"Notch Signaling: Methods and Protocols" focuses on molecular, biochemical and bioinformatics aspects of Notch signaling. Chapters analyze the Notch interactome, post-translational modifications of Notch, ligand binding assays, methods to assess proteolytic cleavage and transcriptional targets. Written in the highly successful "Methods in Molecular Biology "series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and key tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, " Notch Signaling: Methods and Protocols" is a valuable contribution to hundreds of labs and thousands of scientists who pursue this research area with vigor.

Notch Signaling: Methods and Protocols focuses on molecular, biochemical and bioinformatics aspects of Notch signaling. Chapters analyze the Notch interactome, post-translational modifications of Notch, ligand binding assays, methods to assess proteolytic cleavage and transcriptional targets. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Notch Signaling: Methods and Protocols is a valuable contribution to hundreds of labs and thousands of scientists who pursue this research area with vigor.

This volume includes twelve novel empirical papers focusing on the behaviour and cognition of both captive and wild bonobos (Pan paniscus). As our species less known closest relative, the bonobo has gone from being little studied to increasingly popular as a species of focus over the past decade. Overall this volume demonstrates how anyone interested in understanding humans or chimpanzees must also know bonobos. Bonobos are not only equal to chimpanzees as our relatives, but they are also unique. The majority of papers in this volume show that whether you are interested in the evolution of culture and tool use, social relationships and sharing or foraging ecology and cognition, bonobos have a major contribution to make. Four papers provide further evidence that the behaviour and psychology of bonobo females is radically different from that observed in chimpanzees. Foraging behaviour and cognition of bonobos is the focus of three papers that each show important ways that bonobos spatial cognition differs remarkably from chimpanzees. Two papers are relevant to solving the puzzle of why bonobos are expert extractive foragers in captivity but have never been seen using tools to obtain food in the wild. The articles presented in this volume are previously published in a Special Issue of Behaviour, Volume 152, Parts 3-4 (March 2015).

The bonobo, along with the chimpanzee, is one of our two closest living relatives. Their relatively narrow geographic range (south of the Congo River in the Democratic Republic of Congo) combined with the history of political instability in the region, has made their scientific study extremely difficult. In contrast, there are dozens of wild and captive sites where research has been conducted for decades with chimpanzees. Because data sets on bonobos have been so hard to obtain and so few large-scale studies have been published, the majority of researchers have treated chimpanzee data as being representative of both species. However, this misconception is now rapidly changing. With relative stability in the DRC for over a decade and a growing community of bonobos living in zoos and sanctuaries internationally, there has been an explosion of scientific interest in the bonobo with dozens of high impact publications focusing on this fascinating species. This research has revealed exactly how unique bonobos are in their brains and behavior, and reminds us why it is so important that we redouble our efforts to protect the few remaining wild populations of this iconic and highly endangered great ape species.

The bonobo, along with the chimpanzee, is one of our two closest living relatives. Their relatively narrow geographic range (south of the Congo River in the Democratic Republic of Congo) combined with the history of political instability in the region, has made their scientific study extremely difficult. In contrast, there are dozens of wild and captive sites where research has been conducted for decades with chimpanzees. Because data sets on bonobos have been so hard to obtain and so few large-scale studies have been published, the majority of researchers have treated chimpanzee data as being representative of both species. However, this misconception is now rapidly changing. With relative stability in the DRC for over a decade and a growing community of bonobos living in zoos and sanctuaries internationally, there has been an explosion of scientific interest in the bonobo with dozens of high impact publications focusing on this fascinating species. This research has revealed exactly how unique bonobos are in their brains and behavior, and reminds us why it is so important that we redouble our efforts to protect the few remaining wild populations of this iconic and highly endangered great ape species.