Mitochondrial Intoxication explores the effects toxic molecules can have upon mitochondrial physiology in the human body. Each chapter is dedicated to a specific toxicant, including pollutants, food additives, illicit and pharmaceutical drugs, and heavy metals. This book considers the implications and impact these have upon mitochondria and the diseases that can result from dysfunction and impairment in the human body. Furthermore, the book provides an overview of mitochondrial physiology and assesses the advances and challenges in testing mitochondrial toxicity. Case studies exploring mitochondrial intoxication in pregnancy and in the geriatric population are also included. This is a comprehensive reference on the main toxicants impacting mitochondria in the human body, and the consequences this can have for health and disease.

When choosing the technology options to develop a wireless sensor network (WSN), it is vital that their performance levels can be assessed for the type of application intended. This book describes the different technology options - MAC protocols, routing protocols, localisation and data fusion techniques - and provides the means to numerically measure their performance, whether by simulation, mathematical models or experimental test beds. Case studies, based on the authors' direct experience of implementing wireless sensor networks, describe the design methodology and the type of measurements used, together with samples of the performance measurements attained.
The book will enable you to answer vital questions such as:
* How long will my network remain alive given the amount of sensing required of it?
* For how long should I set the sleeping state of my motes?
* How many sensors should I distribute to meet the expected requirements of the application?
* What type of throughput should I expect as a function of the number of nodes deployed and the radio interface chosen (whether it be Bluetooth or Zigbee)?
* How is the Packet Error Rate of my Zigbee motes affected by the selection of adjacent frequency sub bands in the ISM 2.4GHz band?
* How is the localisation precision dependant on the number of nodes deployed in a corridor?
Communications and signal processing engineers, researchers and graduate students working in wireless sensor networks will find this book an invaluable practical guide to this important technology.
""This book gives a proper balance between theory and application; it is a book for those R&D engineers that want to appreciate both why, how and in which domains Wireless Sensor Networks can be best applied."" - Fabio Bellifemine, Telecom Italia
""This book is a thorough and accessible exposition on wireless sensor networks with a good balance between theory and practice; it is valuable for both students and practicing engineers, and is an essential addition for engineering libraries."" - Professor Moe Win, Associate Professor at the Laboratory for Information and Decision Systems (LIDS), Massachusetts Institute of Technology
*Only book to examine wireless sensor network technologies and assess their performance capabilities against possible applications
*Enables the engineer to choose the technology that will give the best performance for the intended application
*Case studies, based on the authors' direct experience of implementing wireless sensor networks, describe the design methodology and the type of measurements used, together with samples of the performance measurements attained.

A guide to disrupting harmful mindsets and practices in our schools so that students can thrive where they are.In many schools and districts, students of color living in low-income communities are told in simple and covert ways every day that they must leave their communities if they want to be successful. The message may be well-intentioned, but the leave to succeed (L2S) mindset is a dangerous narrative that affects students' sense of self. Students start to wonder: Are low-income or marginalized communities inherently "bad"? What happens to the people who don't "make it out"? Who is worthy of success? Instead, Nancy GutiÉrrez and Roberto Padilla turn the L2S mindset on its head to interrogate how school and district leaders can nurture and support students to find success in their own communities. They share real-world vignettes, reflection questions, and clear and simple tips to build an asset-based, uplifting approach that honors the backgrounds, cultures, and strengths of Black and Brown communities. You will learn how to * Recognize how the L2S mindset is pervasive in many schools. Encourage students to develop their unique stories of self that highlight their cultural backgrounds. Build schools that are innovative, offer a community-rich curriculum, and are held accountable to provide deep learning to all students. Rewrite the dominant narrative in your school system to become a disruptive yet positive force in education. Embrace the moral responsibility to be an equitable, fair, and compassionate leader to all students, no matter their socioeconomic backgrounds. No one is truly served by deficit-based narratives, and for every student to feel valued and affirmed, schools and districts must embrace the idea that any student in any school can stay in their community and prevail.

This book is an account of a study which provided unique information on trends in growth and respiratory health in British children over 25 years, with methodological discussion and other major findings including risk factors for impaired growth, obesity, respiratory disease and the distribution of coronary heart disease factors. The book provides information on trends in growth, height weight for height and subcutaneous arm tissue, and in respiratory health, asthma attacks and related symptoms, in children aged 5 to 11 years, from 1972 to 1994. It provides information on risk factors for impaired growth, obesity and respiratory disease, and on the distribution of risk factors for coronary heart disease in children. The contribution of the National Health and Growth Study extended to topics such as the effects of changes in welfare policy, under-diagnosis and under-treatment of asthma, nocturnal enuresis, disturbed sleep, the impact of passive smoking on the health of children, and the relation of lung function to the child's intra-uterine environment and to passive smoking. The methodological issues in relation to the conduct of the study and analysis of the data are discussed in non-technical language. Each contribution of the study is discussed in relation to current literature, which is fully referenced throughout.

This comprehensive book explores different methods and approaches to legal comparison, considering how they are perceived and understood by the reader. It examines how comparative discussion can be used effectively in both the classroom and courtroom. The author builds on both analytical and methodological perspectives to provide an insight into the phenomenon of legal pluralism across global legal systems. Chapters introduce a historical perspective to provide readers with the tools for deeper comparative legal research, while also discussing the various methods of comparative law and their usefulness in legal education and research. Roberto Scarciglia outlines a detailed methodological framework for the study of complex global issues, and explores the idea that collaboration between scholars and the growing trend towards interdisciplinarity are necessary to study complex legal problems and avoid superficial comparisons. Providing a well-rounded exploration and navigation of this important topic, this book will be an essential companion for both undergraduate and postgraduate law students. Legal scholars and practitioners will benefit from the nuanced discussion of research on different legal systems.

Through careful investigation into the role of eco-innovation as a catalysing factor in the societal transition towards sustainability, this Handbook proposes more appropriate measures of innovation as a driver of change. It examines innovation from various perspectives, including labour, trade, the circular economy and energy, to illustrate a more comprehensive picture of its impacts. Chapters by leading authors from the sectors of eco-innovation, sustainability transformations and green and circular economies provide a meticulously balanced observation of innovation at local, regional, national and global scales. By featuring case studies from across Australasia, Europe and Latin America, as well as empirical work and modelling exercises, this forward-thinking Handbook links innovation to a range of interconnected topics. It imparts new evidence to offer a succinct conclusion about the potential success of certain innovation and green industrial policies. This enlightening Handbook will be valuable for scholars and academics studying economics and management, economic and social innovation, and environmental policy. It will also be of great benefit for those analysing policy and industry professionals looking to learn more about eco-innovation.

Few would dispute that the United States had been the world's most influential nation since Henry Luce first popularized the notion of an American Century in 1941. The significance of the influence, however, remains a subject of hot debate. This collection brings together international scholars who offer differing views on American international dominance in the past century and the prospects for its continuation into this one. These range from positive assessments of the role of the United States in forging a global community and in operating as a relatively benign global hegemon to a scathing critique of Washington policy makers for failing to reverse the ethically corrosive impact of the Cold War on American diplomatic practice.

American global influence has not been synonymous with omnipotence. The United States is not impervious to external influences and has itself been transformed by the forces of globalization--a phenomenon viewed by some as synonymous with Americanization. These essays highlight the notion that the phrase American Century implies the diffusion internationally of liberal capitalist principles. This book suggests that the role of the United States in diffusing those principles is at the heart of the debate about the significance of American global influence, whether in retrospect or in prospect. Includes the views of Asian, Antipodean, and American Scholars.

As public infrastructure, health and other services are being delivered more frequently through Public-Private Partnerships (PPPs) and concessions, this timely book explores these complex contractual arrangements involving cooperation between public and private sectors. It considers how PPPs have become increasingly prevalent following the 2008 financial crisis and examines the applicable legal regimes that are still, to a large extent, unclear to many. Containing in-depth investigation into EU law and comparative national experiences in relation to PPPs and concessions in 7 EU Member States and the UK, the contributions in this incisive book address the weak points in the current legal regime. Chapters analyse the risks faced by contracting authorities in connection to PPPs and concessions while highlighting good practices from different countries that may be considered for wider adoption across the EU. Public-Private Partnerships and Concessions in the EU will be a key resource for scholars and students of public administrative law and businesses seeking to procure contracts to create PPPs, as well as being of value to practitioners and policy makers at both EU and national levels. Contributors include: P. Bogdanowicz, K. Bonsignore, R. Caranta, P. Cerqueira Gomes, A. Christidis, M.E. Comba, D.C. Dragos, N. Gabayet, C. Kroenke, P. Patrito, C. Risvig Hamer, P. Telles, P. Valcarcel Fernandez, R. Vornicu

This detailed Commentary provides an authoritative interpretation of each provision in the main EU Directive on public procurement - Directive 2014/24/EU, and is rich in its critical analysis of the provisions of the 2014 Directive and the case-law. The Commentary also highlights the application problems and interpretative issues being raised in EU Member States, which in due time will make their way up to the CJEU or even require further legislative interventions. Key features include: Updated to include the most significant CJEU case law as of end-2020 Analysis that is informed by the practical issues arising across the EU Member States, as well as in the UK Written by a diverse pool of specialists in each of the aspects of the Directive upon which they comment, with the Commentary underpinned by their collective knowledge of public procurement law in the old 28 EU Member States. Providing a practice-oriented analysis that allows for a problem solving approach, European Public Procurement will be particularly relevant to practising lawyers including within the civil services in all EU jurisdictions and the UK. The depth of analysis offered in the Commentary will also be of great benefit to academics and postgraduate students with an interest in public procurement and, more generally, public law, administrative law and public administration.

Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

What link might connect two far worlds like quantum theory and music? There is something universal in the mathematical formalism of quantum theory that goes beyond the limits of its traditional physical applications. We are now beginning to understand how some mysterious quantum concepts, like superposition and entanglement, can be used as a semantic resource.

This book provides the first comprehensive appraisal of the paradigm shift towards mandatory sustainability requirements in EU public procurement law. Traditionally, EU public procurement law focused on ‘how to buy’, dictating procedural rules so that public buyers in the Member States did not discriminate against suppliers and service providers from other Member States. Mandatory green and social requirements mean that, with a view to achieving sustainable development goals and mitigating climate change, the EU will limit this discretionary power for public buyers, pushing them to acquire more sustainable goods and services. Based on legal analysis informed by economic perspectives, the book aims to contribute to an understanding and critical discussion of the EU legislator’s move towards regulating ‘what to buy’. The book discusses the role of the Public Procurement Directives in relation to this paradigm shift, as well as various other sectoral legislative instruments that have been revamped or newly introduced in light of the European Green Deal. The paradigm shift is analysed from different perspectives, including subsidiarity, alternative regulation, economics and public purchasing. The book includes novel sectoral studies on transport, food, clothing, and construction, discussing how change is taking place and what its major challenges are for the future. Chapters on Italy, the Netherlands, Spain, and more, offer case studies of Member States that have already introduced mandatory requirements and highlight lessons learnt. This is an essential book for professionals working with public procurement law in academia and practice, and to those engaged in achieving public policy objectives in light of climate change and social injustice.

Functionalized Nanomaterials for Biosensing and Bioelectronics Applications: Trends and Challenges describes current and future opportunities for integrating the unique properties of two-dimensional nanomaterials with bioelectronic interfaces. Sections focus on background information and fundamental concepts, review the available functionalized nanomaterials and their properties, explore the integration of functionalized nanomaterials with bioelectronics, including available fabrication and characterization methods, electrical behavior at the interface, and design and synthesis guidelines, and review examples of microsystems where functionalized nanomaterials are being integrated with bioelectronics. This book is suitable for researchers and practitioners in academia and R&D working in materials science and engineering, analytical chemistry and related fields.

This ground-breaking Handbook presents a state-of-the-art exploration of entropy, complexity, and spatial dynamics from fundamental theoretical, empirical and methodological perspectives. It considers how foundational theories can contribute to new advances, including novel modeling and empirical insights at different sectoral, spatial, and temporal scales. With the help of leading experts worldwide, the Handbook examines how and to what extent entropic and non-entropic forces and processes in complex spatial socio-economic systems shape and are shaped by their structure and dynamics. Moreover, considering current concerns that big data and related data-driven methods may signal an end to theory, this Handbook is intended to investigate the potential and possibilities for complexity science to engage, revitalize, and advance theory in spatial economics. Overall, this Handbook reaches beyond qualitative generalizations, contributing to the identification of fundamental structural and dynamic properties of the complex space-economy. Drawing upon diverse foundations and perspectives, the Handbook on Entropy, Complexity and Spatial Dynamics: A Rebirth of Theory? will be an essential resource for researchers and students of many fields and disciplines, including economics, urban planning and geography, regional science, information science, physics, and biology.

Occupational Neurotoxicology, Volume Seven covers neurotoxicants and exposures to a variety of hazards in the workplace and how they can affect nervous functions in different ways. Metals and organic compounds, both at high level acute exposure and long-term low-level exposure can affect motor functions, cognition, behavior and neurosensory functions. Sections cover Oil leakage in aircraft, aerotoxic syndrome, Organic solvents, WTC neurotoxicities, Environmental intolerance, Pesticides, Carbon monoxide, Mercury Neurotoxicity in Gold Miners, and the Current evolution of neurobehavioral methods.