"Biological resource centers (BRCs) collect, certify, and distribute organisms for use in research and in the development of commercial products in the pharmaceutical, agricultural, and biotechnology industries. They maintain a large and varied collection, including cell lines, micro-organisms, recombinant DNA material, biological media and reagents, and the information technology tools that allow researchers to access biological materials. BRCs have established themselves as a crucial element in the life science innovation infrastructure, from their early impact on virology, to their crucial role in addressing cross-culture contamination in the 1970s, to their current leadership in promoting a global biodiversity network. Today they confront new challenges, resulting from shifts in the nature of biological research, the interaction between public and private researchers, and the increasing focus on biosecurity. This book provides a systematic economic assessment of the impact of biological resource centers through their role in facilitating cumulative knowledge in the life sciences and building on their roles as knowledge hubs-institutions that facilitate the transfer of scientific and technical knowledge among members of a research community. The knowledge hubs framework offers insight into how to develop and evaluate policy proposals that impinge on the control and access of biological materials. Stern argues that science and innovation policy must be premised on a clear understanding of the role that knowledge hubs play and the policy mechanisms that encourage their sustained growth and effectiveness. "

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. An engaging case-based approach to learning the diagnostic process in internal medicine Symptom to Diagnosis, Fourth Edition teaches an evidence-based, step-by-step process for evaluating, diagnosing, and treating patients based on their clinical complaints. By applying this process clinicians will be able to recognize specific diseases and prescribe the most effective therapy. Each chapter is built around a common patient complaint that illustrates essential concepts and provides insight into the process by which the differential diagnosis is identified. Coverage for each disease includes: Textbook Presentation, Disease Highlights, Evidence-Based Diagnosis, and Treatment. *Enhanced by algorithms, summary tables, and questions that direct evaluation*Each chapter is built around patient cases that illustrate essential concepts*Clinical pearls appear in every chapter

The papers in the sixteenth volume of the National Bureau of Economic Research's Innovation Policy and the Economy offer insights into the changing landscape of innovation by highlighting recent developments in the financing of innovation and entrepreneurship and in the economics of innovation and intellectual property. The first chapter, by Ramana Nanda and Matthew Rhodes-Kropf, explores the process of experimentation in the context of financing of technology start-ups by venture capitalists. The second, by Yael Hochberg, also analyzes the role of entrepreneurial experimentation by systematically examining the rise of start-up accelerators. The third chapter, by Heidi Williams, studies the relationship between the strength of intellectual property rights and innovation. The fourth paper, by Fiona Scott Morton and Carl Shapiro discusses recent changes to the patent system and whether they align the rewards from intellectual property with the marginal contributions made by innovators and other stakeholders. The final chapter, by Karim Lakhani and Kevin Boudreau, focuses on the potential use of field innovation experiments and contests to inform innovation policy and management. Together, these essays continue to highlight the importance of economic theory and empirical analysis in innovation policy research.

Technology-based industries have come to account for ever-greater shares of economic activity during the last 30 years. Recently, rapid, digitally-enabled technological change has generated new opportunities for value creation, enabled new ways of capturing value, and stimulated the emergence of new organizational forms such as platforms and ecosystems. Together with the development of supporting institutions, including incubators, accelerators, and increasingly creative ways of funding new ventures, this has led to an explosion of interest in entrepreneurial activity across industries and sectors. Scholars, policymakers and practitioners recognize the importance of technological innovation and entrepreneurship for competitive advantage, comparative advantage, and society's economic well-being. There is tremendous academic and practical interest not only in how new ventures assemble resources necessary to deliver value, but also on how incumbent organizations may adapt to harness technological innovation, and on how industries evolve in the face of this pervasive technological change. Despite recent advances in our understanding of how innovation and entrepreneurship impact the creation and appropriation of value, numerous questions remain unanswered. This volume draws together scholars working at the forefront of entrepreneurship-, strategy-, and innovation-related domains to explore these questions. The volume makes particular contributions to the entrepreneurship, innovation, and platform literatures.

This volume presents studies from experts in twelve industries, providing insights into the future role of innovation and entrepreneurship in driving economic growth across sectors. We live in an era in which innovation and entrepreneurship seem ubiquitous, particularly in regions like Silicon Valley, Boston, and the Research Triangle Park. But many metrics of economic growth, such as productivity growth and business dynamism, have been at best modest in recent years. The resolution of this apparent paradox is dramatic heterogeneity across sectors, with some industries seeing robust innovation and entrepreneurship and others seeing stagnation. By construction, the impact of innovation and entrepreneurship on overall economic performance is the cumulative impact of their effects on individual sectors. Understanding the potential for growth in the aggregate economy depends, therefore, on understanding the sector-by-sector potential for growth. This insight motivates the twelve studies of different sectors that are presented in this volume. Each study identifies specific productivity improvements enabled by innovation and entrepreneurship, for example as a result of new production technologies, increased competition, or new organizational forms. These twelve studies, along with three synthetic chapters, provide new insights on the sectoral patterns and concentration of the contributions of innovation and entrepreneurship to economic growth.