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Key Features * Explores evolutionary context and comparative
physiology of hypoxia tolerance in fetus and neonate, from basic
research to clinical scenarios * Provides guidance to trainees,
physicians and allied health professionals engaged in NICU care;
pediatricians, cardiologists, pulmonologists, anesthesiologists,
neonatologists and physiologists, to effectively manage infants in
hypoxic respiratory failure * Includes case scenarios emphasizing
current diagnostic and therapeutic controversies, and algorithmic
approaches to decipher difficult clinical cases.
Diverse in chemical nature, water soluble and lipid soluble
vitamins are essential micronutrients that react with specific
protein entities and are transported to sites for participation in
intracellular events, both at the genomic and non-genomic levels.
Thus, metabolic pathways and intracellular signaling are influenced
by vitamins or their derivatives through vitamin binding to
specific proteins. Vitamin-Binding Proteins: Functional
Consequences examines the function of various vitamins based on
this binding, as well as their role as antioxidants, leading to
effects on intracellular mechanisms. This book explores the
resulting functional consequences at the level of cells, tissues,
and organs as well as the neurological, endocrine, and immune
systems. The text addresses the effects that lead to both normal
physiological function and pharmacological activity with
significant therapeutic potential in a wide spectrum of disease
processes. Leading experts discuss various vitamins including the
function of retinoids in development, immunity, and obesity; the
role of vitamin D in the immune system, infectious processes, and
cardiovascular disease; and the effects of vitamins E, C, and K on
the vascular system. Chapters cover the therapeutic potential of
the vitamin B6 vitamer pyridoxamine and the lipid-soluble
B1analogue benfotiamine. They also describe various functions of
biotin as well as gene transcriptional regulation through biotin
and biotin-binding proteins. The text addresses folate
receptor-mediated therapeutics, vitamin B12 derivatives in tumor
targeting, and implication of ascorbic acid in different disorders.
Expounding newer areas of vitamin function, this book explores the
interface of physiological vitamin function and pharmacological
vitamin action, offering a broad perspective of possible vitamin
binding therapeutics.
Diverse in chemical nature, water soluble and lipid soluble
vitamins are essential micronutrients that react with specific
protein entities and are transported to sites for participation in
intracellular events, both at the genomic and non-genomic levels.
Thus, metabolic pathways and intracellular signaling are influenced
by vitamins or their derivatives through vitamin binding to
specific proteins. Vitamin-Binding Proteins: Functional
Consequences examines the function of various vitamins based on
this binding, as well as their role as antioxidants, leading to
effects on intracellular mechanisms. This book explores the
resulting functional consequences at the level of cells, tissues,
and organs as well as the neurological, endocrine, and immune
systems. The text addresses the effects that lead to both normal
physiological function and pharmacological activity with
significant therapeutic potential in a wide spectrum of disease
processes. Leading experts discuss various vitamins including the
function of retinoids in development, immunity, and obesity; the
role of vitamin D in the immune system, infectious processes, and
cardiovascular disease; and the effects of vitamins E, C, and K on
the vascular system. Chapters cover the therapeutic potential of
the vitamin B6 vitamer pyridoxamine and the lipid-soluble
B1analogue benfotiamine. They also describe various functions of
biotin as well as gene transcriptional regulation through biotin
and biotin-binding proteins. The text addresses folate
receptor-mediated therapeutics, vitamin B12 derivatives in tumor
targeting, and implication of ascorbic acid in different disorders.
Expounding newer areas of vitamin function, this book explores the
interface of physiological vitamin function and pharmacological
vitamin action, offering a broad perspective of possible vitamin
binding therapeutics.
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