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Research in the pharmaceutical industry today is in many respects
quite different from what it used to be only fifteen years ago.
There have been dramatic changes in approaches for identifying new
chemical entities with a desired biological activity. While
chemical modification of existing leads was the most important
approach in the 1970s and 1980s, high-throughput screening and
structure-based design are now major players among a multitude of
methods used in drug discov ery. Quite often, companies favor one
of these relatively new approaches over the other, e.g., screening
over rational design, or vice versa, but we believe that an
intelligent and concerted use of several or all methods currently
available to drug discovery will be more successful in the medium
term. What has changed most significantly in the past few years is
the time available for identifying new chemical entities. Because
of the high costs of drug discovery projects, pressure for maximum
success in the shortest possible time is higher than ever. In
addition, the multidisciplinary character of the field is much more
pronounced today than it used to be. As a consequence, researchers
and project managers in the pharmaceutical industry should have a
solid knowledge of the more important methods available to drug
discovery, because it is the rapidly and intelligently combined use
of these which will determine the success or failure of preclinical
projects.
Research in the pharmaceutical industry today is in many respects
quite different from what it used to be only fifteen years ago.
There have been dramatic changes in approaches for identifying new
chemical entities with a desired biological activity. While
chemical modification of existing leads was the most important
approach in the 1970s and 1980s, high-throughput screening and
structure-based design are now major players among a multitude of
methods used in drug discov ery. Quite often, companies favor one
of these relatively new approaches over the other, e.g., screening
over rational design, or vice versa, but we believe that an
intelligent and concerted use of several or all methods currently
available to drug discovery will be more successful in the medium
term. What has changed most significantly in the past few years is
the time available for identifying new chemical entities. Because
of the high costs of drug discovery projects, pressure for maximum
success in the shortest possible time is higher than ever. In
addition, the multidisciplinary character of the field is much more
pronounced today than it used to be. As a consequence, researchers
and project managers in the pharmaceutical industry should have a
solid knowledge of the more important methods available to drug
discovery, because it is the rapidly and intelligently combined use
of these which will determine the success or failure of preclinical
projects.
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