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Elements of Synthesis Planning (Paperback, 2009 ed.): R.W. Hoffmann Elements of Synthesis Planning (Paperback, 2009 ed.)
R.W. Hoffmann
R1,767 Discovery Miles 17 670 Ships in 10 - 15 working days

Synthesis is at the core of organic chemistry. In order for compounds to be studied-be it as drugs, materials, or because of their physical properties- they have to be prepared, often in multistep synthetic sequences. Thus, the target compound is at the outset of synthesis planning. Synthesis involves creating the target compound from smaller, readily available building blocks. Immediately, questions arise: From which bui- ing blocks? In which sequence? By which reactions? Nature creates many highly complex "natural products" via reaction cascades, in which an asso- ment of starting compounds present within the cell is transformed by speci c (for each target structure) combinations of modular enzymes in speci c - quences into the target compounds [1, 2]. To mimic this ef ciency is the dream of an ideal synthesis [2]. However, we are at present so far from - alising such a "one-pot" operation that actual synthesis has to be achieved via a sequence of individual discrete steps. Thus, we are left with the task of planning each synthesis individually in an optimal fashion. Synthesis planning must be conducted with regard for certain speci - tions, some of which are due to the structure of the target molecule, and some of which relate to external parameters such as costs, environmental compatibility, or novelty. We will not consider these external aspects in this context. Planning of a synthesis is based on a pool of information regarding chemical reactions that can be executed reliably and in high chemical yield.

Der Boden in Seiner Chemischen Und Biologischen Beschaffenheit (German, Paperback, Softcover Reprint of the Original 1st 1931... Der Boden in Seiner Chemischen Und Biologischen Beschaffenheit (German, Paperback, Softcover Reprint of the Original 1st 1931 ed.)
E. Blanck, G Hager, R.W. Hoffmann, H Lundegardh, K Maiwald, …
R2,321 Discovery Miles 23 210 Ships in 10 - 15 working days

Auch die Herausgabe des vorliegenden siebenten Bandes des Handbuches hat leider darunter zu leiden gehabt, daB zwei Beitrage nicht zur rechten Zeit beschafft werden konnten, so daB in aller Eile Ersatz geschafft werden muBte. Herr Dr. K. MAlwALD-Breslau ubernahm in entgegenkommender Weise den einen Beitrag, den andern muBte der Herausgeber in der noch zur Verfugung stehenden Zeit erledigen. Es sei Herm Dr. MAIWALD auch an dieser Stelle bestens gedankt. Fur die bei den Korrekturen und der Anfertigung des Autoren- wie Sach registers geleistete aufopfernde Mitarbeit spreche ich auch diesmal den Herren Dr. F. GIESECKE und Dr. F. KLANDER sowie Fraulein Dr. E. VON OLDERSHAUSEN und Fraulein M. SCHAFER meinen warmsten Dank aus. Gottingen im Februar 1931. E. BLANCK. Inhaltsverzeichnis. B. Die chemische Beschaffenheit des Bodens. Seite I. Anorganische Bestandteile des Bodens a) Die hauptsachlichsten Bodenkonstituenten, ihre Natur und Fe- stellung. Von Professor Dr. E. BLANCK, Gottingen ........... . b) Die Mineralbestandteile des Bodens und die Methoden ihrer Er kennung. Von Okonomierat Dr. FR. STEINRIEDE, Munster i. \V. (Mit 7 - bildungen) . . . . . . . . . . . . . . . . . . . . . . . . 23 Optische Untersuchung der Bodenminerale . . . . . . . . . 23 Untersuchung im gewohnlichen (nicht polarisierten) Lichte 23 Untersuchung im polarisierten Lichte . . . . . . 28 Einfache chemische Untersuchung der Bodenminerale 33 Erkennung der Bodenminerale. . . . . . . . . . . 36 Gang der Untersuchung . . . . . . . . . . . . 38 c) Die Kolloidbestandteile des Bodens und die Methoden ihrer Er kennung. Von Dr. G. HAGER, Direktor der Landw. Versuchsstation, Bonn."

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