|
Showing 1 - 5 of
5 matches in All Departments
The aim of this book is to present a range of analytical methods
that can be used in formulation design and development and focus on
how these systems can be applied to understand formulation
components and the dosage form these build. To effectively design
and exploit drug delivery systems, the underlying characteristic of
a dosage form must be understood--from the characteristics of the
individual formulation components, to how they act and interact
within the formulation, and finally, to how this formulation
responds in different biological environments. To achieve this,
there is a wide range of analytical techniques that can be adopted
to understand and elucidate the mechanics of drug delivery and drug
formulation. Such methods include e.g. spectroscopic analysis,
diffractometric analysis, thermal investigations, surface
analytical techniques, particle size analysis, rheological
techniques, methods to characterize drug stability and release, and
biological analysis in appropriate cell and animal models. Whilst
each of these methods can encompass a full research area in their
own right, formulation scientists must be able to effectively apply
these methods to the delivery system they are considering. The
information in this book is designed to support researchers in
their ability to fully characterize and analyze a range of delivery
systems, using an appropriate selection of analytical techniques.
Due to its consideration of regulatory approval, this book will
also be suitable for industrial researchers both at early stage up
to pre-clinical research.
The aim of this book is to present a range of analytical methods
that can be used in formulation design and development and focus on
how these systems can be applied to understand formulation
components and the dosage form these build. To effectively design
and exploit drug delivery systems, the underlying characteristic of
a dosage form must be understood--from the characteristics of the
individual formulation components, to how they act and interact
within the formulation, and finally, to how this formulation
responds in different biological environments. To achieve this,
there is a wide range of analytical techniques that can be adopted
to understand and elucidate the mechanics of drug delivery and drug
formulation. Such methods include e.g. spectroscopic analysis,
diffractometric analysis, thermal investigations, surface
analytical techniques, particle size analysis, rheological
techniques, methods to characterize drug stability and release, and
biological analysis in appropriate cell and animal models. Whilst
each of these methods can encompass a full research area in their
own right, formulation scientists must be able to effectively apply
these methods to the delivery system they are considering. The
information in this book is designed to support researchers in
their ability to fully characterize and analyze a range of delivery
systems, using an appropriate selection of analytical techniques.
Due to its consideration of regulatory approval, this book will
also be suitable for industrial researchers both at early stage up
to pre-clinical research.
This comprehensive volume compiles the concepts essential for the
understanding of the pharmaceutical science and technology
associated with the delivery of subunit vaccines. Twenty-one
chapters are divided into four main parts: (I) Background; (2)
Delivery Systems for Subunit Vaccines; (3) Delivery Routes, Devices
and Dosage Forms; and (4) Pharmaceutical Analysis and Quality
Control of Vaccines. Part one provide a basic background with
respect to immunology and general vaccine classification. In part
two, it presents representative types of vaccine delivery systems
individually with focus on the physicochemical properties of the
systems and their significance for the immune response they
stimulate. These delivery systems include aluminum adjuvants,
emulsions, liposomes, bilosomes, cubosomes/hexosomes, ISCOMs,
virus-like particles, polymeric nano- and microparticles, gels,
implants and cell-based delivery systems. Following these chapters,
part three addresses the challenges associated with vaccine
delivery via specific routes of administration-in particular
subcutaneous, intramuscular, oral, nasal, pulmonary, transdermal
and vaginal administration. Furthermore, the specific
administration routes are discussed in combination with device
technologies relevant for the respective routes as well as dosage
forms appropriate for the device technology. Finally, the fourth
part concerns pharmaceutical analysis and quality control of
subunit vaccines.
A significant improvement in the safety of modern vaccines has been
the development of subunit vaccines, as these are composed of very
well-defined and highly pure components, often recombinant
proteins. However, since protein-based antigens in general are
weakly immunogenic by themselves, co-administration of adjuvants is
required to induce potent and persistent specific immune responses.
In recent years, there has been substantial progress in the
discovery of new efficient adjuvants for subunit vaccines that are
often classified into delivery systems and immunopotentiating
compounds that constitute pathogen-associated molecular patterns,
such as the toll-like receptor ligands. The combination of delivery
systems and immunopotentiators has appeared to represent
extraordinarily good adjuvants due to concomitant enhanced antigen
delivery and potent stimulation of innate immunity. Many of these
adjuvants are of a particulate nature and mimic the structure
and/or composition of microbes in a reductionist fashion. Examples
are liposomes, polymeric nanoparticles, emulsions and virus-like
particles. However, there are a substantial number of
pharmaceutical challenges associated with the subunit vaccine
development process due to the complex nature of the
antigen-adjuvant combinations. These challenges will be presented
and discussed in this book. The objective of the book is to compile
the concepts essential for the understanding of the pharmaceutical
science and technology associated with the delivery of subunit
vaccines. The books goal is to provide a comprehensive overview of
the scientific and regulatory challenges facing scientists who
research and develop subunit vaccines. The scope of the book is
wide. It is written in a manner that will enlighten newcomers to
the field (e.g., PhD students or experienced scientist switching
fields) yet provide an in-depth knowledge that would benefit a
skilled worker in the field. "
This "FASTtrack" book systematically reviews important concepts and
facts relating to the delivery and targeting of drugs. Relevant
examples of delivery systems are given throughout the book with a
focus on delivery systems that have actually reached clinical
reality.
|
You may like...
Loot
Nadine Gordimer
Paperback
(2)
R398
R330
Discovery Miles 3 300
|