In this issue of Cardiac Electrophysiology Clinics, guest editors Drs. Kenneth A. Ellenbogen, Pugazhendhi Vijayaraman, and Santosh Padala bring their considerable expertise to the topic of Advances in Physiologic Pacing (such as dual-chamber (DDD and DDDR) and atrium-based pacing (AAI and AAIR) in contrast to ventricle-based pacing (VVI and VVIR). Top experts in the field cover key topics such as what we have learned from computer modeling of hemodynamics and LV pacing; troubleshooting the pacemaker EKG in patients with conduction system pacing; what intracardiac tracings have taught us about LBBB; multisite pacing in CRT; and more. Contains 20 relevant, practice-oriented topics including basic principles of hemodynamics during pacing; pacing optimized by dP/dt; optimization of CRT: Q-LV; programming algorithms for CRT; and more. Provides in-depth clinical reviews on physiologic pacing, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.