It is November 6, 1920, in Chilean Patagonia when Oriana Josseau is born into a lively family with two grandparents, two parents, and sixteen young aunts and uncles, most within easy reach of her robust cries. And so begins the life of an independent-minded girl from the bottom of the world who somehow manages to overcome the restrictions and biases of a conservative patriarchal society and eventually becomes a scientist.

As her family relocates to the idyllic countryside of central Chile and then to the hectic complex society of Santiago, Oriana vividly recalls her reactions to such diverse events as the birth of her brothers; the abrupt transition from wealth to near poverty; her first earthquake; the turmoil of student politics; the challenges of mountain adventures; the exploration of friendship, love and sex; and her first encounter with raw anti-female bias in a male-dominated research world. As she details her life from early childhood on, it soon becomes evident that Oriana must prevail over frequent conflicts with prejudice in order to become a strong, free woman long before the advent of the feminist movement.

Oriana describes beautifully, with humor and empathy, the idiosyncrasies, strengths, and foibles of one woman, and those around her, as she embarks on a unique coming-of-age journey in a different society and different time.

Over the last decade the world has experienced a growing interest in problems associated with the nonmedical use of drugs. This interest has corresponded to a real growth in the extent, diversity, and social impact of the use of alcohol and drugs in many societies. As a result, the amount of research and writing on the subject of drug problems has greatly increased, and it has become very difficult for one individual to keep up with all the relevant literature. There is thus an acute need in the field for critical reviews that assess current developments, and the present series is intended to fill this need. The series is not to be an "annual review" in the usual sense. The aim is not to cover all the work reported during the preceding year in relation to a fixed selection of topics. Rather, it is to present each year evaluative papers on topics in which enough recent progress has been made to alter the general scope in a particular area. Owing to the multidisciplinary nature of problems of drug use and dependence, the papers published in each volume will be drawn from several disciplines. However, some volumes may be devoted to one partic ular problem, with individual reviews and papers examining various aspects of it. The composition of the editorial board and the international advisory board reflects these objectives. The editors are members of the senior scientific staff of the Addiction Research Foundation of Ontario."

It is November 6, 1920, in Chilean Patagonia when Oriana Josseau is born into a lively family with two grandparents, two parents, and sixteen young aunts and uncles, most within easy reach of her robust cries. And so begins the life of an independent-minded girl from the bottom of the world who somehow manages to overcome the restrictions and biases of a conservative patriarchal society and eventually becomes a scientist.

As her family relocates to the idyllic countryside of central Chile and then to the hectic complex society of Santiago, Oriana vividly recalls her reactions to such diverse events as the birth of her brothers; the abrupt transition from wealth to near poverty; her first earthquake; the turmoil of student politics; the challenges of mountain adventures; the exploration of friendship, love and sex; and her first encounter with raw anti-female bias in a male-dominated research world. As she details her life from early childhood on, it soon becomes evident that Oriana must prevail over frequent conflicts with prejudice in order to become a strong, free woman long before the advent of the feminist movement.

Oriana describes beautifully, with humor and empathy, the idiosyncrasies, strengths, and foibles of one woman, and those around her, as she embarks on a unique coming-of-age journey in a different society and different time.