This book is authored by leading experts who made major discoveries in neuroteratology research focused on modeling human neural developmental disorders. Individual chapters address ADHD (attention-deficit hyperactivity disorder), Lesch-Nyhan disease, psychoses and schizophrenia, autism, and models of Parkinson's Disease and tardive dyskinesia. The effects of perinatal stress and agonist insults on life-long outcomes are addressed, as well as the overall effects of perinatal neurotoxins on development of specific neural phenotypic systems. The book provides a unique compendium on how perinatal insults of various types can produce effects in brain that persist throughout the life span. Researchers can derive insight into experimental approaches in this research field; clinicians can develop insights into the influences of the many noxious and seemingly innocuous substances that might influence brain development in children.

This book explores the molecular mechanisms of iron hemostasis in the brain and discusses the cognitive and behavioral implications of iron deficiency. It presents the effect of iron dysregulation on neurophysiological mechanisms. The book provides an overview of iron metabolism and homeostasis at the cellular level and its regulation at the mRNA translation level. It emphasizes the importance of iron for brain development in fetal and early life in preterm infants. Further, it presents iron metabolism as a therapeutic target for novel pharmacological treatment against neurodevelopmental diseases and neurodegenerative disorders. It discusses the role of iron deficiency in sleep disorders and offers diagnosis and treatment of iron-related CNS diseases. Finally, it relates dysregulated expression of iron-related genes in brain tumors.

Brain disorders (neurodevelopmental, neurodegenerative, and affective disorders) can be investigated, treated, and prevented using person-centered methods. Because researchers have not reached a clear consensus on whether or not personality is stable or changeable, it has been difficult to outline how to use these methods in the care of people with brain disorders. Thus, the first part aims to identify the ways in which brain disorders and personality are linked. The second part explores different person-centered approaches that can be incorporated in a healthcare or education setting to help people with various brain disorders and to promote physical, mental and social health. The third part focuses on challenges and new venues.

This book is authored by leading experts who made major discoveries in neuroteratology research focused on modeling human neural developmental disorders. Individual chapters address ADHD (attention-deficit hyperactivity disorder), Lesch-Nyhan disease, psychoses and schizophrenia, autism, and models of Parkinson's Disease and tardive dyskinesia. The effects of perinatal stress and agonist insults on life-long outcomes are addressed, as well as the overall effects of perinatal neurotoxins on development of specific neural phenotypic systems. The book provides a unique compendium on how perinatal insults of various types can produce effects in brain that persist throughout the life span. Researchers can derive insight into experimental approaches in this research field; clinicians can develop insights into the influences of the many noxious and seemingly innocuous substances that might influence brain development in children.

Book chapters are authored by participants in the International Meeting on Staging Neuropsychiatric Disorders: Implications for Etiopathogenesis and Treatment, held in Mojacar (Almeria) Spain from 14-18 October 2009. Chapters are organized into four sections on themes encompassed by Staging Neuropsychiatric Disorders: Clinical Staging in the Pathophysiology of Psychotic and Affective Disorders, Staging Perspectives in Neurodevelopmental Aspects of Neuropsychiatry, Epigenetics and Biomarkers in the Staging of Neuropsychiatric Disorders, and Staging Neurodegenerative Disorders. This volume should serve as a resource for physicians and neuroscientists alike, highlighting the importance of staging neuropsychiatric disorders and the underlying mechanistic dysfunction, for prevention and treatment strategies at different stages of disease progression. Earlier volumes in the series, published by the Fundacion Cerebro y Mente in Madrid, Spain: Depressive, Anxiety and Drug Abuse Disorders Eds: T. Palomo and T. Archer Schizophrenia, Movement Disorders and Age Related Cognitive Disorders Eds.: T. Palomo, T. Archer and R.J. Beninger Dopamine Disease States Eds.: R.J. Beninger, T. Palomo and T. Archer Interactive Monoaminergic Disorders Eds.: T. Palomo, R.J. Beninger and T. Archer Neurodegenerative Brain Disorders Eds.: T. Palomo, R.J. Beninger and T. Archer Neurodevelopmental Liabilities in Brain Disease States Eds.: R.J. Beninger, T. Palomo, R.M. Kostrzewa and T. Archer Gene-Environment Interplay in Brain Disease States Eds.: T. Palomo, R.J. Beninger, R.M. Kostrzewa and T. Archer Implications of CoMorbidity for Etiology and Treatment of Neuropsychiatric Disorders Eds.: T. Palomo, R.J. Beninger, R.M. Kostrzewa and T. Archer Beyond Neuropsychiatric Diagnostics: Symptoms not Disorders Eds.: T. Palomo, R.J. Beninger, R.M. Kostrzewa and T. Archer

Book chapters are authored by participants in the International Meeting on "Staging Neuropsychiatric Disorders: Implications for Etiopathogenesis and Treatment," held in Mojacar (Almeria) Spain from 14-18 October 2009. Chapters are organized into four sections on themes encompassed by Staging Neuropsychiatric Disorders: 1) Clinical Staging in the Pathophysiology of Psychotic and Affective Disorders, 2) Staging Perspectives in Neurodevelopmental Aspects of Neuropsychiatry, 3) Epigenetics and Biomarkers in the Staging of Neuropsychiatric Disorders, and 4) Staging Neurodegenerative Disorders. This volume should serve as a resource for physicians and neuroscientists alike, highlighting the importance of staging neuropsychiatric disorders and the underlying mechanistic dysfunction, for prevention and treatment strategies at different stages of disease progression."