"Notch Signaling: Methods and Protocols" focuses on molecular, biochemical and bioinformatics aspects of Notch signaling. Chapters analyze the Notch interactome, post-translational modifications of Notch, ligand binding assays, methods to assess proteolytic cleavage and transcriptional targets. Written in the highly successful "Methods in Molecular Biology "series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and key tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, " Notch Signaling: Methods and Protocols" is a valuable contribution to hundreds of labs and thousands of scientists who pursue this research area with vigor.

Notch Signaling: Methods and Protocols focuses on molecular, biochemical and bioinformatics aspects of Notch signaling. Chapters analyze the Notch interactome, post-translational modifications of Notch, ligand binding assays, methods to assess proteolytic cleavage and transcriptional targets. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Notch Signaling: Methods and Protocols is a valuable contribution to hundreds of labs and thousands of scientists who pursue this research area with vigor.

The bonobo, along with the chimpanzee, is one of our two closest living relatives. Their relatively narrow geographic range (south of the Congo River in the Democratic Republic of Congo) combined with the history of political instability in the region, has made their scientific study extremely difficult. In contrast, there are dozens of wild and captive sites where research has been conducted for decades with chimpanzees. Because data sets on bonobos have been so hard to obtain and so few large-scale studies have been published, the majority of researchers have treated chimpanzee data as being representative of both species. However, this misconception is now rapidly changing. With relative stability in the DRC for over a decade and a growing community of bonobos living in zoos and sanctuaries internationally, there has been an explosion of scientific interest in the bonobo with dozens of high impact publications focusing on this fascinating species. This research has revealed exactly how unique bonobos are in their brains and behavior, and reminds us why it is so important that we redouble our efforts to protect the few remaining wild populations of this iconic and highly endangered great ape species.

The bonobo, along with the chimpanzee, is one of our two closest living relatives. Their relatively narrow geographic range (south of the Congo River in the Democratic Republic of Congo) combined with the history of political instability in the region, has made their scientific study extremely difficult. In contrast, there are dozens of wild and captive sites where research has been conducted for decades with chimpanzees. Because data sets on bonobos have been so hard to obtain and so few large-scale studies have been published, the majority of researchers have treated chimpanzee data as being representative of both species. However, this misconception is now rapidly changing. With relative stability in the DRC for over a decade and a growing community of bonobos living in zoos and sanctuaries internationally, there has been an explosion of scientific interest in the bonobo with dozens of high impact publications focusing on this fascinating species. This research has revealed exactly how unique bonobos are in their brains and behavior, and reminds us why it is so important that we redouble our efforts to protect the few remaining wild populations of this iconic and highly endangered great ape species.