Hospitals, medical practices and healthcare organizations are implementing new technologies at breakneck speed. Yet privacy and security considerations are often an afterthought, putting healthcare organizations at risk of data security and privacy issues, fines, damage to their reputations, with serious potential consequences for the patients. Electronic Health Record systems (EHRs) consist of clinical notes, patient listings, lab results, imaging results and screening tests. EHRs are growing in complexity over time and requiring increasing amounts of data storage. With the development of the IoT, the Cloud and Smart Cities frameworks, new privacy and security methods are being pursued to secure healthcare-based systems and platforms. Presenting a detailed framework as well as comparative case studies for security protection, data integrity, privacy preservation, scalability, and healthcare legislation, this edited volume covers state of the art research and addresses privacy and security methods and technologies for EHRs.