Modeling of Oxygen Transport to Skeletal Muscle: Blood Flow Distribution, Shunt, and Diffusion.- The Haldane Effect of Rabbit Blood Under Different Acid-Base Conditions.- Interaction of Blood Flow, Diffusive Transport and Cell Metabolism in Isovolemic Anemia.- The Role of Wall Shear Stress in Microvascular Network Adaptation.- Changes in Tissue Histology Associated with Adaptation and Acclimation to Hypoxia.- Transcutaneous Measurements of Skin O2 Supply and Blood Gases.- Relating Measuring Signals from PO2 Electrodes to Tissue PO2: A Theoretical Study.- A New Catheter for Quasi-Continuous Measurement of Arterial Partial Oxygen Pressure.- Continuous Intra-Arterial PO2 Monitoring During Thoracic Surgery.- Construction, Calibration and Evaluation of PO2 Electrodes for Chronical Implantation in the Rabbit Brain Cortex.- Photothrombosis in Rabbit Brain Cortex: Follow Up by Continuous pO2 Measurement.- Intravitreal and Intraretinal Oxygen Tension in the Rat Eye.- Brain Oxygenation State: Preparation of Isolated Perfused Rat Brain and Near-Infrared Spectrophotometry.- The Simultaneous Measurement of the Redox State of Cytochrome Oxidase in Heart and Brain of Rat In Vivo by NIR.- Picosecond Time of Flight Measurement of Living Tissue: Time Resolved Beer-Lambert Law.- Cerebral Oxygenation State in Chemically-Induced Seizures in the Rat: Study by Near Infrared Spectrophotometry.- Experimentally Measured Optical Pathlengths for the Adult Head, Calf and Forearm and the Head of the Newborn Infant as a Function of Inter Optode Spacing.- Near-Infrared Imaging in vivo (I): Image Restoration Technique Applicable to the NIR Projection Images.- Muscle Oxygenation by Fast Near Infrared Spectrophotometry (NIRS) in Ischemic Forearm.- Near-Infrared Imaging in vivo (II): 2-Dimensional Visualization of Tissue Oxygenation State.- Monitoring of the Oxygen Pressure in the Blood of Live Animals Using the Oxygen Dependent Quenching of Phosphorescence.- Nuclear Magnetic Resonance Spectroscopy and the Study of Tissue Oxygen Metabolism: A Review.- On-Line Oxygen Uptake Measurement (VO2): A Computer Feed-Back Controlled Rebreathing Circuit for Long Term Oxygen Uptake Registration.- Oxygen Delivery (DEL O2) Dependent and Independent Oxygen Consumption (VO2).- Microtopographic Analysis of Oxidative Stress in Organ Microcirculatory Units.- Cytochrome P-450 Under Conditions of Oxidative Stress: Role of Antioxidant Recycling in the Protection Mechanisms.- Ischemia-Reperfusion Injury and Free Radical Involvement in Gastric Mucosal Disorders.- Influence of Anti-Inflammatory Drugs and Free Radical Scavengers on Intestinal Ischemia Induced Oxidative Tissue Damage.- Influence of Free Radical Scavengers on Myeloperoxidase Activity and Lipid Peroxidation in Acute Skin Grafts.- Morphometric Methods for the Evaluation of Capillary Grouping Patterns in Rat Heart.- Estimation of the Oxygen Gradient Across Phospholipid Bilayers of Mitochondria from Reperfused Rabbit Hearts after Ischemia.- The Oxygen Dependence of Mitochondrial Oxidative Phosphorylation and Its Role in Regulation of Coronary Blood Flow.- Oxygen Penetration in and Release from Lung Surfactant.- Improvement of Pulmonary Gas Exchange After Surfactant Replacement in Rats With Pneumocystis Carinii Pneumonia.- Attenuation of Hypoxic Pulmonary Vasoconstriction in Acute Oleic Acid Lung Injury: Significance of Vasodilator Prostanoids.- 99mTc-DTPA Clearance: A Sensitive Method for Early Detection of An Impending Disturbance in Gas Exchange.- Acute Respiratory Failure During Pneumonia Induced by Sendai Virus.- Estimation of Respiratory Mechanics in Dogs with Acute Lung Injury.- Effect of Hyperventilation on Oxygenation of the Brain Cortex of Neonates.- Hypoxia and the "Reaction Theory" of Central Respiratory Chemosensitivity.- Oxygenation of Mammary Tumors: From Isotransplanted Rodent Tumors to Primary Malignancies in Patients.- Measurements of Tumor Blood Flow Using Intraperitoneal Deuterium and 2H-NMR Spectroscopy....

The International Societyon Oxygen Transport to Tissue (ISOTT) was founded in 1973 "to facilitate the exchange of scientific information among those interested in any aspect of the transport and/or utilization of oxygen in tissues." Its members span virtually all disciplines, extending from various branches of clinical medicine such as anesthesiology, ophthalmology and surgery through the basic medical sciences of physiology and biochemistry to most branches ofthe physical sciences and engineering. The eighteenth annual meeting of ISOTT was held in 1990 for four days, from July 19 to 22, in the Sheraton Hotel in Townsville, Queensland, Australia. The usual ISOTT format, which was originated in 1985 by Dr. Ian Longmuir, was continued. Almost all presentations were posters with an accompanying, scheduled, brief, slide presentation and discussion. All posters remained in place for the entire four days of the meeting. There were no simultaneous sessions. Essentially all aspects of physiological transport were covered at this meeting with possibly somewhat more emphasis on methods and instrumentation. The editors gratefully acknowledge the photographic skills of Dr. Jens Hoper who took the group picture during the outing to Magnetic Island on July 21. We are also most grateful to Dr. Rod D. Braun of Evanston for his invaluable editorial assistance. This volume is the thirteenth in the Plenum series Oxygen Transport to Tissue.

The Ottawa '88 meeting of the International Society for Oxygen Transport to Tissue attracted a record number of participants and presentations. We were able to avoid simultaneous sessions and still keep the scientific program to four days by using poster sessions followed by plenary debate on each poster. To paraphrase the British physicist David Bohm, we tried to avoid an ordinary discussion, in which people usually stick to a relatively fixed position and try to convince others to change. This situation does not give rise to anything creative. So, we attempted instead to establish a true dialogue in which a person may prefer and support a certain point of view, but does not hold it nonnegotiab1y. He or she is ready to listen to others with sufficient sympathy, and is also ready to change his or her own view if there is a good reason to do so. Our Society is in its "teen" years, and there are even some arguments about its exact age. Many newer members have raised questions concerning the history of the Society. For this reason, I have asked one of the "founding fathers," D. Bruley, to prepare a brief account of the birth and early history of the Society which appears on the following page.