This book constitutes the refereed proceedings of the Third MICCAI Workshop on Distributed, Collaborative, and Federated Learning, DeCaF 2022, and the Second MICCAI Workshop on Affordable AI and Healthcare, FAIR 2022, held in conjunction with MICCAI 2022, in Singapore in September 2022. FAIR 2022 was held as a hybrid event.DeCaF 2022 accepted 14 papers from the 18 submissions received. The workshop aims at creating a scientific discussion focusing on the comparison, evaluation, and discussion of methodological advancement and practical ideas about machine learning applied to problems where data cannot be stored in centralized databases or where information privacy is a priority. For FAIR 2022, 4 papers from 9 submissions were accepted for publication. The topics of the accepted submissions focus on deep ultrasound segmentation, portable OCT image quality enhancement, self-attention deep networks and knowledge distillation in low-regime setting.