Treatment Landscape of Targeted Therapies in Oncology: Challenges and Opportunities provides up-to-date knowledge on antitumor-targeted therapies and immunotherapy. The book's chapters are written by researchers dynamically working/focusing on cancer treatment. The content is designed to help those who are new to the field (beginners) and various specialized scientists and researchers involved in cancer research. For decades, the hallmark of cancer treatment has been conventional chemotherapy. But with the rapid increase in our understanding of the immune system, more and more small molecules, peptides, recombinant antibodies, vaccines and cellular therapeutic modalities are being applied to manipulate the immune response for cancer treatment.

This book details cutting edge technologies in micromanufacturing processes, an industry which has undergone a technological transformation in the past decade. Enabling engineers to create high performance, low cost and long-lasting products, this book is an essential companion to all those working in micro and nano engineering. As products continue to get smaller and smaller, the field of micromanufacturing has gained an international audience. This book looks at both approaches of micromanufacturing: top-down and bottom-up. The top-down approach includes subtractive micromanufacturing processes such as microturning, micromilling, microdrillling, laser beam micromachining and magnetic abrasive finishing. The bottom-up approach involves additive manufacturing processes such as microforming, micro deep drawing, microforging, microextrusion, and microwelding. Additionally, microjoining and microhybrid manufacturing processes are discussed in detail. The book also aids engineers and students in solving common manufacturing issues such as choice of materials and testing. The book will be of interest to those working in micro and nano engineering and machining, as well as students in manufacturing engineering, materials science and more.

The book titled "Applications of Computational Intelligence Techniques in Communications" is a one-stop platform for the researchers, academicians, and people from industry to get a thorough understanding of the latest research in the field of communication engineering. Over the past decade, a manyfold increase in the use of computational intelligence techniques has been identified for obtaining the most optimal and timely solution to a problem. The various aspects covering the significant contribution of numerous computational intelligence techniques have been discussed in detail in this book. Today’s era of machine learning and Internet of Things (IoT) is demanding as high as possible data rate which has resulted into tremendous increased speed of communication. To match-up the pace, the computational intelligence is posing to be the most efficient and favourite tool. The book aims to cover the current technological advancements in the field of communication engineering and give a detailed prospect of computational intelligence to its readers. This book will be a great support to the people working in the field of IoT, machine learning, healthcare, optimization, filter design, 5G and beyond, signal processing etc. The chapters included here will expose its audience to various newly introduced and advanced computational intelligence techniques applicable in communication domain. The readers will be exposed multiple interdisciplinary areas of research in communication and will get the motivation to work in collaboration with other professionals from both the academia and industry.

The Internet of Energy (IoE), with the integration of advanced information and communication technologies (ICT), has led to a transformation of traditional networks to smart systems. Internet of Energy Handbook provides updated knowledge in the field of energy management with an Internet of Things (IoT) perspective. Features Explains the technological developments for energy management leading to a reduction in energy consumption through topics like smart energy systems, smart sensors, communication, techniques, and utilization Includes dedicated sections covering varied aspects related to renewable sources of energy, power distribution, and generation Incorporates energy efficiency, optimization, and sensor technologies Covers multidisciplinary aspects in computational intelligence and IoT Discusses building energy management aspects including temperature, humidity, the number of persons involved, and light intensity This handbook is aimed at graduate students, researchers, and professionals interested in power systems, IoT, smart grids, electrical engineering, and transmission.

The Internet of Energy (IoE), with the integration of advanced information and communication technologies (ICT), has led to a transformation of traditional networks to smart systems. Internet of Energy Handbook provides updated knowledge in the field of energy management with an Internet of Things (IoT) perspective. Features Explains the technological developments for energy management leading to a reduction in energy consumption through topics like smart energy systems, smart sensors, communication, techniques, and utilization Includes dedicated sections covering varied aspects related to renewable sources of energy, power distribution, and generation Incorporates energy efficiency, optimization, and sensor technologies Covers multidisciplinary aspects in computational intelligence and IoT Discusses building energy management aspects including temperature, humidity, the number of persons involved, and light intensity This handbook is aimed at graduate students, researchers, and professionals interested in power systems, IoT, smart grids, electrical engineering, and transmission.

PGPR Amelioration in Sustainable Agriculture: Food Security and Environmental Management explores the growth-promoting rhizobacteria (PGPR) that are indigenous to soil and plant rhizosphere. These microorganisms have significant potential as important tools for sustainable agriculture. PGPR enhance the growth of root systems and often control certain plant pathogens. As PGPR amelioration is a fascinating subject, is multidisciplinary in nature, and concerns scientists involved in plant heath and plant protection, this book is an ideal resource that emphasizes the current trends of, and probable future of, PGPR developments. Chapters incorporate both theoretical and practical aspects and may serve as baseline information for future research. This book will be useful to students, teachers and researchers, both in universities and research institutes, especially working in areas of agricultural microbiology, plant pathology and agronomy.

Stem Cells: An Alternative Therapy for COVID-19 and Cytokine Storm provides mechanistic insights into the role of stem cells to combat COVID-19 outbreak and other pathologies where cytokines storm is the cause of concern for e.g., radiation exposure, multiple organ failure and sepsis. There has been an increase in number of cases of new diseases in the last decade, including mucormycosis, Zika virus, H1N1 influenza virus, among others. These diseases can be characterized by the induction of cytokine storm, which is mainly responsible for morbidity and mortality. Stem cell therapy has emerged as a potential treatment for viral diseases, including, but not limited to, COVID-19. Interestingly, clinical trials in patients with COVID-19 complications depicted faster recovery in patients post mesenchymal stem cells therapy owing to the decreased cytokines levels, anti-viral effects and regeneration of the infected tissue.

The applications of biocomposite materials are increasing in aerospace, automobile, and household items due to their biodegradable, renewable, non-corrosion, and high strength to weight ratio properties. The processing and characterization of biofiber-reinforced biocomposite materials are vital for their strength and performance. This book discusses the properties, chemical treatment, and compatibility of biofibers with materials.

This book presents the selected peer-reviewed proceedings of the International Conference on Innovative Engineering Design (ICOIED 2020). The contents provide a multidisciplinary approach for the development of innovative product design and their benefits for the society. The book presents latest advances in various fields like design process, service development, micro/nano technology, sensors and MEMS, and sustainability in engineering design. This book can be useful for students, researchers, and professionals interested in innovative product/process design and development.

This book presents the selected peer-reviewed proceedings of the International Conference on Innovative Engineering Design (ICOIED 2020). The contents provide a multidisciplinary approach for the development of innovative product design and their benefits for the society. The book presents latest advances in various fields like design process, service development, micro/nano technology, sensors and MEMS, and sustainability in engineering design. This book can be useful for students, researchers, and professionals interested in innovative product/process design and development.

This book comprises selected proceedings of the International Conference on Recent Advancements in Civil Engineering and Infrastructural Developments (ICRACEID 2019). The contents are broadly divided into five areas (i) smart transportation with urban planning, (ii) clean energy and environment, (iii) water distribution and waste management, (iv) smart materials and structures, and (v) disaster management. The book aims to provide solutions to global challenges using innovative and emerging technologies covering various fields of civil engineering. The major topics covered include urban planning, transportation, water distribution, waste management, disaster management, environmental pollution and control, environmental impact assessment, application of GIS and remote sensing, and structural analysis and design. Given the range of topics discussed, the book will be beneficial for students, researchers as well industry professionals.

This book provides in-depth reviews of the role of Rhizobium in agriculture and its biotechnological applications. Individual chapters explore topics such as: the occurrence and distribution of Rhizobium; phenotypic and molecular characteristics of Rhizobium; impact of Rhizobium on other microbial communities in the rhizosphere; N2-fixation ability of Rhizobium; Rhizobium and biotic stress; Rhizobium-mediated restoration of an ecosystem; in silico analysis of the rhizobia pool; further biotechnological perspectives of Rhizobium.

Oxides for Medical Applications reviews the most important advances of oxides with optical, magnetic and electronic properties for biomedical applications. Owing to their unusual properties, oxides are expected to play a significant role in the prevention or early treatment of diseases. In addition to catalytically active artificial enzymes based on oxide materials-the book provides comprehensive coverage of the most relevant categories of oxide materials and their properties and applications. Since magnetic oxides are used extensively for a wide range of medical applications, there are numerous chapters that address these materials, including LSMO nanoparticles, ferrites, nanocatalysts, and more. Finally, practical considerations for the translation of these materials from the lab to the clinic are reviewed, including biocompatibility and toxicity of oxide nanoparticles, making this a suitable resource for researchers and practitioners in materials science and engineering in academia and the clinic.

Nanobioanalytical Approaches to Medical Diagnostics reviews a range of nanobiomaterials and bioanalytical nano-devices for medical diagnostics. Nanobiomaterials and nano-devices are used in various bioanalytical and biochemical systems to provide real-time, point-of-care diagnostics. The specialized properties of nanoparticles allow them to be engineered and adapted to produce the required effect within a bioanalytical or biochemical system - offering targeted and detailed diagnostic results in a range of biomedical applications. This book covers both traditional biochemical and modern, combined nano-approaches to medical diagnostics. Chapters detail a range of in vitro, in vivo and ex vivo models for nanobioanalytics, including DNA and peptide-based, erythrocyte, microfluidic and more. In addition, sections also look at various different medical diagnostic applications, such as in cancer detection, infectious disease diagnosis and blood glucose sensing.

Novel Therapeutic Approaches Targeting Oxidative Stress investigates the role of oxidative stress in disease and explores the latest methods and approaches to targeting oxidative stress for treatment and diagnosis. The book begins with an introduction to oxidative stress and its significance. Subsequent sections cover biochemical methods for detecting free radicals and novel therapeutic approaches for targeting oxidative stress in a number of different diseases. This includes age-related illnesses, neuropsychiatric disorders such as schizophrenia and bipolar disorder, and neurodegenerative diseases like Alzheimer's and Parkinson's disease. Novel approaches for targeting oxidative stress in cancer and cardiovascular diseases are also explored. The book then moves on to discuss advances in drug delivery systems and detecting oxidative stress biomarkers using biosensors. It concludes with case studies that illustrate the targeting of oxidative stress and future perspectives.

Cardiovascular Toxicity and Therapeutic Modalities Targeting Cardio-Oncology: From Basic Research to Advanced Study analyzes the emerging the field of cardio-oncology, reviewing recent advancements in the field, discussing how to monitor and treat cancer survivors for cardiotoxicity, and identifying potential cardiac side effects in novel cancer therapies. By adopting a translational approach, the book first comprehensively covers the basic science, mechanisms and concepts, which is followed by advanced state-of-art of cardio-oncology. Other sections cover tyrosine kinase inhibitors, Anthracyclines, and biomarkers in cardiotoxicity induced by chemotherapeutic drugs, noninvasive cardiovascular imaging techniques, radiotherapy induced cardiovascular, and more. Anti-cancer treatment is associated with serious cardiovascular adverse events, including arterial and pulmonary hypertension, supraventricular and ventricular arrhythmias, systolic and diastolic cardiac dysfunction and coronary artery disease. Progress in cancer therapy over the past decades improved long-term survival but increased cancer therapy-related cardiotoxicity. Both traditional chemotherapeutic agents and newer therapies have demonstrated profound cardiovascular toxicities. It is important to understand the mechanisms of these toxicities to establish strategies for the prevention and management of complications-arrhythmias, heart failure, and even death.

Joining Processes for Dissimilar and Advanced Materials describes how to overcome the many challenges involved in the joining of similar and dissimilar materials resulting from factors including different thermal coefficients and melting points. Traditional joining processes are ineffective with many newly developed materials. The ever-increasing industrial demands for production efficiency and high-performance materials are also pushing this technology forward. The resulting emergence of advanced micro- and nanoscale material joining technologies, have provided many solutions to these challenges. Drawing on the latest research, this book describes primary and secondary processes for the joining of advanced materials such as metals and alloys, intermetallics, ceramics, glasses, polymers, superalloys, electronic materials and composites in similar and dissimilar combinations. It also covers details of joint design, quality assurance, economics and service life of the product.

This book presents a detailed overview and critical evaluation of recent advances and remaining challenges in improving nutritional quality and/or avoiding the accumulation of undesirable substances in plants using a variety of strategies based on modern biological tools and techniques. Each review chapter provides an authoritative and insightful account of the various aspects of nutritional enhancement of plants. In the course of the last two decades, several food crops rich in macro- and micronutrients have been developed to improve health and protect a large section of the populace in developing countries from chronic diseases. Providing extensive information on these developments, this book offers a valuable resource for all researchers, students and industrialists working in agriculture, the plant sciences, agronomy, horticulture, biotechnology, food and nutrition, and the soil and environmental sciences.

Nanotechnology in Modern Animal Biotechnology: Concepts and Applications discusses the advancement of nanotechnologies in almost every field, ranging from materials science, to food, forensic, agriculture and life sciences, including biotechnology and medicine. Nanotechnology is already being harnessed to address many of the key problems in animal biotechnology, with future applications covering animal biotechnology (e.g. animal nutrition, health, disease diagnosis, and drug delivery). This book provides the tools, ideas and techniques of nanoscale principles to investigate, understand and transform biological systems. Nanotechnology provides the ability to manipulate materials at atomic and molecular levels and also arrange atom-by-atom on a scale of ~1-100 nm to create, new materials and devices with fundamentally new functions and properties arising due to their small scale.

The book introduces the basic concepts of nanotechnology and the various technologies to characterize nanomaterials. It also covers the nanostructural features of mammalian cells/tissues and related nanomechanical properties. In addition, the book comprehensively describes the current state-of-the-art and future perspectives of nanotechnology in biosensors. It also discusses the potential of nanotechnology for delivering the diverse cancer therapeutics and illustrates its limitation due to the potential toxicity associated with oxidative stress. It also highlights the ethical issues and translational aspects related to nanotechnology. Finally, it summarizes the applications of nanotechnology in animal biotechnology, the recent perspectives and future challenges of nanomedicines. The content of the book are beneficial for the undergraduate, postgraduate and doctoral students as well the professionals working in the area of nanotechnology and nanomedicines.

The main aim of this book is to introduce and give an overview of a novel, easy, and highly effective heat transfer augmentation technique for single-phase micro/minichannel heat sink. The specific objectives of the volume are to: Introduce a novel planar oblique fin microchannel and cylindrical oblique fin minichannel heat sink design using passive heat transfer enhancement techniques Investigate the thermal transport in both planar and cylindrical oblique fin structures through numerical simulation and systematic experimental studies. Evaluate the feasibility of employing the proposed solution in cooling non-uniform heat fluxes and hotspot suppression Conduct the similarity analysis and parametric study to obtain empirical correlations to evaluate the total heat transfer rate of the oblique fin heat sink Investigate the flow mechanism and optimize the dimensions of cylindrical oblique fin heat sink Investigate the influence of edge effect on flow and temperature uniformity in these oblique fin channels.

It seems that when businesses were finally understanding, implementing, and getting used to industry 4.0, the term 5.0 came about. Industry 5.0 takes human touch, innovation, and efficiency a step further in creating a turnaround strategy for corporate governance. This transformation has brought many questions to the minds of stakeholders such as when and why this happened. In order to explore the answers to these questions, further study is required to understand the prospects and challenges. Opportunities and Challenges of Business 5.0 in Emerging Markets discusses the present state and future outlooks of Business 5.0 and aims to achieve comprehensive insights on the implications of Business 5.0 in the emerging markets. The book also provides insights to marketers, entrepreneurs, and practitioners to unravel the opportunities and mitigate the challenges in the competitive world. Covering key topics such as big data, e-commerce, and value creation, this reference work is ideal for policymakers, business owners, managers, industry professionals, researchers, scholars, practitioners, academicians, instructors, and students.

It seems that when businesses were finally understanding, implementing, and getting used to industry 4.0, the term 5.0 came about. Industry 5.0 takes human touch, innovation, and efficiency a step further in creating a turnaround strategy for corporate governance. This transformation has brought many questions to the minds of stakeholders such as when and why this happened. In order to explore the answers to these questions, further study is required to understand the prospects and challenges. Opportunities and Challenges of Business 5.0 in Emerging Markets discusses the present state and future outlooks of Business 5.0 and aims to achieve comprehensive insights on the implications of Business 5.0 in the emerging markets. The book also provides insights to marketers, entrepreneurs, and practitioners to unravel the opportunities and mitigate the challenges in the competitive world. Covering key topics such as big data, e-commerce, and value creation, this reference work is ideal for policymakers, business owners, managers, industry professionals, researchers, scholars, practitioners, academicians, instructors, and students.