there has been a renewed interest in alternative
anxiolytics both from existing drugs such as the tricyclic and
monoamine oxidase antidepressants and from newer agents such as
buspirone. In addition anxiety is no longer considered to be a
unique entity but rather an umbrella term for a series of specific
anxiety disorders such as panic disorder without or with
agoraphobia, generalised anxiety disorder (GAD), specific phobias,
social phobias and post-traumatic stress disorder (PTSD). These new
clinical categories have opened another dimension in the therapy of
anxiety requiring the optimisation of treatments for different
syndromes. This book is a critical review of today's anxiolytics
and those that may become the anxiolytics of tomorrow. What is
clear is that currently there are few clinically satisfactory
alternatives to the benzodiazepines for the treatment of acute
anxiety. For chronic anxiety, it is generally agreed that benzodi
azepines are not the treatment of first choice. The tricyclic and
monoamine oxidase antidepressants, the serotonin reuptake
inhibitors and buspirone offer better solutions for chronic anxiety
but they are still far from being ideal."
For over thirty years the benzodiazepines monopolised not only the
anxiolytic market but also clinical and animal research in anxiety.
Indeed many animal tests developed since the 1960s have been
optimised for the benzodiazepines and some programmes have even
screened candidates as potential anxiolytics on their
benzodiazepine-like side-effects rather than their anxiolytic
activity. With the realisation of the drawbacks of the
benzodiazepines, namely their potential for tolerance and
dependency, there has been a renewed interest in alternative
anxiolytics both from existing drugs such as the tricyclic and
monoamine oxidase antidepressants and from newer agents such as
buspirone. In addition anxiety is no longer considered to be a
unique entity but rather an umbrella term for a series of specific
anxiety disorders such as panic disorder without or with
agoraphobia, generalised anxiety disorder (GAD), specific phobias,
social phobias and post-traumatic stress disorder (PTSD). These new
clinical categories have opened another dimension in the therapy of
anxiety requiring the optimisation of treatments for different
syndromes. This book is a critical review of today's anxiolytics
and those that may become the anxiolytics of tomorrow. What is
clear is that currently there are few clinically satisfactory
alternatives to the benzodiazepines for the treatment of acute
anxiety. For chronic anxiety, it is generally agreed that benzodi
azepines are not the treatment of first choice. The tricyclic and
monoamine oxidase antidepressants, the serotonin reuptake
inhibitors and buspirone offer better solutions for chronic anxiety
but they are still far from being ideal."
The young Englishman, Peter Bennett, came to visit this beautiful
and peaceful valley deep in Southern France to forget the
infidelity of his ex-fiance with his ex-best friend. Getting lost
and accidentally discovering a strange well with possible
connections to the Cathars and their treasure, being enrolled by an
ex-pat Brit into a dubious property swindle and a whirlwind romance
with a gorgeous older woman certainly take his mind off his amorous
deception in the UK. These events and his naive enthusiasm,
however, entangle him in a deadly international intrigue where no
one is quite who they originally appeared to be. An ordinary person
in an extraordinary situation, can Peter find within himself the
resources he needs to survive and to find a way out of this tangle?
This is a revised version of the story originally published in 2008
under the title 'The Well'.
Four university students get the loan of a sailing boat for a
cruise on the Darkwater River on the East coast of England. The
innocent nautical pleasures of these debutant sailors are harshly
interrupted by brutal events that not only terminate their cruise
but pursue them afterwards as a menace to their futures and
possibly to their lives. With the help of an unexpected ally, they
finally decide to act in a radical way. Did they have any other
choice? Could they have behaved differently? These questions are
likely to haunt them for the rest of their lives.
When Peter Bennett is made redundant from his publishing company in
the UK he decides he needs a break before starting on a new phase
of his career. Influenced by his mother's life-long love of France
he decides to accept a long-standing invitation to visit friends in
South-West France or "Deepest France" as he likes to call it. But
from the moment he sets foot on French soil nothing goes to plan
and Peter rapidly finds himself involved in a series of intrigues
as the fast-paced plot twists and turns like the deep mountain
valley where the action takes place.
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