This updated and revised Second Edition provides a state-of-the-science review and clinical collection of research on treating depression with multiple therapies. The text is an essential guide for those who prescribe psychotropics or perform psychotherapy, including psychiatrists, residents, psychologists, and psychopharmacologists. Containing research data, case studies, and expert recommendations, this source explores the best acute, long-term, and combination treatment strategies for superior patient care.

New to the Second Edition

• a chapter devoted to a simultaneous discussion on psychotherapy and pharmacotherapy
• chapters on depression and anxiety, depression and pain, and new treatment options
• information on the advancements of genetics, imaging, and brain stimulation with regard to depressive disorders and implications for future use
• the latest research on drug development and combining drug treatments

Non-motor Parkinson's Disease is a burgeoning area of the movement disorders field, as patients increasingly live longer and encounter more late-stage symptoms. The spectrum of non-motor manifestations spans much of the body, with non-motor features occurring in all stages of the disease. Identification of symptoms is key for preserving quality of life and successful treatment. This is a practical manual on all aspects of pre-motor and non-motor manifestations of Parkinson's. The genetic causes of non-motor symptoms are detailed and methods of patient evaluation summarized. Topics such as autonomic and sexual dysfunction, mood disorders, and drug-induced symptoms of non-motor Parkinson's are covered in depth. This is an essential resource for movement disorder specialists, neurologists and other clinicians involved in caring for those with Parkinson's disease.

A large number of neurological conditions result in abnormal movements of the body; these are often characterized by changes in coordination and altered speed of voluntary movement. Many obscure diseases, conditions and environmental insults can cause movement disorders but these are often overlooked. This volume expands and differentiates the many varied clinical presentations of movement disorders. Written by an international team of authors, including some of the most prominent clinicians in the field, disorders are defined and expanded in a clinically useful manner. Pathophysiological theories, genetic discoveries, new classifications, differential diagnoses and therapies are discussed extensively. Uncommon Causes of Movement Disorders provides a broad and comprehensive review of the field, concentrating on conditions infrequently seen but essential for practitioners to recognize in order to implement appropriate management. This is a key text for movement disorders specialists and general neurologists at all stages of their career.

Parkinson's disease is no longer considered only a motor disorder. It has become evident that the pathological changes are broad, the progression seems to follow a pattern suggesting transynaptic transmission via templation of proteins in a prion-like fashion, and that these pathological changes usually antedate the motor symptoms by decades. This book emphasizes treatment options for Parkinson's disease, critically assessing pharmacologic and surgical interventions for all aspects of the disease. Evidence from randomized controlled clinical trials is highlighted to develop practical recommendations for clinical practice. Lessons learnt from clinical trials - and controversies and future challenges - are all addressed. Readers will find the necessary clinical and scientific foundations for the understanding of the disease, the underpinnings of the pathological processes, the identification of disease biomarkers, and the basis for solid therapeutics. Chapters are authored by an international team of specialists who bring their expertise to improving the management of this disease.