This book introduces readers to classical population genetics and the ways in which it can be applied to practical problems, including testing for natural selection, genetic drift, genetic differentiation, population structuring, gene flow and linkage disequilibrium. It provides a comprehensive monograph on the topic, addressing the theory, applications and evolutionary deductions, which are clearly explained using experimental results. It also offers separate chapters on origin, establishment and spread of chromosomal aberrations in populations along with details of culturing, maintaining and using Drosophila ananassae (genetically unique and the most commonly used species along with D. melanogaster) for genetic research. Encompassing topics like genetics, evolution, Drosophila genetics, population genetics, population structuring, natural selection and genetic drift in considerable detail, it provides a valuable resource to undergraduate and postgraduate students, as well as researchers at all level. This book explores some fundamental questions concerning the role of natural selection and genetic drift on the degree of inversion polymorphism. India, with its wide diversity in geo-climatic conditions, provides an excellent platform to conduct such studies. The book showcases sampling records of inversion frequencies in natural Indian populations of D. ananassae that cover more than two decades. It highlights case studies in which sampling data on inversion frequencies was combined with that from earlier surveys, generating a time series that allows the evolutionary dynamics of inversion polymorphism to be explored. Such long time series are rare but nonetheless crucial for studying the evolutionary dynamics of inversion polymorphism. The population-genetic analysis discussed is unprecedented in terms of its temporal (two decades) and spatial (most regions of India covered) scale and investigates the patterns of polymorphic system in D. ananassae to see if there is any temporal divergence. It endeavors to present a holistic picture of inversion polymorphism across the country (India). Chromosomal aberrations, particularly paracentric inversions, are used as a tool for discussing population genetic studies, helping human geneticists, gynecologists and other medical professionals understand why some aberrations are fatal in humans, with affected embryos often not surviving the first trimester of pregnancy, while similar aberrations in Drosophila flies aid in their adaptation to the environmental heterogeneity across the globe.

This book introduces readers to classical population genetics and the ways in which it can be applied to practical problems, including testing for natural selection, genetic drift, genetic differentiation, population structuring, gene flow and linkage disequilibrium. It provides a comprehensive monograph on the topic, addressing the theory, applications and evolutionary deductions, which are clearly explained using experimental results. It also offers separate chapters on origin, establishment and spread of chromosomal aberrations in populations along with details of culturing, maintaining and using Drosophila ananassae (genetically unique and the most commonly used species along with D. melanogaster) for genetic research. Encompassing topics like genetics, evolution, Drosophila genetics, population genetics, population structuring, natural selection and genetic drift in considerable detail, it provides a valuable resource to undergraduate and postgraduate students, as well as researchers at all level. This book explores some fundamental questions concerning the role of natural selection and genetic drift on the degree of inversion polymorphism. India, with its wide diversity in geo-climatic conditions, provides an excellent platform to conduct such studies. The book showcases sampling records of inversion frequencies in natural Indian populations of D. ananassae that cover more than two decades. It highlights case studies in which sampling data on inversion frequencies was combined with that from earlier surveys, generating a time series that allows the evolutionary dynamics of inversion polymorphism to be explored. Such long time series are rare but nonetheless crucial for studying the evolutionary dynamics of inversion polymorphism. The population-genetic analysis discussed is unprecedented in terms of its temporal (two decades) and spatial (most regions of India covered) scale and investigates the patterns of polymorphic system in D. ananassae to see if there is any temporal divergence. It endeavors to present a holistic picture of inversion polymorphism across the country (India). Chromosomal aberrations, particularly paracentric inversions, are used as a tool for discussing population genetic studies, helping human geneticists, gynecologists and other medical professionals understand why some aberrations are fatal in humans, with affected embryos often not surviving the first trimester of pregnancy, while similar aberrations in Drosophila flies aid in their adaptation to the environmental heterogeneity across the globe.

This proposed book on human evolution will be a comprehensive book covering all uncovered issues relevant to human evolution. This book deals with human evolution in exhaustive detail. Up-to-date literature and work (2013-14) have been incorporated, thus including every possible piece of information relevant to the subject. Chapter 1 deals with the historical overview of the subject citing the pre-Darwinian and Darwinian eras, and also covers the genesis of human evolution with Africa as the cradle of human existence. Chapter 2 describes different species of the genus "omo" and also various theories of human dispersal. Chapter 3 is devoted to the anatomical and morphological modifications in the body plan and their role in evolving and diversifying Hominins from their Great Ape ancestors. Chapter 4 discusses evidence from molecular biology, genetics and fossils to validate Hominin evolution. Additionally, fossil evidence and lack thereof for different body parts is also described. Chapter 5 and 6 are especially devoted to the behavioral, social-cultural and cognitive aspects of human evolution. They also describe in detail the development and organization of social structure, and social systems with a note on their role in evolving humans. Chapter 7 is included to analyze the biggest controversy of modern time related to human evolution: "Ida as a missing-link". It critically examines different literature to arrive at impartial and rational conclusion about the controversy. Wherever necessary, text is supplemented with figures, ray diagrams and appendices. Appendices and bullet points are provided at the end of the book for a quick recap of the complete evolutionary process.

This book is structured into eight chapters, starting from introductory chapters throwing light on basic evolutionary principles to different aspects of chordate evolution. This book is written to accommodate the needs of diverse readers that range from undergraduate and postgraduate students to research scholars. This book spans diverse but related disciplines that range from morphology, anatomy, taxonomy, physiology, evolution and diversity and has updates from the latest in chordate research.

The evolution to multicellular organisms determined the appearance of more sophisticated and specialized systems for the different physiologies like integumentary, respiration, digestion, excretion, circulatory, reproduction, skeletal and the nervous system. In the line of chordate evolution, advent of tetrapods have triggered the events leading to only partial dependence on water for physiological activities. The inconstant environment in which animals lives largely determine and guides the way animal physiology evolves. This directs the anatomical and morphological changes in the organism that translates into varied and diverse physiological process. This book describes the transition of life from aquatic to terrestrial habitat that brings about changes in feeding habit and subsequent anatomical and morphological changes in the digestive tract. Similar transition also guides modifications in urino-genital system due to demands of removing ammonia/urea or uric acid as excretory waste. The author of this book further explores the evolution of tetrapods as one major event in the evolutionary history of chordates in addition to adaptive radiation. This has transformed the locomotion from Fins' to Feet'. Demands of terrestrial life also means metabolism and energy requirements has to be met for which circulatory system was modified to incorporate more chambers and double circulation for warm bloodedness and increased metabolism to meet the energy requirements of life on land. Subsequently, as explored in the book, different organ systems underwent modification in organization to work together the best physiological adaptations to sustain life on earth.

SPR is real-time, label-free measurements of binding kinetics and affinity. This has distinct advantage over radioactive or fluorescent labelling methods, in terms of: 1) ligand-analyte binding kinetics, that can be probed without the costly and time-consuming labeling process that may interfere with molecular binding interactions; 2) binding rates and affinity can be measured directly and 3) low affinity interactions in high protein concentrations for can be characterized with less reagent consumption than other equilibrium measurement techniques; 4) Label-free detection of molecular interactions presents an attractive alternative. This is particularly true for protein targets where labels can compromise protein function. Label-free methods are also desirable because they are typically compatible with real-time detection, enabling the determination of rates of association. The success of SPR biosensors was indicated by the growing number of commercially available instruments. Since Biacore AB (originally Pharmacia Biosensor AB) launched the first commercial SPR biosensor on market in 1990, there have been many more competing SPR instruments including IASys (Affinity Sensors), SPR-670 (Nippon Laser Electronics), IBIS (IBIS Technology BV), TISPR (Texas Instruments), etc.