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Membrane Transport Mechanism - 3D Structure and Beyond (Hardcover, 2014): Reinhard Kramer, Christine Ziegler Membrane Transport Mechanism - 3D Structure and Beyond (Hardcover, 2014)
Reinhard Kramer, Christine Ziegler
R5,369 R5,066 Discovery Miles 50 660 Save R303 (6%) Ships in 12 - 19 working days

This book provides a molecular view of membrane transport by means of numerous biochemical and biophysical techniques. The rapidly growing numbers of atomic structures of transporters in different conformations and the constant progress in bioinformatics have recently added deeper insights.The unifying mechanism of energized solute transport across membranes is assumed to consist of the conformational cycling of a carrier protein to provide access to substrate binding sites from either side of a cellular membrane. Due to the central role of active membrane transport there is considerable interest in deciphering the principles of one of the most fundamental processes in nature: the alternating access mechanism.This book brings together particularly significant structure-function studies on a variety of carrier systems from different transporter families: Glutamate symporters, LeuT-like fold transporters, MFS transporters and SMR (RND) exporters, as well as ABC-type importers.The selected examples impressively demonstrate how the combination of functional analysis, crystallography, investigation of dynamics and computational studies has made it possible to create a conclusive picture or more precisely, a molecular movie . Although we are still far from a complete molecular description of the alternating access mechanism, remarkable progress has been made from static snapshots towards membrane transport dynamics."

Molecular Mechanisms Controlling Transmembrane Transport (Hardcover, 2004 ed.): Eckhard Boles, Reinhard Kramer Molecular Mechanisms Controlling Transmembrane Transport (Hardcover, 2004 ed.)
Eckhard Boles, Reinhard Kramer
R5,953 Discovery Miles 59 530 Ships in 10 - 15 working days

All living cells are strictly separated from their surroundings by a membranous lipid bilayer. Into these membranes a variety of transport proteins are embedded that ensure the uptake and secretion of various molecules and ions. In order to respond properly to a changing nutrient supply or demand, as well as to external stress factors, cells must be able to adapt both amount and activity of the corresponding transporters. This book provides readers with state-of-the-art knowledge on the various regulatory mechanisms that control transmembrane transporter expression, activity and their subcellular localisation.

Membrane Transport Mechanism - 3D Structure and Beyond (Paperback, Softcover reprint of the original 1st ed. 2014): Reinhard... Membrane Transport Mechanism - 3D Structure and Beyond (Paperback, Softcover reprint of the original 1st ed. 2014)
Reinhard Kramer, Christine Ziegler
R5,376 Discovery Miles 53 760 Ships in 10 - 15 working days

This book provides a molecular view of membrane transport by means of numerous biochemical and biophysical techniques. The rapidly growing numbers of atomic structures of transporters in different conformations and the constant progress in bioinformatics have recently added deeper insights. The unifying mechanism of energized solute transport across membranes is assumed to consist of the conformational cycling of a carrier protein to provide access to substrate binding sites from either side of a cellular membrane. Due to the central role of active membrane transport there is considerable interest in deciphering the principles of one of the most fundamental processes in nature: the alternating access mechanism. This book brings together particularly significant structure-function studies on a variety of carrier systems from different transporter families: Glutamate symporters, LeuT-like fold transporters, MFS transporters and SMR (RND) exporters, as well as ABC-type importers. The selected examples impressively demonstrate how the combination of functional analysis, crystallography, investigation of dynamics and computational studies has made it possible to create a conclusive picture or more precisely, "a molecular movie". Although we are still far from a complete molecular description of the alternating access mechanism, remarkable progress has been made from static snapshots towards membrane transport dynamics.

Molecular Mechanisms Controlling Transmembrane Transport (Paperback, Softcover reprint of the original 1st ed. 2004): Eckhard... Molecular Mechanisms Controlling Transmembrane Transport (Paperback, Softcover reprint of the original 1st ed. 2004)
Eckhard Boles, Reinhard Kramer
R5,906 Discovery Miles 59 060 Ships in 10 - 15 working days

All living cells are strictly separated from their surroundings by a membranous lipid bilayer. Into these membranes a variety of transport proteins are embedded that ensure the uptake and secretion of various molecules and ions. In order to respond properly to a changing nutrient supply or demand, as well as to external stress factors, cells must be able to adapt both amount and activity of the corresponding transporters. This book provides readers with state-of-the-art knowledge on the various regulatory mechanisms that control transmembrane transporter expression, activity and their subcellular localisation.

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