The book contains selected research papers presented at the 2nd International Conference on Cyber-Physical Systems and Control (CPS&C'2021) which was held from 29 June to 2 July 2021 in St. Petersburg, Russia. The CPS&C'2021 Conference continues the series of international conferences that began in 2019 when the first International Conference on Cyber-Physical Systems and Control (CPS&C'2019) took place. Cyber-physical systems (CPSs) considered a modern and rapidly emerging generation of systems with integrated wide computational, information processing, and physical capabilities that can interact with humans through many new modalities and application areas of implementation. The book covers the latest advances, developments and achievements in new theories, algorithms, models, and applications of prospective problems associated with CPSs with an emphasis on control theory and related areas. The multidisciplinary fundamental scientific and engineering principles that underpin the integration of cyber and physical elements across all application areas are discussed in the book chapters. The materials of the book may be of interest to scientists and engineers working in the field of cyber-physical systems, systems analysis, control systems, computer technologies, and similar fields.