An integrated approach to elucidate the complex taxonomic history of genus Rheum across the globe. An emblem for traditional utility of Rhubarb across cultures for spectrum of simple to complex human ailments. A rich source of findings and insights on phytochemicals reported till date with their potential use as therapeutic agents. Elucidates different genetic, cytological and biotechnological interventions employed to understand its adaptability, acclimatization, and stability under tremendous natural and anthropogenic pressure. Integration of information available, presented in a single lucid script easily accessible to students, researchers and interested citizens across the globe.