Modern Japan's repressed anxieties, fears and hopes come to the surface in the fantastic. A close analysis of fantasy fiction, film and comics reveals the ambivalence felt by many Japanese towards the success story of the nation in the twentieth century.
The Fantastic in Modern Japanese Literature explores the dark side to Japanese literature and Japanese society. It takes in the nightmarish future depicted in the animated film masterpiece, Akira, and the pastoral dream worlds created by Japan's Nobel Prize winning author Oe Kenzaburo. A wide range of fantasists, many discussed here in English for the first time, form the basis for a ground-breaking analysis of utopias, dystopias, the disturbing relationship between women, sexuality and modernity, and the role of the alien in the fantastic.

Modern Japan's repressed anxieties, fears and hopes come to the surface in the fantastic. A close analysis of fantasy fiction, film and comic strips reveals the ambivalence felt by many Japanese towards the success story of the nation in the twentieth century
The Fantastic in Modern Japanese Literature explores the dark side to Japanese literature and Japanese society. It takes in the nightmarish future depicted in the animated film masterpiece, Akira, and the pastoral dream worlds created by Japan's Nobel Prize winning author Oe Kenzaburo. A wide range of fantasists, many discussed here in English for the first time, form the basis for a ground-breaking analysis of utopias, dystopias, the disturbing relationship between women, sexuality and modernity, and the role of the alien in the fantastic.

Transporters are proteins which span the plasma membrane and regulate the traffic of small molecules in and out of the cell. Transporters play a particularly important role in chemical signalling between neurons in the CNS, where they act to control the concentration of neurotransmitters in the synapse. The majority of transporters which are actively being pursued as targets for drug discovery are CNS located and this reflects the history of the field which began with the tricyclic antidepressants (TCAs) over half a century ago. The use of transporter inhibition to regulate the synaptic concentrations of key neurotransmitters is an established approach in the discovery of psychiatric medications. This volume reviews advances in the field of transporters as targets for drug discovery in the last 10 years. The volume will be of interest to scientists engaged in drug research in the pharmaceutical industry, biotech and academia. Following an overview chapter, seven chapters written by leading experts in their area reflect a range of topics pertinent to the transporter field. General topics include recent advances in the structural biology of transporters and its impact on potential structure based drug design and the design of ligands for Positron Emission Tomography and the importance of molecular imaging in understanding early clinical data. Medicinal chemistry approaches are described outlining the discovery of selective serotonin, noradrenaline and dopamine reuptake inhibitors, current efforts towards the discovery of mixed re-uptake inhibitors with varied flavours of monoamine inhibition, advances in the development of inhibitors for the glycine transporter and the discovery of subtype selective EAAT inhibitors. In addition to being an interesting read, the reader will receive a critical overview of progress made in this rapidly developing field."

Transporters are proteins that span the plasma membrane and regulate the traf?c of small molecules in and out of the cell. They play a particularly important role in chemical signalling between neurons in the CNS, where they act to control the concentration of neurotransmitters in the synapse. In most systems the termination of chemical transmission is achieved by rapid uptake of the transmitter molecule from the synapse by transporters located on the synaptic terminal or surrounding glial cells. Another key role for transporters is in excluding undesirable xenobiotics from the cell, whilst allowing key molecules required for the cell life cycle to enter. It is incre- ingly recognised that these ef?ux or uptake transporters respectively, play an important role in the disposition of many marketed drugs, and whilst the ?eld of drug transport is yet to attain the level of maturity of drug metabolism, itiscertaintobeofincreasingimportance infuturedrugdisc- ery programmes. 2 Transporter Classification Transporters can be classed into two main families; the ATP binding c- sette (ABC) family, and the solute carrier (SLC) family. The SLC family is a very broad categorisation which encompasses, amongst others, three - portant families of transporters for organic molecules; the major facilitator superfamily (MFS) and two neurotransmitter transporter families, the neu- transmitter; sodium symporter (NSS, or SLC6) and the dicarboxylate/amino + + acid: cation (Na or H ) symporter (DAACS, or SLC1) famil

The story of filmmaker Hayao Miyazaki's life and work, including his significant impact on Japan and the world-"an essential work in anime scholarship." (Angelica Frey, Hyperallergic) A thirtieth-century toxic jungle, a bathhouse for tired gods, a red-haired fish girl, and a furry woodland spirit-what do these have in common? They all spring from the mind of Hayao Miyazaki, one of the greatest living animators, known worldwide for films such as My Neighbor Totoro, Princess Mononoke, Spirited Away, Howl's Moving Castle, and The Wind Rises. Japanese culture and animation scholar Susan Napier explores the life and art of this extraordinary Japanese filmmaker to provide a definitive account of his oeuvre. Napier insightfully illuminates the multiple themes crisscrossing his work, from empowered women to environmental nightmares to utopian dreams, creating an unforgettable portrait of a man whose art challenged Hollywood dominance and ushered in a new chapter of global popular culture.