This volume will address an important emergent area within the field of immunomics: the discovery of antigens and adjuvants within the context of reverse vaccinology. Conventional approaches to vaccine design and development requires pathogens to be cultivated in the laboratory and the immunogenic molecules within them to be identifiable. Conventional vaccinology is no longer universally successful, particularly for recalcitrant pathogens. By using genomic information we can study vaccine development in silico: 'reverse vaccinology', can identify candidate subunits vaccines by identifying antigenic proteins and by using equally rational approaches to identify novel immune response-enhancing adjuvants.

Organometallic chemistry is an interdisciplinary science which continues to grow at a rapid pace. Although there is continued interest in synthetic and structural studies the last decade has seen a growing interest in the potential of organometallic chemistry to provide answers to problems in catalysis synthetic organic chemistry and also in the development of new materials. This Specialist Periodical Report aims to reflect these current interests reviewing progress in theoretical organometallic chemistry, main group chemistry, the lanthanides and all aspects of transition metal chemistry. Specialist Periodical Reports provide systematic and detailed review coverage of progress in the major areas of chemical research. Written by experts in their specialist fields the series creates a unique service for the active research chemist, supplying regular critical in-depth accounts of progress in particular areas of chemistry. For over 80 years the Royal Society of Chemistry and its predecessor, the Chemical Society, have been publishing reports charting developments in chemistry, which originally took the form of Annual Reports. However, by 1967 the whole spectrum of chemistry could no longer be contained within one volume and the series Specialist Periodical Reports was born. The Annual Reports themselves still existed but were divided into two, and subsequently three, volumes covering Inorganic, Organic and Physical Chemistry. For more general coverage of the highlights in chemistry they remain a 'must'. Since that time the SPR series has altered according to the fluctuating degree of activity in various fields of chemistry. Some titles have remained unchanged, while others have altered their emphasis along with their titles; some have been combined under a new name whereas others have had to be discontinued. The current list of Specialist Periodical Reports can be seen on the inside flap of this volume.

Organometallic chemistry is an interdisciplinary science which continues to grow at a rapid pace. Although there is continued interest in synthetic and structural studies the last decade has seen a growing interest in the potential of organometallic chemistry to provide answers to problems in catalysis, synthetic organic chemistry and also in the development of new materials. This Specialist Periodical Report aims to reflect these current interests reviewing progress in theoretical organometallic chemistry, main group chemistry, the lanthanides and all aspects of transition metal chemistry. Volume 29 covers literature published during 1999.

Organometallic chemistry is an interdisciplinary science which continues to grow at a rapid pace. Although there is continued interest in synthetic and structural studies the last decade has seen a growing interest in the potential of organometallic chemistry to provide answers to problems in catalysis synthetic organic chemistry and also in the development of new materials. This Specialist Periodical Report aims to reflect these current interests reviewing progress in theoretical organometallic chemistry, main group chemistry, the lanthanides and all aspects of transition metal chemistry. Specialist Periodical Reports provide systematic and detailed review coverage of progress in the major areas of chemical research. Written by experts in their specialist fields the series creates a unique service for the active research chemist, supplying regular critical in-depth accounts of progress in particular areas of chemistry. For over 80 years the Royal Society of Chemistry and its predecessor, the Chemical Society, have been publishing reports charting developments in chemistry, which originally took the form of Annual Reports. However, by 1967 the whole spectrum of chemistry could no longer be contained within one volume and the series Specialist Periodical Reports was born. The Annual Reports themselves still existed but were divided into two, and subsequently three, volumes covering Inorganic, Organic and Physical Chemistry. For more general coverage of the highlights in chemistry they remain a 'must'. Since that time the SPR series has altered according to the fluctuating degree of activity in various fields of chemistry. Some titles have remained unchanged, while others have altered their emphasis along with their titles; some have been combined under a new name whereas others have had to be discontinued. The current list of Specialist Periodical Reports can be seen on the inside flap of this volume.

This volume both engages the reader and provides a sound foundation for the use of immunoinformatics techniques in immunology and vaccinology. It addresses databases, HLA supertypes, MCH binding, and other properties of immune systems. The book contains chapters written by leaders in the field and provides a firm background for anyone working in immunoinformatics in one easy-to-use, insightful volume.

Migration is at the center of much of the discussion on globalization. Migrants move across borders and thus defy state-centered traditions. Migration is often caused or influenced by aspects of global change: the transformation of the world economy with the expansion of free trade, the modification of the world balance of power and the challenge of global insecurity, the emergence of the global environment as an important political issue, and the redefinition of the role of communities in shaping identities when faced with networks of migrants and diasporas. Forced Migration and Global Processes considers the crossroads of forced migration with three global trends: development, human rights, and security. This expert collection studies these complex interactions and aims to help determine what solutions may alleviate most of the human suffering involved in forced migrations.

Migration is at the center of much of the discussion on globalization. Migrants move across borders and thus defy state-centered traditions. Migration is often caused or influenced by aspects of global change: the transformation of the world economy with the expansion of free trade, the modification of the world balance of power and the challenge of global insecurity, the emergence of the global environment as an important political issue, and the redefinition of the role of communities in shaping identities when faced with networks of migrants and diasporas. Forced Migration and Global Processes considers the crossroads of forced migration with three global trends: development, human rights, and security. This expert collection studies these complex interactions and aims to help determine what solutions may alleviate most of the human suffering involved in forced migrations.

Pharmaceutical research draws on increasingly complex techniques to solve the challenges of drug design. Bringing together a number of the latest informatics techniques, this book looks at modelling and bioinformatic strategies; structural genomics and X-ray crystallography; virtual screening; lead optimisation; ADME profiling and vaccine design. A number of relevant case studies, focussing on techniques that have demonstrated their use, will concentrate on G-protein coupled receptors as potential disease targets. Providing details of state-of-the-art research, Drug Design: Cutting Edge Approaches will be invaluable to all drug discovery scientists, including medicinal and combinatorial chemists, molecular modellers, bio- and chemoinformaticians, and pharmacologists, amongst others. University and pharmaceutical company libraries will also benefit from having a copy on their shelves.

In a world dominated by considerations of material and security threats, Japan provides a fascinating case for why, and under what conditions, a state would choose to adopt international norms and laws that are seemingly in direct conflict with its domestic norms. Approaching compliance from within a constructivist framework, author Petrice R. Flowers analyzes three treaties--addressing refugee policy, women's employment, and the use of land mines--that Japan has adopted. "Refugees, Women, and Weapons" probes how international relations and domestic politics both play a role in constructing state identity, and how state identity in turn influences compliance.
Flowers argues that, although state desire for legitimacy is a key factor in norm adoption, to achieve anything other than a low level of compliance requires strong domestic advocacy. She offers a comprehensive theoretical model that tests the explanatory power of two understudied factors: the strength of nonstate actors and the degree to which international and domestic norms conflict. Flowers evaluates how these factors, typically studied and analyzed individually, interact and affect one another.

This volume will address an important emergent area within the field of immunomics: the discovery of antigens and adjuvants within the context of reverse vaccinology. Conventional approaches to vaccine design and development requires pathogens to be cultivated in the laboratory and the immunogenic molecules within them to be identifiable. Conventional vaccinology is no longer universally successful, particularly for recalcitrant pathogens. By using genomic information we can study vaccine development in silico: 'reverse vaccinology', can identify candidate subunits vaccines by identifying antigenic proteins and by using equally rational approaches to identify novel immune response-enhancing adjuvants.

The fifth International Symposium on Palaeolimnology was held at Ambleside in the English Lake District from August 31 to September 6, 1989. During the 65 papers were presented at seven sessions and 52 posters symposium displayed. Three late afternoon/evening special lectures were given, one of which was a memorial to the late Ed. Deevey, to whom this volume is dedicated. Associated with the symposium were five excursions to various parts of the UK and Ireland, and a visit to the laboratories of the Freshwater Biological Association and Institute of Freshwater Ecology. Conference participants were also invited to a buffet party and visit to the Lake District National Park Centre at Brockhole as the guests of the Park Authority. The local organising committee for the symposium also formed the editorial panel for this volume. They included: Peter Appleby, Rick Battarbee, John Dearing, Roger Flower, Elizabeth Haworth, Frank Oldfield, Paddy O'Sullivan and John Smith. Support for the conference is gratefully acknowledged from the following organisations; The Royal Society Department of the Environment US Army European Research Office Barclays Bank Central Electricity Generating Board Lake District Special Planning Board South Lakeland District Council Charlotte Mason College Molspin Limited The conference is also indebted to the many individuals who provided such effective help in the preparation and smooth running of the programme. J. P. SMITH May 1991 Hydrobiologia 214: 1-7, 1991.

This volume both engages the reader and provides a sound foundation for the use of immunoinformatics techniques in immunology and vaccinology. It addresses databases, HLA supertypes, MCH binding, and other properties of immune systems. The book contains chapters written by leaders in the field and provides a firm background for anyone working in immunoinformatics in one easy-to-use, insightful volume.

A delightful collection of short stories, based on the life and times of Harold J. Baxter, the author's alter-ego. From the days of his youth, to his marriage and career, here are eighteen heartwarming stories of Baxter's friends and family, of his victories and his challenges.

In the last five years public opinion polls have shown an increasing number of U.S. citizens who believe their nation to be heading on the wrong direction. It was during his training in public administration that Martin Flowers began his personal journey to discover where this great experiment in self government had gone wrong. The result of this journey is this book: Null and Void: How Partisan Politics, Big Business and Lobbyists Conspired to Destroy the American Way of Life. The premise behind Null and Void is very simple. In the preamble to the United States Constitution the government is tasked with five duties ..".establish Justice, insure domestic Tranquility, provide for the common Defense, promote the general Welfare and secure the Blessing of Liberty to ourselves and our posterity..." The problem is our government is not following through on any of these five requirements. This failure of government has resulted in politicians, businesses, lobbyists and special interest groups who are exploiting the failures to advance their own agendas. We've seen examples of this first hand with the lobbying activities of the banking industry and the damage that has done to our economy and ultimately the greed and general lack of leadership existing at the highest levels of government.

God has a plan for your life. You have a purpose and you are valuable and important to your Heavenly Father. So many times in life we go through difficult circumstances that cause us to wonder, "Why me?" or "Why am I here?" Well this book is filled with inspirational words that will cause you to wonder no more. It is divided into moods, so regardless of what frame of mind you are in, you can find just the right section for you. No matter what battles you face, you are not alone; with prayer and faith, you can overcome. With each trial and disappointment you can grow and God can develop your character and strengthen your faith. This book serves as a reminder that in the Midst of every Mess is a Message. Trust God with every detail of your life and be prepared to learn from each situation. Never forget, God can do exceedingly abundantly above what you may ask or think; according to the power that worketh in us. Ephesians 3:20

He had always struggled with it: deja vu - that unsettling feeling that something you are experiencing right now has actually happened in every detail some time in your own past. You can't anticipate it; you are minding your own business when suddenly you have a powerful, inexplicable sensation that you remember this moment, or the angle of the sunlight, or the smell of a specific perfume. But in Baxter's case, this troubling experience occurred so often that it happened not only in waking moments, but it also invaded his dreams; nearly every night he had the same dream, and within that dream, while he was sleeping, he experienced deja vu. His was deja reve - I have dreamed this before.

From the older images of a sad, blue-eyed Jesus to the more recent, more violently graphic portrayals of his suffering, Hollywood has trained us to see the savior of the world as just another victim. To be sure, Jesus Christ endured terrible physical abuse and a barbaric death, but the night before it all happened, when he prayed in agony, alone in the garden, he was anticipating a much darker prospect, a terrible moment that according to Luke's Gospel would cause the sun's light to fail. The Hush presents an alternative view, a much larger, more comprehensive look at the familiar story, combining a unique blend of speculation with the biblical record. Passion and humor and friendship are exchanged between Jesus and his disciples, while all around them danger and conflict and unseen posturing mounts. The week wears away, the hours tick down, the trials commence, and the abuse escalates. Evil is unleashed like never before. And then comes the moment when the sun refuses to shine; as the Lord of the universe is nailed to a tree and lifted from the earth, the Hush descends.