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In the last quarter century, advances in mass spectrometry (MS)
have been at the forefront of efforts to map complex biological
systems including the human metabolome, proteome, and microbiome.
All of these developments have allowed MS to become a
well-established molecular level technology for microorganism
characterization. MS has demonstrated its considerable advantage as
a rapid, accurate, and cost-effective method for microorganism
identification, compared to conventional phenotypic techniques. In
the last several years, applications of MS for microorganism
characterization in research, clinical microbiology,
counter-bioterrorism, food safety, and environmental monitoring
have been documented in thousands of publications. Regulatory
bodies in Europe, the US, and elsewhere have approved MS-based
assays for infectious disease diagnostics. As of mid-2015, more
than 3300 commercial MS systems for microorganism identification
have been deployed worldwide in hospitals and clinical labs. While
previous work has covered broader approaches in using MS to
characterize microorganisms at the species level or above, this
book focuses on strain-level and subtyping applications. In twelve
individual chapters, innovators, leaders and practitioners in the
field from around the world have contributed to a comprehensive
overview of current and next-generation approaches for MS-based
microbial characterization at the subspecies and strain levels.
Chapters include up-to-date reference lists as well as web-links to
databases, recommended software, and other useful tools. The
emergence of new, antibiotic-resistant strains of human or animal
pathogens is of extraordinary concern not only to the scientific
and medical communities, but to the general public as well.
Developments of novel MS-based assays for rapid identification of
strains of antibiotic-resistant microorganisms are reviewed in the
book as well. Microbiologists, bioanalytical scientists, infectious
disease specialists, clinical laboratory and public health
practitioners as well as researchers in universities, hospitals,
government labs, and the pharmaceutical and biotechnology
industries will find this book to be a timely and valuable
resource.
In the last quarter century, advances in mass spectrometry (MS)
have been at the forefront of efforts to map complex biological
systems including the human metabolome, proteome, and microbiome.
All of these developments have allowed MS to become a
well-established molecular level technology for microorganism
characterization. MS has demonstrated its considerable advantage as
a rapid, accurate, and cost-effective method for microorganism
identification, compared to conventional phenotypic techniques. In
the last several years, applications of MS for microorganism
characterization in research, clinical microbiology,
counter-bioterrorism, food safety, and environmental monitoring
have been documented in thousands of publications. Regulatory
bodies in Europe, the US, and elsewhere have approved MS-based
assays for infectious disease diagnostics. As of mid-2015, more
than 3300 commercial MS systems for microorganism identification
have been deployed worldwide in hospitals and clinical labs. While
previous work has covered broader approaches in using MS to
characterize microorganisms at the species level or above, this
book focuses on strain-level and subtyping applications. In twelve
individual chapters, innovators, leaders and practitioners in the
field from around the world have contributed to a comprehensive
overview of current and next-generation approaches for MS-based
microbial characterization at the subspecies and strain levels.
Chapters include up-to-date reference lists as well as web-links to
databases, recommended software, and other useful tools. The
emergence of new, antibiotic-resistant strains of human or animal
pathogens is of extraordinary concern not only to the scientific
and medical communities, but to the general public as well.
Developments of novel MS-based assays for rapid identification of
strains of antibiotic-resistant microorganisms are reviewed in the
book as well. Microbiologists, bioanalytical scientists, infectious
disease specialists, clinical laboratory and public health
practitioners as well as researchers in universities, hospitals,
government labs, and the pharmaceutical and biotechnology
industries will find this book to be a timely and valuable
resource.
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