From a childhood exposed to public health to his career as a doctor, the author follows a wandering path from internal medicine to infectious diseases, preventive medicine, outpatient clinics, and public health. Along the way he encounters patients with rare or unusual twists, earns scars from the War against Poverty, and has memorable experiences with medical students. In addition, he helped establish the Emory School of Public Health at Emory University, where he was the Chairman of Preventive Medicine until his retirement in 1990. Few, if any of these experiences were planned. He found that many were accidental, some were unwelcome, but all were rewarding in the end.

In "What's Up, Doc?," Dr. Sellers shares the ups and downs of his forty-four year career in medicine.