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All of us have lurking in our DNA a most remarkable gene. Its job
is straightforward - to protect us from cancer. This gene - known
simply as p53 - constantly scans our cells to ensure that they grow
and divide without mishap, as part of the routine maintenance of
our bodies. If a cell makes a mistake in copying its DNA as part of
its process of division, p53 stops it in its tracks, sending in the
repair team before allowing the cell to carry on dividing. If the
mistake is irreparable and the rogue cell threatens to grow out of
control (as happens in cancer), p53 commands the cell to commit
suicide. Cancer cannot develop unless p53 itself is damaged and
malfunctioning. Not surprisingly, p53 is the most studied gene in
history. This enormously important gene has teased the minds of
some of the most colourful and ambitious scientists around the
world. These characters populate Sue Armstrong's book p53: The Gene
that Cracked the Cancer Code, the story of medical science's
mission to unravel the mysteries of this gene and to get to the
heart of what happens in our cells when they turn cancerous. p53:
The Gene that Cracked the Cancer Code reveals the tale of the
search for this gene, as well as the excitement of the hunt for new
cures - the hype, the lost opportunities, the blind alleys and the
thrilling breakthroughs.As the long-anticipated revolution in
cancer treatment tailored to each individual patient's symptoms
starts to take off at last, p53 is still at the forefront of the
game. This is a timely tale of scientific discovery and advances in
our understanding of a disease that still affects more than one in
three of us at some point in our lives.
As featured on BBC Radio 4's Start the Week 'A rich, timely study
for the era of "global ageing"' Nature The ageing of the world
population is one of the most important issues facing humanity in
the 21st century - up there with climate change in its potential
global impact. Sometime before 2020, the number of people over 65
worldwide will, for the first time, be greater than the number of
0-4 year olds, and it will keep on rising. The strains this is
causing on society are already evident as health and social
services everywhere struggle to cope with the care needs of the
elderly. But why and how do we age? Scientists have been asking
this question for centuries, yet there is still no agreement. There
are a myriad competing theories, from the idea that our bodies
simply wear out with the rough and tumble of living, like well-worn
shoes or a rusting car, to the belief that ageing and death are
genetically programmed and controlled. In Borrowed Time, Sue
Armstrong tells the story of science's quest to understand ageing
and to prevent or delay the crippling conditions so often
associated with old age. She focusses inward - on what is going on
in our bodies at the most basic level of the cells and genes as the
years pass - to look for answers to why and how our skin wrinkles
with age, our wounds take much longer to heal than they did when we
were kids, and why words escape us at crucial moments in
conversation.This book explores these questions and many others
through interviews with key scientists in the field of gerontology
and with people who have interesting and important stories to tell
about their personal experiences of ageing.
All of us have lurking in our DNA a most remarkable gene, which has
a crucial job - it protects us from cancer. Known simply as p53,
this gene constantly scans our cells to ensure that they grow and
divide without mishap, as part of the routine maintenance of our
bodies. If a cell makes a mistake in copying its DNA during the
process of division, p53 stops it in its tracks, summoning a repair
team before allowing the cell to carry on dividing. If the mistake
is irreparable and the rogue cell threatens to grow out of control,
p53 commands the cell to commit suicide. Cancer cannot develop
unless p53 itself is damaged or prevented from functioning
normally. Perhaps unsurprisingly, p53 is the most studied single
gene in history. This book tells the story of medical science's
mission to unravel the mysteries of this crucial gene, and to get
to the heart of what happens in our cells when they turn cancerous.
Through the personal accounts of key researchers, p53: The Gene
that Cracked the Cancer Code reveals the fascination of the quest
for scientific understanding, as well as the huge excitement of the
chase for new cures - the hype, the enthusiasm, the lost
opportunities, the blind alleys, and the thrilling breakthroughs.
And as the long-anticipated revolution in cancer treatment tailored
to each individual patient's symptoms begins to take off at last,
p53 remains at the cutting edge. This timely tale of scientific
discovery highlights the tremendous recent advances made in our
understanding of cancer, a disease that affects more than one in
three of us at some point in our lives.
Based on a programme developed by a leading team of dermatologists and psychologists at the Chelsea and Westminster Hospital, The Eczema Solution is the essential book for eczema sufferers. Each chapter represents an 'appointment' and takes you through the stages of first learning about eczema, then controlling it and finally banishing it for good. The key to the programme is to stop scratching. Research at the Chelsea and Westminster has shown that no amount of emollient or steroids will work if scratching continues. This is much easier said than done which is why The Eczema Solution provides foolproof techniques to break, and then replace, the scratching habit. The Eczema Solution offers a unique approach to tackling eczema including:--Awareness of when and how you scratch --Using treatments effectively and for as little time as possible--Boosting your emotional well being by being in control of your eczemaWith a troubleshooting and question and answer section to deal with common problems, The Eczema Solution is your route to a life without eczema.
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Discovery Miles 3 400
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