The proceedings of the 5th International Workshop on Parallel Tools for High Performance Computing provide an overview on supportive software tools and environments in the fields of System Management, Parallel Debugging and Performance Analysis. In the pursuit to maintain exponential growth for the performance of high performance computers the HPC community is currently targeting Exascale Systems. The initial planning for Exascale already started when the first Petaflop system was delivered. Many challenges need to be addressed to reach the necessary performance. Scalability, energy efficiency and fault-tolerance need to be increased by orders of magnitude. The goal can only be achieved when advanced hardware is combined with a suitable software stack. In fact, the importance of software is rapidly growing. As a result, many international projects focus on the necessary software.

As more and more hardware platforms support parallelism, parallel programming is gaining momentum. Applications can only leverage the performance of multi-core processors or graphics processing units if they are able to split a problem into smaller ones that can be solved in parallel. The challenges emerging from the development of parallel applications have led to the development of a great number of tools for debugging, performance analysis and other tasks. The proceedings of the 3rd International Workshop on Parallel Tools for High Performance Computing provide a technical overview in order to help engineers, developers and computer scientists decide which tools are best suited to enhancing their current development processes.

This book constitutes the refereed proceedings of the 10th International Workshop on OpenMP, held in Salvador, Brazil, in September 2014. The 16 technical full papers presented were carefully reviewed and selected from 18 submissions. The papers are organized in topical sections on tasking models and their optimization; understanding and verifying correctness of OpenMP programs; OpenMP memory extensions; extensions for tools and locks; experiences with OpenMP device constructs.

This book constitutes the refereed proceedings of the 9th International Workshop on OpenMP, held in Canberra, Australia, in September 2013. The 14 technical full papers presented were carefully reviewed and selected from various submissions. The papers are organized in topical sections on proposed extensions to OpenMP, applications, accelerators, scheduling, and tools.

This book constitutes the refereed proceedings of the 8th International Workshop on OpenMP, held in in Rome, Italy, in June 2012. The 18 technical full papers presented together with 7 posters were carefully reviewed and selected from 30 submissions. The papers are organized in topical sections on proposed extensions to OpenMP, runtime environments, optimization and accelerators, task parallelism, validations and benchmarks

RF Probeheads 1. J. Link, Faellanden, Switzerland The Design of Resonator Probes with Homogeneous Radiofrequency Fields 2. M. Schnall, Philadelphia, PA/USA Probes Tuned to Multiple Frequencies for In-Vivo NMR RF Pulses 3. P.C.M. van Zijl, Rockville, MD/USA; C.T.W. Moonen, Bethesda, MD/USA Solvent Suppression Strategies for In Vivo Magnetic Resonance Spectroscopy 4. M. Garwood, K. Ugurbil, Minneapolis, MN/USA B1 Insensitive Adiabatic RF Pulses 5. P.G. Morris, Nottingham, UK Frequency Selective Excitation Using Phase-Compensated RF Pulses in One andTwo Dimensions 6. S. Mueller, Basel, Switzerland RF Pulses for MultipleFrequency Excitation: Theory and Application Spectrum Analysis 7. R. de Beer, D. van Ormondt, Delft, The Nethelands Analysis of NMR Data Using Time Domain Fitting Procedures 8. E.B. Cady, London, UK Determination of Absolute Concentrations of Metabolites from NMR Spectra

As more and more hardware platforms support parallelism, parallel programming is gaining momentum. Applications can only leverage the performance of multi-core processors or graphics processing units if they are able to split a problem into smaller ones that can be solved in parallel. The challenges emerging from the development of parallel applications have led to the development of a great number of tools for debugging, performance analysis and other tasks. The proceedings of the 3rd International Workshop on Parallel Tools for High Performance Computing provide a technical overview in order to help engineers, developers and computer scientists decide which tools are best suited to enhancing their current development processes.

OpenMP is an application programming interface (API) that is widely accepted as a de facto standard for high-level shared-memory parallel programming. It is a portable, scalable programming model that provides a simple and ?exible interface for developing shared-memory parallel applications in Fortran, C, and C++. Since its introduction in 1997, OpenMP has gained support from the - jority of high-performance compiler and hardware vendors. Under the direction of the OpenMP Architecture Review Board (ARB), the OpenMP speci?cation is undergoing further improvement. Active research in OpenMP compilers, r- time systems, tools, and environments continues to drive OpenMP evolution.To provideaforumforthedisseminationandexchangeofinformationaboutand- periences with OpenMP, the community of OpenMP researchersand developers in academia and industry is organized under cOMPunity (www.compunity.org). This organization has held workshops on OpenMP since 1999. This book contains the proceedings of the 5th International Workshop on OpenMP held in Dresden in June 2009. With sessions on tools, benchmarks, applications, performance and runtime environments it covered all aspects of the current use of OpenMP. In addition, several contributions presented p- posed extensions to OpenMP and evaluated reference implementations of those extensions. An invited talk provided the details on the latest speci?cation dev- opment inside the Architecture Review Board. Together with the two keynotes about OpenMP on hardware accelerators and future generation processors it demonstrated that OpenMP is suitable for future generation systems.

OpenMP is an application programming interface (API) that is widely accepted as a standard for high-level shared-memory parallel programming. It is a portable, scalable programming model that provides a simple and ?exible interface for - veloping shared-memory parallel applications in Fortran, C, and C++. Since its introduction in 1997, OpenMP has gained support from the majority of high-performance compiler and hardware vendors. Under the direction of the OpenMP Architecture Review Board (ARB), the OpenMP standard is being further improved. Active research in OpenMP compilers, runtime systems, tools, and environments continues to drive its evolution. To provide a forum for the d- semination and exchange of information about and experiences with OpenMP, the community of OpenMP researchers and developers in academia and industry is organized under cOMPunity (www. compunity. org). Workshops on OpenMP have taken place at a variety of venues around the world since 1999: the European Workshop on OpenMP (EWOMP), the North American Workshop on OpenMP Applications and Tools (WOMPAT), and the AsianWorkshoponOpenMP Experiences andImplementation (WOMPEI)were each held annually and attracted an audience from both academia and industry. The intended purpose of the new International Workshop on OpenMP (IWOMP) was to consolidate these three OpenMP workshops into a single, yearly inter- tional conference. The ?rst IWOMP meeting was held during June 1-4, 2005, in Eugene, Oregon, USA. The second meeting took place during June 12-15, in Reims, France.

Jurgen Habermas , wrote the American philosopher Ronald Dworkin on the occasion of the great European thinker s eightieth birthday, is not only the world s most famous living philosopher. Even his fame is famous. Now, after many years of intensive research and in-depth conversations with contemporaries, colleagues and Habermas himself, Stefan Muller-Doohm presents the first comprehensive biography of one of the most important public intellectuals of our time. From his political and philosophical awakening in West Germany to the formative relationships with Adorno and Horkheimer, Muller-Doohm masterfully traces the major forces that shaped Habermas s intellectual development. He shows how Habermas s life and work were conditioned by the possibilities offered to his generation in the unique circumstances of regained freedom that characterized postwar Germany. And yet Habermas s career is fascinating precisely because it amounts to more than a corpus of scholarly work, however original and influential that may be. For here is someone who continually left the protective space of the university in order to assume the role of a participant in controversial public debates D from the significance of the Holocaust to the future of Europe D and in this way sought to influence the development of social and political life in an arena much broader than the academy. The significance and virtuosity of Habermas s many writings over the years are also fully and expertly documented, ranging from his early work on the public sphere to his more recent writings on communicative action, cosmopolitanism and the postnational condition. What emerges from this biography is a vivid portrait of one of the great public intellectuals of our time D a unique thinker who has made an immense and lasting philosophical contribution but who, when he perceives that society is not living up to its potential for creating free and just conditions for all, becomes one of its most rigorous and persistent critics.

This book constitutes the proceedings of the 13th International Workshop on OpenMP, IWOMP 2017, held in Stony Brook, NY, USA, in September 2017. The 23 full papers presented in this volume were carefully reviewed and selected from 28 submissions. They were organized in topical sections named: Advanced Implementations and Extensions; OpenMP Application Studies; Analyzing and Extending Tasking; OpenMP 4 Application Evaluation; Extended Parallelism Models: Performance Analysis and Tools; and Advanced Data Management with OpenMP.

This book constitutes the refereed proceedings of the 11th International Workshop on OpenMP, held in Aachen, Germany, in October 2015. The 19 technical full papers presented were carefully reviewed and selected from 22 submissions. The papers are organized in topical sections on applications, accelerator applications, tools, extensions, compiler and runtime, and energy.

'Even the biographical individual is a social category', wrote Adorno. 'It can only be defined in a living context together with others.' In this major new biography, Stefan Muller-Doohm turns this maxim back on Adorno himself and provides a rich and comprehensive account of the life and work of one of the most brilliant minds of the twentieth century.
This authoritative biography ranges across the whole of Adorno's life and career, from his childhood and student years to his years in emigration in the United States and his return to postwar Germany. At the same time, Muller-Doohm examines the full range of Adorno's writings on philosophy, sociology, literary theory, music theory and cultural criticism. Drawing on an array of sources from Adorno's personal correspondence with Horkheimer, Benjamin, Berg, Marcuse, Kracauer and Mann to interviews, notes and both published and unpublished writings, Muller-Doohm situates Adorno's contributions in the context of his times and provides a rich and balanced appraisal of his significance in the 20th Century as a whole.
Muller-Doohm's clear prose succeeds in making accessible some of the most complex areas of Adorno's thought. This outstanding biography will be the standard work on Adorno for years to come.

Written and edited by experts in the field, this book brings together the current state of the art in phenotypic and rational, target-based approaches to drug discovery against pathogenic protozoa. The chapters focus particularly on virtual compounds and high throughput screening, natural products, computer-assisted drug design, structure-based drug design, mechanism of action identification, and pathway modelling. Furthermore, state-of the art "omics" technologies are described and currently studied enzymatic drug targets are discussed. Mathematical, systems biology-based approaches are introduced as new methodologies for dissecting complex aspects of pathogen survival mechanisms and for target identification. In addition, recently developed anti-parasitic agents targeting particular pathways, which serve as lead compounds for further drug development, are presented.

Hier finden Sie den aktuellen Wissensstand der Gastroenterologie didaktisch klar und ubersichtlich zum schnellen Nachschlagen. Inhalt und Gliederung sind auf die Weiterbildungsinhalte abgestimmt. - Symptom-orientierter Aufbau: Motilitats- und funktionelle Stoerungen, entzundliche Erkrankungen, Tumore und Stoffwechselerkrankungen - Pathophysiologische Grundlagen - Klinische Krankheitsbilder, Diagnostik und Therapie - Wichtige Leitsymptome und Notfallsituationen knapp und pragnant auf einen Blick Ein Referenz-Werk, das Ihnen den raschen UEberblick in Klinik und Praxis erleichtert und prazise Detail-Informationen fur Ihre Weiterbildung bietet.

Nach dem bundesweit rasanten Ausbau der Kinderkrippen sind nun mehr denn je hilfreiche Qualifizierungsmassnahmen gefragt. Michaela S. Muller untersucht, welche Fahigkeiten eine qualifizierte Krippenfachkraft ausmachen und wie diese vermittelt werden koennen. Sie befasst sich vor allem mit den personalen Kompetenzen, beleuchtet ihre Bedeutung fur den Entwicklungs- und Bildungsprozess der Kleinkinder und zeigt Ansatze auf, wie diese gefoerdert werden koennen. Oftmals handelt es sich bei personalen Ressourcen um abstrakte Begriffe, wie Empathiefahigkeit, die schwer zu fassen und zu definieren sind. Diesem Problem stellt sich das Projekt "VIA-QiKi", welches in der Praxis erfolgreich erprobt wurde und hier vorgestellt wird. Dabei wird es auf verstandliche Weise moeglich, die Feinfuhligkeit und Responsivitat der Fachkrafte zu schulen und die Interaktionen im Alltag zu erleichtern.

This newest edition to the Laboratory Techniques Series gives current state of the art use of synthetic peptides in molecular biology and practical protocols on how to conjugate peptides, immunize animals with peptides and monitor immune responses to peptides in vitro.
It gives background information on antigenic specificity, prediction of antigenic sites in proteins and applications of peptides in immunology and virology, as probes in diagnosis and as vaccines. The book also describes antigenicity of proteins and methods to localize antigenic sites as well as methods for predicting epitoxes, and gives detailed protocols for peptide-carrier conjugation, immunization with peptides, and peptide immunoassays.
The volume also describes typical use of antipeptide antibodies in molecular and cellular biology as well as the use of peptides in the diagnosis of viral infections and autoimmune diseases, and the use of peptides as potential synthetic vaccines. An excellent edition to an excellent series, available in hardbound and paperback.

This newest edition to the Laboratory Techniques Series gives current state of the art use of synthetic peptides in molecular biology and practical protocols on how to conjugate peptides, immunize animals with peptides and monitor immune responses to peptides in vitro.
It gives background information on antigenic specificity, prediction of antigenic sites in proteins and applications of peptides in immunology and virology, as probes in diagnosis and as vaccines. The book also describes antigenicity of proteins and methods to localize antigenic sites as well as methods for predicting epitoxes, and gives detailed protocols for peptide-carrier conjugation, immunization with peptides, and peptide immunoassays.
The volume also describes typical use of antipeptide antibodies in molecular and cellular biology as well as the use of peptides in the diagnosis of viral infections and autoimmune diseases, and the use of peptides as potential synthetic vaccines. An excellent edition to an excellent series, available in hardbound and paperback.

Dieses Buch soll ein Bericht uber den Prozess Einstein sein. Es enthalt das Material uber die Diskussion um die Relativitatstheorie in der UdSSR seit 1950. Von 1951 bis 1955 wurde Einstein durch die offizielle Parteiphilosophie der UdSSR in den Anklagezustand versetzt. Der Prozess gipfelte in der Aufforderung, die Relativitatstheorie zu verwerfen und durch eine materialistische 'Theorie schneller Bewegungen' zu ersetzen. Selbst der Name 'Relativitatstheorie' sollte aus den physikalischen Lehrbuchern verschwinden. Die Anklage wurde vertreten von der ideologischen Fuhrungsschicht der gewaltigsten irdischen Macht unseres Zeitalters. Der Angeklagte, in der Reife seines Lebens vor die vehementesten Angriffe gestellt, kam nur durch sein Werk zu Wort. Dies genugte jedoch, dass sich unter den sowjetischen Physikern und Philosophen noch zur Zeit Stalins mannhafte Stimmen der Verteidigung fanden. 1955 wurde der Prozess mit der offiziellen Anerkennung der Relativitats theorie durch die Parteiphilosophie abgeschlossen. Es war ein Sieg der Wahrheit uber die Gewalt. Die Folgen mussten das Ansehen der kommunistischen Ideologie erschuttern. Es hatte sich herausgestellt, dass zwischen der angeblich einzig wissenschaftlichen Philosophie und der exaktesten Naturwissen schaft, der Physik, ein Abgrund klafft, den zu uberbrucken die Sowjet philosophie bis heute bemuht ist. Andererseits begannen die sowjetischen Physiker, wachgerufen durch die Appelle der Philosophen, ihr eigenes Weltbild mit adaquaten Methoden zu durchdenken. Diese ganze Ent wicklung ist von hohem Wert fur eine Diagnose der geistigen Struktur der Sowjetgesellschaft."

Die allgemeine Relativitatstheorie ist ein Gebirge, das unahnlich ihrer Vorlauferin, der speziellen Relativitatstheorie, in einigen hintereinander- folgenden Eruptionen fast ausschlieBlich aus dem schOpferischen Denken Einsteins entstand. Wenn die spezielle Relativitatstheorie gewissermaBen die Vorberge darstellt, so die allgemeine eine im Himmel verschwimmende Gruppe erhabener Gipfel. Sie zahlt anerkannterweise zu den am schwer- sten zuganglichen Regionen der Physik. Dennoch blickt auch der Nicht- Fachmann mit Staunen zu ihren Hohen empor, die er zwar nicht zu bezwingen, aber doch aus der Feme zu schauen vermag. Nicht alle ihre Kliifte und Hohen wurden bisher von den "Einheimischen", den Physi- kern, durchwandert. Es gibt Partien, die wohl noch keines Menschen Geist durchschritt, Einstein nicht ausgenommen. Das philosophische Denken hat ihr weit weniger Beachtung geschenkt als der speziellen Re- 1ativitatstheorie. Und doch rufen ihre Prinzipien und Ergebnisse noch dringender nach einer 10gischen Analyse, da ihre Satze von den voraus- gesetzten Beobachtungstatsachen durch eine langere SchluBkette entfernt sind als in jeder anderen physikalischen Theorie zuvor. Wir mlissen daher den sowjetischen Gelehrten dankbar sein, daB sie die phi1osophischen Probleme mutig anpackten. Seit der dramatischen Wende der offiziellen Sowjetphilosophie gegeniiber Einstein 1955 wandten sich die Philosophen und Physiker statt einer un- fruchtbaren Polemik einer echten Durchdenkung der Relativitatstheorie zu. Dabei tritt die allgemeine Relativitatstheorie mehr und mehr in den Vordergrund. Freilich spielt sie noch nicht die dominierende Rolle; dies hangt offenbar mit methodischen Schwierigkeiten zusarnrnen, aber sicher nieht nur damit, wie das Referat eines so hervorragenden Mathernatikers wie A. D.

Die Fibel erklArt in schematischen Aoebersichten mit kurzen ErlAuterungen knapp und verstAndlich die wichtigsten gastrointestinalen Leitsymptome. Der vielbeschAftigte Arzt erhAlt damit eine praxisbezogene, A1/4bersichtliche Information A1/4ber die notwendigen ersten diagnostischen und therapeutischen MaAnahmen.

Die Fibel fasst die Prinzipien, Aussagen und Indikationen der gastroenterologischen Funktionsuntersuchungen in knapper und verstandlicher Form zusammen. Der differentialdiagnostische Einsatz der Funktionsuntersuchungen wird anhand wichtiger gastroenterologischer Leitsymptome aufgezeigt. Das Wesentliche ist den schematischen Ubersichten zu entnehmen, die durch kurze Texte erlautert werden. Der praktisch tatige Arzt erhalt damit rasch einen Uberblick uber den Stellenwert der Funktionsuntersuchungen bei gastroenterologischen Problemen."

Die vorliegende Pankreatitisfibel richtet sich an den in Praxis oder Klinik praktisch tatigen Arzt. In einfacher Form werden die wichtigsten Informationen uber die akute und chronische Pankreatitis vermittelt. Der Schwerpunkt liegt auf den fur das praktische Vorgehen relevanten Aspekten. Die Empfehlungen basieren auf dem neuesten Erkenntnisstand."

Ribozymes Provides comprehensive coverage of a core field in the molecular biosciences, bringing together decades of knowledge from the world's top professionals in the field Timely and unique in its breadth of content, this all-encompassing and authoritative reference on ribozymes documents the great diversity of nucleic acid-based catalysis. It integrates the knowledge gained over the past 35 years in the field and features contributions from virtually every leading expert on the subject. Ribozymes is organized into six major parts. It starts by describing general principles and strategies of nucleic acid catalysis. It then introduces naturally occurring ribozymes and includes the search for new catalytic motifs or novel genomic locations of known motifs. Next, it covers the development and design of engineered ribozymes, before moving on to DNAzymes as a close relative of ribozymes. The next part examines the use of ribozymes for medicinal and environmental diagnostics, as well as for therapeutic tools. It finishes with a look at the tools and methods in ribozyme research, including the techniques and assays for structural and functional characterization of nucleic acid catalysts. The first reference to tie together all aspects of the multi-faceted field of ribozymes Features more than 30 comprehensive chapters in two volumes Covers the chemical principles of RNA catalysis; naturally occurring ribozymes, engineered ribozymes; DNAzymes; ribozymes as tools in diagnostics and therapy, and tools and methods to study ribozymes Includes first-hand accounts of concepts, techniques, and applications by a team of top international experts from leading academic institutions Dedicates half of its content to methods and practical applications, ranging from bioanalytical tools to medical diagnostics to therapeutics Ribozymes is an unmatched resource for all biochemists, biotechnologists, molecular biologists, and bioengineers interested in the topic.